MAP Kinase Kinase Kinase 2

Publication Title: 
Molecular Cancer Therapeutics

Epidemiologic studies have suggested an inverse correlation between dietary intake of cruciferous vegetables and cancer risk. It is thus of interest to investigate the anticancer potential of phytochemicals presented in cruciferous vegetables. In this study, methyl-3-indolylacetate (MIA), a cruciferous indole for which the bioactivity has not been previously reported, was found to significantly suppress the invasion of cancer cells stimulated by the 12-O-tetradecanoyl-phorbol-13-acetate (TPA).

Author(s): 
Zhang, Siyuan
Li, Zhi
Wu, Ximei
Huang, Qing
Shen, Han-Ming
Ong, Choon-nam
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