Matrix Metalloproteinase 13

Publication Title: 
Pharmaceutical Biology

CONTEXT: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. OBJECTIVE: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. MATERIALS AND METHODS: The viability of human skin fibroblasts after incubation with T.

Author(s): 
Yakaew, Swanya
Itsarasook, Khwunjit
Ngoenkam, Jatuporn
Jessadayannamaetha, Arum
Viyoch, Jarupa
Ungsurungsie, Malyn
Publication Title: 
American Journal of Physiology. Cell Physiology

Fibrochondrocytes of meniscus adapt to changes in their biomechanical environment by mechanisms that are yet to be elucidated. In this study, the mechanoresponsiveness of fibrochondrocytes under normal and inflammatory conditions was investigated. Fibrochondrocytes from rat meniscus were exposed to dynamic tensile forces (DTF) at various magnitudes and frequencies. The mechanoresponsiveness was assessed by examining the expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), and matrix metalloproteinase-13 mRNA expression.

Author(s): 
Ferretti, Mario
Madhavan, Shashi
Deschner, James
Rath-Deschner, Birgit
Wypasek, Ewa
Agarwal, Sudha
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Exercise/joint mobilization is therapeutic for inflammatory joint diseases like rheumatoid and osteoarthritis, but the mechanisms underlying its actions remain poorly understood. We report that biomechanical signals at low/physiological magnitudes are potent inhibitors of inflammation induced by diverse proinflammatory activators like IL-1beta, TNF-alpha, and lipopolysaccharides, in fibrochondrocytes.

Author(s): 
Madhavan, Shashi
Anghelina, Mirela
Sjostrom, Danen
Dossumbekova, Anar
Guttridge, Denis C.
Agarwal, Sudha
Publication Title: 
Arthritis Research & Therapy

INTRODUCTION: The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) can activate chondrocytes and induce the production of proinflammatory cytokines and matrix metalloproteinases (MMPs). In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG) on AGE-modified-BSA (AGE-BSA)-induced activation and production of TNFalpha and MMP-13 in human OA chondrocytes.

Author(s): 
Rasheed, Zafar
Anbazhagan, Arivarasu N.
Akhtar, Nahid
Ramamurthy, Sangeetha
Voss, Frank R.
Haqqi, Tariq M.
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: Aberrant posttranscriptional regulation of matrix metalloproteinases (MMPs) by microRNA has emerged as an important factor in human diseases. The aim of this study was to determine whether the expression of MMP-13 in human osteoarthritis (OA) chondrocytes is regulated by microRNA. METHODS: Chondrocytes were stimulated with interleukin-1beta (IL-1beta) in vitro. Total RNA was prepared using TRIzol reagent. Polymerase chain reaction (PCR)-based arrays were used to determine the expression profile of 352 human microRNA.

Author(s): 
Akhtar, Nahid
Rasheed, Zafar
Ramamurthy, Sangeetha
Anbazhagan, Arivarasu N.
Voss, Frank R.
Haqqi, Tariq M.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To research the action mechanism of Yiqi Huayu Bushen Recipe (YHBR), a compound of traditional Chinese herbal medicine, in treating cervical syndrome (CS) with kidney deficiency in rats. METHODS: A total of 30 three-month-old female Sprague-Dawley rats were randomly divided into normal control group, CS with kidney deficiency model group (untreated group) and YHBR group, with 10 rats in each group.

Author(s): 
Jiang, Jian-chun
Li, Chen-Guang
Zhou, Quan
Bian, Qin
Liang, Qian-Qian
Cui, Xue-Jun
Lu, Sheng
Zhou, Chong-jian
Shi, Qi
Wang, Yong-Jun
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To study the efficacy and possible mechanism of Yiqi Huayu Recipe (YQHYR), a compound traditional Chinese herbal medicine, in preventing and treating degeneration of the articular cartilage in rats with osteoarthritis (OA). METHODS: A total of 90 one-month-old SD rats were randomly divided into normal control group, untreated group and YQHYR group, with 30 rats in each group. The osteoarthritis was induced by shoulder disarticulation plus upright posture in rats.

Author(s): 
Hou, Wei
Liang, Qian-Qian
He, Jian-Xin
Bian, Qin
Shi, Qi
Wang, Yong-Jun
Publication Title: 
Journal of Pharmacological Sciences

Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture.

Author(s): 
Liang, Qian-Qian
Xi, Zhi-Jie
Bian, Qin
Cui, Xue-Jun
Li, Chen-Guang
Hou, Wei
Shi, Qi
Wang, Yong-Jun
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