Mammary Tumor Virus, Mouse

Publication Title: 
Journal of the National Cancer Institute

BACKGROUND: Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS: Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA (three times/week) (n = 32) or vehicle (n = 29).

Author(s): 
Hahm, Eun-Ryeong
Lee, Joomin
Kim, Su-Hyeong
Sehrawat, Anuradha
Arlotti, Julie A.
Shiva, Sruti S.
Bhargava, Rohit
Singh, Shivendra V.
Publication Title: 
Journal of the National Cancer Institute

BACKGROUND: Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS: Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA (three times/week) (n = 32) or vehicle (n = 29).

Author(s): 
Hahm, Eun-Ryeong
Lee, Joomin
Kim, Su-Hyeong
Sehrawat, Anuradha
Arlotti, Julie A.
Shiva, Sruti S.
Bhargava, Rohit
Singh, Shivendra V.
Publication Title: 
Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

Multiple periods of caloric restriction (or fasting)/refeeding in rodents have had inconsistent effects on mammary tumor (MT) development. In the present study, the consequence of intermittent caloric restriction/refeeding resulting in weight-cycling was evaluated using an oncogene-induced MT mouse model. Hybrid mouse MT virus-transforming growth factor alpha (MMTV-TGF-alpha)/Lep(+)Lep(ob) female mice were used. Ad libitum-fed mice (n = 30) were fed American Institute of Nutrition (AIN)-93M diet.

Author(s): 
Cleary, Margot P.
Jacobson, Michelle K.
Phillips, Frederick C.
Getzin, Susan C.
Grande, Joseph P.
Maihle, Nita J.
Publication Title: 
Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

Multiple periods of caloric restriction (or fasting)/refeeding in rodents have had inconsistent effects on mammary tumor (MT) development. In the present study, the consequence of intermittent caloric restriction/refeeding resulting in weight-cycling was evaluated using an oncogene-induced MT mouse model. Hybrid mouse MT virus-transforming growth factor alpha (MMTV-TGF-alpha)/Lep(+)Lep(ob) female mice were used. Ad libitum-fed mice (n = 30) were fed American Institute of Nutrition (AIN)-93M diet.

Author(s): 
Cleary, Margot P.
Jacobson, Michelle K.
Phillips, Frederick C.
Getzin, Susan C.
Grande, Joseph P.
Maihle, Nita J.
Publication Title: 
Endocrine-Related Cancer

Obesity is an established risk and progression factor for postmenopausal breast cancer. Interventions to decrease caloric intake and/or increase energy expenditure beneficially impact tumor progression in normoweight humans and animal models. However, despite the increasingly high global prevalence of obesity, the effects and underlying mechanisms of these energy balance modulating interventions are poorly characterized in obese individuals.

Author(s): 
Nogueira, Leticia M.
Dunlap, Sarah M.
Ford, Nikki A.
Hursting, Stephen D.
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