Publication Title: 
Cell Biochemistry and Function

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers.

Mahesh, Ramalingam
Bhuvana, Shanmugham
Begum, Vava Mohaideen Hazeena
Publication Title: 
Journal of Ayurveda and Integrative Medicine

Triphala (TP) is composed of Emblica officinalis, Terminalia chebula, and Terminalia belerica. The present study was undertaken to evaluate its anticataract potential in vitro and in vivo in a selenite-induced experimental model of cataract. In vitro enucleated rat lenses were maintained in organ culture containing Dulbecco's Modified Eagles Medium alone or with the addition of 100?M selenite. These served as the normal and control groups, respectively. In the test group, the medium was supplemented with selenite and different concentrations of TP aqueous extract.

Gupta, Suresh Kumar
Kalaiselvan, V.
Srivastava, Sushma
Agrawal, Shyam S.
Saxena, Rohit
Publication Title: 
Biological & Pharmaceutical Bulletin

Terminalia chebula has been widely used in India as a folk medicine. This study investigated the in vivo anti-hyperglycemia and anti-diabetic complication effects of the EtOAc-soluble portion of ethanolic extract of T. chebula fruit (EETC) containing 29.4% chebulic acid. Rats were divided into non-diabetic, untreated diabetic and diabetic groups. Streptozotocin (40 mg/kg body weight (BW))-induced diabetic rats were orally administered the aminoguanidine (100 mg/kg BW), high dose (500 mg/kg BW; HEETC) and low dose (100 mg/kg BW; LEETC) for 13 weeks.

Kim, Ji-hoon
Hong, Chung-Oui
Koo, Yun-chang
Kim, Su-Jung
Lee, Kwang-Won
Publication Title: 
Molecules (Basel, Switzerland)

Terminalia chebula, native to Southeast Asia, is a popular medicinal plant in Ayurveda. It has been previously reported to have strong antioxidant and anti-inflammatory efficacy. In this study, we aimed to investigate if fruit extract from T. chebula might protect neuronal cells against ischemia and related diseases by reduction of oxidative damage and inflammation in rat pheochromocytoma cells (PC12) using in vitro oxygen-glucose deprivation followed by reoxygenation (OGD-R) ischemia and hydrogen peroxide (H2O2) induced cell death.

Gaire, Bhakta Prasad
Jamarkattel-Pandit, Nirmala
Lee, Donghun
Song, Jungbin
Kim, Ji Young
Park, Juyeon
Jung, Soyoung
Choi, Ho-Young
Kim, Hocheol
Publication Title: 
Pharmaceutical Biology

CONTEXT: Arthritis is inflammation of one or more joints. Terminalia chebula Retz. (Combretaceae) fruit is mentioned in Ayurveda as useful in treating arthritic disorders. OBJECTIVE: This work was undertaken to evaluate the anti-inflammatory, antioxidant, anti-lipid peroxidative and membrane-stabilizing effects of hydroalcoholic extract of Terminalia chebula fruits and also to establish a possible association between them. MATERIALS AND METHODS: In vivo anti-inflammatory activity of T. chebula fruit extract at different doses ranged from 50 to 500?mg/kg, p.o.

Bag, Anwesa
Kumar Bhattacharyya, Subir
Kumar Pal, Nishith
Ranjan Chattopadhyay, Rabi
Publication Title: 
Experimental Gerontology

Cellular senescence is a biological process associated with aging and longevity. Successful aging is believed to be related to the ability to cope with different environmental stresses. The objective of this study was to investigate if cellular senescence is associated with platelet membrane modifications on subjects of different age, in particular on monozygotic twins and if these changes might be affected by both genetic components and environmental factors. The work was performed on 81 monozygotic twin pairs of different age.

Nanetti, Laura
Laura, Nanetti
Moroni, Cinzia
Cinzia, Moroni
Vignini, Arianna
Arianna, Vignini
Vannini, Patrizia
Patrizia, Vannini
Franceschi, Claudio
Claudio, Franceschi
Mazzanti, Laura
Laura, Mazzanti
Publication Title: 
PloS One

BACKGROUND: The heavy metal lead has been shown to be associated with a genotoxic risk. Drosophila melanogaster is a model organism commonly utilized in genetic toxicology testing. The endosymbionts--Wolbachia are now very common in both wild populations and laboratory stocks of Drosophila. Wolbachia may induce resistance to pathogenic viruses, filarial nematodes and Plasmodium in fruit fly and mosquito hosts. However the effect of Wolbachia infection on the resistance of their hosts to heavy metal is unknown.

Wang, Ling
Zhou, Chun
He, Zhen
Wang, Zheng-Guang
Wang, Jia-Lin
Wang, Yu-Feng
Publication Title: 
Fish & Shellfish Immunology

Five feeding trials based on the isonitrogenous and isoenergetic experimental diets containing 34% protein, 6%, 8%, 10%, 12% or 14% lipid respectively in the circulating water culture system for both 30 and 60 days were conducted to investigate the effect of the dietary lipid level on the growth and immunity in white shirmp, Litopenaeus vannamei adults. The body weight and specific growth rate of white shrimp in different treatments indicated that shrimps fed the diet of 12% lipid level for 30d and 10% lipid level for 60d had the best developmental status.

Zhang, Sheng-peng
Li, Jin-feng
Wu, Xiao-chun
Zhong, Wei-jing
Xian, Jian-an
Liao, Shao-an
Miao, Yu-tao
Wang, An-li
Publication Title: 
Journal of Biological Regulators and Homeostatic Agents

There is increasing evidence that psychosocial stress can be viewed as a system-wide derangement of cellular homeostasis, with heightened oxidative stress and triggered proinflammatory mechanisms. The aim of this study is twofold: a) to replicate findings that psychological stress increases oxidative damage and b) to determine whether a fermented papaya preparation known to exert significant protective antioxidant properties could buffer such increases in nuclear DNA damage while also inducing epigenetic protective mechanisms.

Marotta, F.
Naito, Y.
Padrini, F.
Xuewei, X.
Jain, S.
Soresi, V.
Zhou, L.
Catanzaro, R.
Zhong, K.
Polimeni, A.
Chui, D. H.
Publication Title: 
BioFactors (Oxford, England)

Natural leaves and flowers containing numerous aroma chemicals are widely used in aromatherapy since ancient times. In addition to their pleasant smells, aroma chemicals might have some beneficial health effects. Aroma extracts, isolated from coffee beans, soybeans, and mung beans by steam distillation under mild conditions (55 degrees C and 85 mm Hg) were examined for their antioxidative activities. The inhibitory effect of these extracts toward hexanal/hexanoic acid conversion was measured in the testing solution over prolonged time periods.

Lee, K. G.
Mitchell, A.
Shibamoto, T.


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