Mali

Publication Title: 
Culture, Health & Sexuality

This paper calls attention to an ideal of romantic love among young unmarried mothers in Mali. It demonstrates that romantic love constitutes a motivating force for the agency of young Malian mothers who invest themselves in hopes of romantic outcomes from their relationships. Like the majority of people in Mali, the young mothers in this study dedicated a considerable time each weekday to watching a Venezuelan soap opera, which could be regarded as offering a modern version of Romeo and Juliet. Yet, romance is not the only thing that matters in young mothers' ideals of love.

Author(s): 
S¯lbeck, Ditte Enemark
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

We conducted a randomized single-blinded trial comparing the efficacy and safety of artesunate (AS) + amodiaquine (AQ, 3 days) versus AS (3 days) + sulfadoxine-pyrimethamine (SP, single dose) versus AS monotherapy (5 days) in Southern Mali. Uncomplicated malaria cases were followed for 28 days. Molecular markers of drug resistance were determined. After identification of recrudescences by genotyping, both artemisinin-based combination therapies (ACTs) reached nearly 100% efficacy at Day 14 and Day 28 versus 98.3% and 96.5% for AS, respectively (P > 0.05).

Author(s): 
Djimde, Abdoulaye A.
Fofana, Bakary
Sagara, Issaka
Sidibe, Bakary
Toure, Sekou
Dembele, Demba
Dama, Souleymane
Ouologuem, Dinkorma
Dicko, Alassane
Doumbo, Ogobara K.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The choice of appropriate artemisin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate, and simplicity of administration). In this study, we tested the hypothesis that artesunate-mefloquine (Artequin) is as efficacious as artemether-lumefantrine (Coartem) in treatment of uncomplicated Plasmodium falciparum malaria. The study was carried out from August 2004 through February 2005 in Kambila, Mali. Subjects with weights >/= 10 kg and uncomplicated malaria were enrolled.

Author(s): 
Sagara, Issaka
Diallo, Abdoulbaki
Kone, Mamady
Coulibaly, Modibo
Diawara, Sory Ibrahima
Guindo, Ousmane
Maiga, Hamma
Niambele, Mohamed Balla
Sissoko, Mady
Dicko, Alassane
Djimde, Abdoulaye
Doumbo, Ogobara K.
Publication Title: 
Malaria Journal

BACKGROUND: Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS: Of 151 patients with presumed severe malaria, 23 children with blood glucose concentrations < 60 mg/dl (< 3.3 mmol/l) were assigned randomly to receive either intravenous 10% glucose (IVG; n = 9) or sublingual sugar (SLS; n = 14).

Author(s): 
Graz, Bertrand
Dicko, Moussa
Willcox, Merlin L.
Lambert, Bernard
Falquet, Jacques
Forster, Mathieu
Giani, Sergio
Diakite, Chiaka
Dembele, Eugène M.
Diallo, Drissa
Barennes, Hubert
Publication Title: 
Malaria Journal

BACKGROUND: Because of the emergence of chloroquine resistance in Mali, artemether-lumefantrine (AL) or artesunate-amodiaquine (AS+AQ) are recommended as first-line therapy for uncomplicated malaria, but have not been available in Mali until recently because of high costs. METHODS: From July 2005 to January 2006, a randomized open-label trial of three oral antimalarial combinations, namely AS+AQ, artesunate plus sulphadoxine-pyrimethamine (AS+SP), and amodiaquine plus sulphadoxine-pyrimethamine (AQ+SP), was conducted in Faladje, Mali.

Author(s): 
Kayentao, Kassoum
Maiga, Hamma
Newman, Robert D.
McMorrow, Meredith L.
Hoppe, Annett
Yattara, Oumar
Traoré, Hamidou
Kone, Younoussou
Guirou, Etienne A.
Saye, Renion
Traoré, Boubacar
Djimde, Abdoulaye
Doumbo, Ogobara K.
Publication Title: 
Malaria Journal

BACKGROUND: To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria. METHODS: During the malaria transmission seasons of 2002 and 2003, 455 children--between six and 59 months of age, with uncomplicated malaria in Kolle, Mali, were randomly assigned to one of three treatment arms. In vivo outcomes were assessed using WHO standard protocols.

Author(s): 
Tekete, Mamadou
Djimde, Abdoulaye A.
Beavogui, Abdoul H.
Maiga, Hamma
Sagara, Issaka
Fofana, Bakary
Ouologuem, Dinkorma
Dama, Souleymane
Kone, Aminatou
Dembele, Demba
Wele, Mamadou
Dicko, Alassane
Doumbo, Ogobara K.
Publication Title: 
Tropical medicine & international health: TM & IH

OBJECTIVE: To assess the efficacy of intermittent preventive treatment (IPT) against malaria in school-aged children. METHODS: This was an open randomized controlled trial of seasonal IPT among school children (IPTsc) aged 6-13 years in Kollé, Mali. The study began in September 2007 and completed follow-up in May 2008. Students were randomized to one of three study arms: Sulfadoxine-pyrimethamine plus artesunate (SP/AS), amodiaquine plus artesunate (AQ/AS) or vitamin C.

Author(s): 
Barger, Breanna
Maiga, Hamma
Traore, Oumar Bila
Tekete, Mamadou
Tembine, Intimbeye
Dara, Antoine
Traore, Zoumana Isaac
Gantt, Soren
Doumbo, Ogobara K.
Djimde, Abdoulaye A.
Publication Title: 
Malaria Journal

BACKGROUND: Artemisinin-based combination therapy (ACT) is currently the most effective medicine for the treatment of uncomplicated malaria. Artemisinin has previously been shown to increase the clearance of Plasmodium falciparum in malaria patients with haemoglobin E trait, but it did not increase parasite inhibition in an in vitro study using haemoglobin AS erythrocytes. The current study describes the efficacy of artemisinin derivatives on P.

Author(s): 
Kone, Abdoulaye K.
Sagara, Issaka
Thera, Mahamadou A.
Dicko, Alassane
Guindo, Aldiouma
Diakite, Seidina
Kurantsin-Mills, Joseph
Djimde, Abdoulaye
Walcourt, Asikiya
Doumbo, Ogabara
Publication Title: 
Malaria Journal

BACKGROUND: Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment. Yet, limited data is available on pharmacokinetic interactions between these drugs. METHODS: In a randomized controlled trial, children aged 6-59 months with uncomplicated falciparum malaria, received either one dose of sulphadoxine-pyrimethamine alone (SP), one dose of SP plus three daily doses of amodiaquine (SP+AQ) or one dose of SP plus 3 daily doses of artesunate (SP+AS).

Author(s): 
Tekete, Mamadou M.
Toure, Sekou
Fredericks, Alfia
Beavogui, Abdoul H.
Sangare, Cheick P. O.
Evans, Alicia
Smith, Peter
Maiga, Hamma
Traore, Zoumana I.
Doumbo, Ogobara K.
Barnes, Karen I.
Djimde, Abdoulaye A.
Publication Title: 
Health Policy and Planning

Malaria is the most common cause of morbidity and mortality in children under 5 in Mali. Health centres provide primary care, including malaria treatment, under a system of cost recovery. In 2005, Médecins sans Frontieres (MSF) started supporting health centres in Kangaba with the provision of rapid malaria diagnostic tests and artemisinin-based combination therapy. Initially MSF subsidized malaria tests and drugs to reduce the overall cost for patients. In a second phase, MSF abolished fees for all children under 5 irrespective of their illness and for pregnant women with fever.

Author(s): 
Ponsar, Frédérique
Van Herp, Michel
Zachariah, Rony
Gerard, Séco
Philips, Mit
Jouquet, Guillaume

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