Major depressive disorder

Publication Title: 
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence.

Author(s): 
Ravindran, Arun V.
Balneaves, Lynda G.
Faulkner, Guy
Ortiz, Abigail
McIntosh, Diane
Morehouse, Rachel L.
Ravindran, Lakshmi
Yatham, Lakshmi N.
Kennedy, Sidney H.
Lam, Raymond W.
MacQueen, Glenda M.
Milev, Roumen V.
Parikh, Sagar V.
CANMAT Depression Work Group
Publication Title: 
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence.

Author(s): 
Ravindran, Arun V.
Balneaves, Lynda G.
Faulkner, Guy
Ortiz, Abigail
McIntosh, Diane
Morehouse, Rachel L.
Ravindran, Lakshmi
Yatham, Lakshmi N.
Kennedy, Sidney H.
Lam, Raymond W.
MacQueen, Glenda M.
Milev, Roumen V.
Parikh, Sagar V.
CANMAT Depression Work Group
Publication Title: 
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) has revised its 2009 guidelines for the management of major depressive disorder (MDD) in adults by updating the evidence and recommendations. The target audiences for these 2016 guidelines are psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence.

Author(s): 
Parikh, Sagar V.
Quilty, Lena C.
Ravitz, Paula
Rosenbluth, Michael
Pavlova, Barbara
Grigoriadis, Sophie
Velyvis, Vytas
Kennedy, Sidney H.
Lam, Raymond W.
MacQueen, Glenda M.
Milev, Roumen V.
Ravindran, Arun V.
Uher, Rudolf
CANMAT Depression Work Group
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: To report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). DESIGN: Systematic review and meta-analysis. SETTINGS: Outpatient clinics. SUBJECTS: Adults, aged 18 years and older, with MDD receiving an initial treatment attempt with SGA. INTERVENTIONS: Any CAM or exercise intervention compared with an SGA.

Author(s): 
Asher, Gary N.
Gartlehner, Gerald
Gaynes, Bradley N.
Amick, Halle R.
Forneris, Catherine
Morgan, Laura C.
Coker-Schwimmer, Emmanuel
Boland, Erin
Lux, Linda J.
Gaylord, Susan
Bann, Carla
Pierl, Christiane Barbara
Lohr, Kathleen N.
Publication Title: 
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. METHODS: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence.

Author(s): 
Ravindran, Arun V.
Balneaves, Lynda G.
Faulkner, Guy
Ortiz, Abigail
McIntosh, Diane
Morehouse, Rachel L.
Ravindran, Lakshmi
Yatham, Lakshmi N.
Kennedy, Sidney H.
Lam, Raymond W.
MacQueen, Glenda M.
Milev, Roumen V.
Parikh, Sagar V.
CANMAT Depression Work Group
Publication Title: 
Restorative Neurology and Neuroscience

A vast number of imaging studies have demonstrated the impact of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) on emotion and memory-related networks in the context of Major Depressive Disorder (MDD). Underlying molecular mechanisms that affect the functionality of these networks have been examined in detail in animals and corroborate imaging findings.

Author(s): 
Kuhn, Manuel
Popovic, Ana
Pezawas, Lukas
Publication Title: 
Biological Psychiatry

BACKGROUND: Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined. METHODS: We performed DNA modification analysis in white blood cells from monozygotic twins discordant for MDD, in brain prefrontal cortex, and germline (sperm) samples from affected individuals and control subjects (total N = 304) using 8.1K CpG island microarrays and fine mapping.

Author(s): 
Oh, Gabriel
Wang, Sun-Chong
Pal, Mrinal
Chen, Zheng Fei
Khare, Tarang
Tochigi, Mamoru
Ng, Catherine
Yang, Yeqing A.
Kwan, Andrew
Kaminsky, Zachary A.
Mill, Jonathan
Gunasinghe, Cerisse
Tackett, Jennifer L.
Gottesman, Irving I.
Willemsen, Gonneke
de Geus, Eco J. C.
Vink, Jacqueline M.
Slagboom, P. Eline
Wray, Naomi R.
Heath, Andrew C.
Montgomery, Grant W.
Turecki, Gustavo
Martin, Nicholas G.
Boomsma, Dorret I.
McGuffin, Peter
Kustra, Rafal
Petronis, Art
Publication Title: 
Journal of Affective Disorders

Considerable evidence suggests a crucial role for the epigenetic regulation of brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BDNF DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BDNF promoter region and WM integrity in MDD.

Author(s): 
Choi, Sunyoung
Han, Kyu-Man
Won, Eunsoo
Yoon, Bong-June
Lee, Min-Soo
Ham, Byung-Joo
Publication Title: 
Epigenetics

Aberrant DNA methylation in the blood of patients with major depressive disorder (MDD) has been reported in several previous studies. However, no comprehensive studies using medication-free subjects with MDD have been conducted. Furthermore, the majority of these previous studies has been limited to the analysis of the CpG sites in CpG islands (CGIs) in the gene promoter regions. The main aim of the present study is to identify DNA methylation markers that distinguish patients with MDD from non-psychiatric controls.

Author(s): 
Numata, Shusuke
Ishii, Kazuo
Tajima, Atsushi
Iga, Jun-ichi
Kinoshita, Makoto
Watanabe, Shinya
Umehara, Hidehiro
Fuchikami, Manabu
Okada, Satoshi
Boku, Shuken
Hishimoto, Akitoyo
Shimodera, Shinji
Imoto, Issei
Morinobu, Shigeru
Ohmori, Tetsuro
Publication Title: 
International Journal of Epidemiology

BACKGROUND: Several broad lines of evidence support the involvement of epigenetic processes in neurodevelopment and psychiatric disorders. Epigenetic disruption also provides a potential mechanism to account for the numerous gene-environment interactions that have been reported in association with neuropsychiatric phenotypes. METHODS: A review of the literature was performed with keywords 'depression', 'depressive disorder' or 'antidepressants' and 'DNA methylation', or 'epigenetics' in humans.

Author(s): 
Januar, Vania
Saffery, Richard
Ryan, Joanne

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