Mammary Glands, Animal

Publication Title: 
Cell Cycle (Georgetown, Tex.)

Caloric restriction has been shown to increase lifespan in several organisms and to delay onset of age-related diseases. The transcriptional response to caloric restriction has been studied for mRNAs, while the microRNA signature following caloric restriction remains unexplored. Here, we characterize the microRNA expression in mouse breast tissue before and after caloric restriction, reporting several changes in the microRNA expression profile.

Author(s): 
ÿrom, Ulf Andersson
Lim, Meng K.
Savage, Jason E.
Jin, Lianjin
Saleh, Anthony D.
Lisanti, Michael P.
Simone, Nicole L.
Publication Title: 
Cell Cycle (Georgetown, Tex.)

Caloric restriction has been shown to increase lifespan in several organisms and to delay onset of age-related diseases. The transcriptional response to caloric restriction has been studied for mRNAs, while the microRNA signature following caloric restriction remains unexplored. Here, we characterize the microRNA expression in mouse breast tissue before and after caloric restriction, reporting several changes in the microRNA expression profile.

Author(s): 
ÿrom, Ulf Andersson
Lim, Meng K.
Savage, Jason E.
Jin, Lianjin
Saleh, Anthony D.
Lisanti, Michael P.
Simone, Nicole L.
Publication Title: 
Iranian Journal of Allergy, Asthma, and Immunology

Recent studies have indicated the profound anti-tumor activity of artemisinin's compounds, among which; arteether is an oil-soluble derivative of artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. An experiment was carried out on tumor-bearing Balb/c mice to estimate the effects of Arteether on tumor growth and antitumor immune responses. Briefly, 6mg/kg/day of Arteether and diluents were administered to two groups of mice. Tumor sizes were measured using digital verniercallipers.

Author(s): 
Azimi Mohamadabadi, Maryam
Hassan, Zuhair Muhammad
Zavaran Hosseini, Ahmad
Noori, Shekoofe
Mahdavi, Mehdi
Maroufizadeh, Saman
Maroof, Hamidreza
Publication Title: 
Cell

Although expression of the Fos family of transcription factors is induced by environmental stimuli that trigger adaptive neuronal response, evidence that Fos family members mediate these responses is lacking. To address this issue, mice were generated with an inactivating mutation in the fosB gene. fosB mutant mice are profoundly deficient in their ability to nurture young animals but are normal with respect to other cognitive and sensory functions. The nurturing defect is likely due to the absence of FosB in the preoptic area, a region of the hypothalamus that is critical for nurturing.

Author(s): 
Brown, J. R.
Ye, H.
Bronson, R. T.
Dikkes, P.
Greenberg, M. E.
Publication Title: 
The Journal of Nutrition

Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones was administered by gavage [250, 500 and 750 mg/(kg x d)] to virgin, ovariectomized 50-d-old Sprague-Dawley rats, for 21 d in the presence and absence of 17beta-estradiol [50 microg/(kg x d)]. Estrogenic effects included an increase in uterine weight, vaginal cell cornification and mammary gland duct branching.

Author(s): 
Burdette, Joanna E.
Liu, Jianghua
Lantvit, Dan
Lim, Eula
Booth, Nancy
Bhat, Krishna P. L.
Hedayat, Samad
van Breemen, Richard B.
Constantinou, Andreas I.
Pezzuto, John M.
Farnsworth, Norman R.
Bolton, Judy L.
Publication Title: 
Anticancer Research

Bamboo grass leaves of different Sasa species have been widely used in food and medicine in Eastern Asia for hundreds of years. Of special interest are Kumazasa (Sasa senanensis rehder) leaves used to prepare an alkaline extract known as Sasa Health. This extract was reported to inhibit both the development and growth of mammary tumors in a mammary tumor strain of virgin SHN mice (1). We found that Sasa Health exerts a significant protective effect on spontaneous mammary tumorigenesis in another mouse model of human breast cancer, the transgenic FVB-Her2/NeuN mouse model.

Author(s): 
Ren, Mingqiang
Reilly, R. Todd
Sacchi, Nicoletta
Publication Title: 
Biology of Reproduction

Soy isoflavonoids have well-established estrogenic properties in cell culture and rodent models, raising concerns that high isoflavonoid intake may promote development of uterine and breast cancers. To address this concern we evaluated the effects of high-dose isoflavonoid supplements on reproductive tissues in a postmenopausal primate model.

Author(s): 
Wood, Charles E.
Appt, Susan E.
Clarkson, Thomas B.
Franke, Adrian A.
Lees, Cynthia J.
Doerge, Daniel R.
Cline, J. Mark
Publication Title: 
Veterinary Pathology

Macaques provide an important animal model for the study of hormonal agents and their effects on risk biomarkers for breast cancer. A common criticism of this model is that spontaneous breast cancer has rarely been described in these animals. In this report, we characterize 35 mammary gland lesions ranging from ductal hyperplasia to carcinoma in situ and invasive ductal carcinoma in cynomolgus and rhesus macaques. Based on a retrospective analysis, we estimated the lifetime incidence of mammary gland neoplasia in aged female macaques to be about 6%.

Author(s): 
Wood, C. E.
Usborne, A. L.
Starost, M. F.
Tarara, R. P.
Hill, L. R.
Wilkinson, L. M.
Geisinger, K. R.
Feiste, E. A.
Cline, J. M.
Publication Title: 
Carcinogenesis

Endogenous estrogens are important determinants of breast cancer risk in postmenopausal women. In this study we evaluated the effects of dietary soy isoflavonoids on endogenous estrogen metabolism in a postmenopausal primate model.

Author(s): 
Wood, Charles E.
Register, Thomas C.
Cline, J. Mark
Publication Title: 
Toxicologic Pathology

Ductal morphogenesis of the mammary gland occurs largely in the early pubertal period under the influence of ovarian sex hormones. In this study we characterized developing ductal structures in breast tissue of 14 female prepubertal or early pubertal rhesus monkeys (average age, 2.6 +/- 0.1 years). Serum estradiol concentrations ranged from < 5.0 to 61.2 pg/ml, while progesterone concentrations were low in all animals (< 0.6 ng/ml). No corpora lutea were seen on ovarian histology.

Author(s): 
Wood, Charles E.
Hester, Joy M.
Cline, J. Mark

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