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Publication Title: 
Journal of the American Geriatrics Society

Four families highly clustered for extreme longevity are described here, representing the first report of clustering for this phenotype. Families such as these may prove to be helpful in the further understanding of the genetic contribution to achieving exceptional longevity.

Author(s): 
Perls, T.
Shea-Drinkwater, M.
Bowen-Flynn, J.
Ridge, S. B.
Kang, S.
Joyce, E.
Daly, M.
Brewster, S. J.
Kunkel, L.
Puca, A. A.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wide scan for such predisposing loci was conducted by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity.

Author(s): 
Puca, A. A.
Daly, M. J.
Brewster, S. J.
Matise, T. C.
Barrett, J.
Shea-Drinkwater, M.
Kang, S.
Joyce, E.
Nicoli, J.
Benson, E.
Kunkel, L. M.
Perls, T.
Publication Title: 
Asia Pacific Journal of Clinical Nutrition

Okinawans, who have a different ethnicity and food cultural history to other Japanese nationals, and an exceptional longevity have been studied at home and as migrant groups in Hawaii and Brazil. Biomarkers for fish and soy intake and intervention studies indicate that these foods, along with seaweed and green vegetables are candidates for chronic non-communicable disease prevention.

Author(s): 
Yamori, Y.
Miura, A.
Taira, K.
Publication Title: 
Journal of the American Geriatrics Society

There is a substantial distinction to be made between the genetics of aging and the genetics of exceptional longevity. Twin studies suggest that the average set of genetic variations facilitates the average human's ability to live well into their octogenarian years. Other studies indicate that taking full advantage of this average set results in spending the majority of those years in good health. However, many people counteract such genetic endowment with poor health habits, resulting in a substantially lower average life expectancy and relatively more time spent in poor health.

Author(s): 
Perls, Thomas
Kunkel, Louis M.
Puca, Annibale A.
Publication Title: 
Journal of molecular neuroscience: MN

How we age as individuals is no doubt a complex interaction of genetic and environmental factors. Studies of certain populations with optimal environments and health-related behaviors, as well as twin studies, suggest that the average set of genetic variations should facilitate the average person's ability to live to around age 85. Average life expectancies are lower than this because we generally fight survival advantage with bad health habits that can lead to premature aging, chronic illness, and death at a significantly younger age.

Author(s): 
Perls, Thomas
Kunkel, Louis M.
Puca, Annibale A.
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVE: A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition. This communication describes the clinical characterization and comparison of the experimental groups, validation of the experimental method, and results for the Y chromosome. METHODS: The genome survey was conducted at 10 cM resolution for simple sequence tandem repeat polymorphisms (SSTRPs) that identify genes for successful aging by virtue of linkage disequilibrium.

Author(s): 
Zubenko, George S.
Stiffler, J. Scott
Hughes, Hugh B.
Fatigati, Mario J.
Zubenko, Wendy N.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Families of centenarians have high levels of plasma high-density lipoprotein (HDL) cholesterol, which may have neurological as well as cardiovascular protective effects during aging. Because plasma HDL level declines progressively with aging, we examined whether centenarians with higher plasma HDL levels have better cognitive function.

Author(s): 
Atzmon, Gil
Gabriely, Ilan
Greiner, William
Davidson, Deborah
Schechter, Clyde
Barzilai, Nir
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: The compression of morbidity hypothesis predicts that, in order to achieve their extreme old age, centenarians markedly delay or even escape diseases that would otherwise be lethal at younger ages. Phenotypic studies have not adequately characterized the prevalence and timing of age-related illnesses among those who achieve exceptional old age. Thus, we conducted a retrospective cohort study of centenarians to explore the timing of such diseases among centenarians. METHODS: Health history questionnaires were completed by 424 centenarians (aged 97-119 years) or their proxies.

Author(s): 
Evert, Jessica
Lawler, Elizabeth
Bogan, Hazel
Perls, Thomas
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: A significant component of the ability to survive to exceptional old age may be familial. This study assessed the prevalence of age-related diseases in the offspring of centenarians. METHODS: The health histories of centenarian offspring (n=177) and controls (n=166) were assessed from 1997-2000 using a cross-sectional study design. The offspring of 192 centenarian subjects enrolled in the nationwide New England Centenarian Study were recruited and enrolled.

Author(s): 
Terry, Dellara F.
Wilcox, Marsha
McCormick, Maegan A.
Lawler, Elizabeth
Perls, Thomas T.
Publication Title: 
Experimental Gerontology

Centenarians exist at the extreme of life expectancy and are rare. A number of pedigree and molecular genetic studies indicate that a significant component of exceptional longevity is genetically influenced. Furthermore, the recent discovery of a genetic locus on chromosome 4 indicates the powerful potential of studying centenarians for genetic factors that significantly modulate aging and susceptibility to age-related diseases. These studies include siblings and children of centenarians.

Author(s): 
Perls, Thomas
Terry, Dellara

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