Mammary Neoplasms, Animal

Publication Title: 
Journal of Ethnopharmacology

A 70% methanol extract of Terminalia chebula fruit, was studied for its effects on growth in several malignant cell lines including a human (MCF-7) and mouse (S115) breast cancer cell line, a human osteosarcoma cell line (HOS-1), a human prostate cancer cell line (PC-3) and a non-tumorigenic, immortalized human prostate cell line (PNT1A) using assays for proliferation ([(3)H]-thymidine incorporation and coulter counting), cell viability (ATP determination) and cell death (flow cytometry and Hoechst DNA staining).

Author(s): 
Saleem, Ammar
Husheem, Michael
Härkönen, Pirkko
Pihlaja, Kalevi
Publication Title: 
Oncology Reports

Silent information regulator 2 (SIR2) is a highly conserved protein, the mammalian orthologue of which, SIRT1, exhibits histone deacetylase activity. SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration. However, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors suppress the growth of tumor cells. The relationship between SIRT1 and metastasis remains to be clarified.

Author(s): 
Suzuki, Kensuke
Hayashi, Ryuji
Ichikawa, Tomomi
Imanishi, Shingo
Yamada, Toru
Inomata, Minehiko
Miwa, Toshiro
Matsui, Shoko
Usui, Isao
Urakaze, Masaharu
Matsuya, Yuji
Ogawa, Hirofumi
Sakurai, Hiroaki
Saiki, Ikuo
Tobe, Kazuyuki
Publication Title: 
BMC medicine

BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers.

Author(s): 
Shibata, Masa-Aki
Iinuma, Munekazu
Morimoto, Junji
Kurose, Hitomi
Akamatsu, Kanako
Okuno, Yasushi
Akao, Yukihiro
Otsuki, Yoshinori
Publication Title: 
BMC medicine

BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers.

Author(s): 
Shibata, Masa-Aki
Iinuma, Munekazu
Morimoto, Junji
Kurose, Hitomi
Akamatsu, Kanako
Okuno, Yasushi
Akao, Yukihiro
Otsuki, Yoshinori
Publication Title: 
Biology of Reproduction

Soy isoflavonoids have well-established estrogenic properties in cell culture and rodent models, raising concerns that high isoflavonoid intake may promote development of uterine and breast cancers. To address this concern we evaluated the effects of high-dose isoflavonoid supplements on reproductive tissues in a postmenopausal primate model.

Author(s): 
Wood, Charles E.
Appt, Susan E.
Clarkson, Thomas B.
Franke, Adrian A.
Lees, Cynthia J.
Doerge, Daniel R.
Cline, J. Mark
Publication Title: 
Veterinary Pathology

Macaques provide an important animal model for the study of hormonal agents and their effects on risk biomarkers for breast cancer. A common criticism of this model is that spontaneous breast cancer has rarely been described in these animals. In this report, we characterize 35 mammary gland lesions ranging from ductal hyperplasia to carcinoma in situ and invasive ductal carcinoma in cynomolgus and rhesus macaques. Based on a retrospective analysis, we estimated the lifetime incidence of mammary gland neoplasia in aged female macaques to be about 6%.

Author(s): 
Wood, C. E.
Usborne, A. L.
Starost, M. F.
Tarara, R. P.
Hill, L. R.
Wilkinson, L. M.
Geisinger, K. R.
Feiste, E. A.
Cline, J. M.
Publication Title: 
Oncogene

A micro-RNA, miR-155, is overexpressed in many types of cancer cells, including breast cancer, and its role(s) in tumor metastasis has been studied on a very limited basis. Tumor metastasis is a multi-step process with the last step in the process being formation of macroscopic tumor in organs distant from the primary tumor site. This step is the least studied.

Author(s): 
Xiang, X.
Zhuang, X.
Ju, S.
Zhang, S.
Jiang, H.
Mu, J.
Zhang, L.
Miller, D.
Grizzle, W.
Zhang, H.-G.
Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

4-Vinylcyclohexene diepoxide (VCD), an occupational chemical that targets ovarian follicles and accelerates ovarian failure in rodents, was used to test the effect of early-onset reproductive senescence on mammary fibroadenoma formation. One-month female Sprague Dawley rats were dosed with VCD (80 mg/kg or 160 mg/kg) and monitored for 22 months for persistent estrus and tumor development. Only high-dose VCD treatment accelerated the onset of persistent estrus relative to controls. However, both doses of VCD accelerated mammary tumor onset by 5 months, increasing incidence to 84% (vs.

Author(s): 
Wright, Laura E.
Frye, Jennifer B.
Lukefahr, Ashley L.
Marion, Samuel L.
Hoyer, Patricia B.
Besselsen, David G.
Funk, Janet L.
Publication Title: 
Endocrine-Related Cancer

Obesity is an established risk and progression factor for postmenopausal breast cancer. Interventions to decrease caloric intake and/or increase energy expenditure beneficially impact tumor progression in normoweight humans and animal models. However, despite the increasingly high global prevalence of obesity, the effects and underlying mechanisms of these energy balance modulating interventions are poorly characterized in obese individuals.

Author(s): 
Nogueira, Leticia M.
Dunlap, Sarah M.
Ford, Nikki A.
Hursting, Stephen D.
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