Matrix Metalloproteinases

Publication Title: 
The Journal of Surgical Research

BACKGROUND: Infection is a major problem in the management of wounds. Even though the development of synthetic antimicrobial agents persists, drug resistance and toxicity hinder their way. Many plants with multi-potent pharmaceutical activities may offer better treatment options, and Triphala (dried fruits of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica) are potential formulations evaluated for healing activity on infected wound as it possesses numerous activities.

Author(s): 
Kumar, Muthusamy Senthil
Kirubanandan, Shanmugam
Sripriya, Ramasamy
Sehgal, Praveen Kumar
Publication Title: 
Pharmaceutical Biology

CONTEXT: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. OBJECTIVE: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. MATERIALS AND METHODS: The viability of human skin fibroblasts after incubation with T.

Author(s): 
Yakaew, Swanya
Itsarasook, Khwunjit
Ngoenkam, Jatuporn
Jessadayannamaetha, Arum
Viyoch, Jarupa
Ungsurungsie, Malyn
Publication Title: 
Life Sciences

AIMS: Resveratrol, a silent information regulator 1 (SIRT1) activator, has been reported to act as an antioxidant contained in red wine and prevent the development of cardiovascular diseases. Histone deacetylase such as SIRT1 is involved in the regulation of lifespan extension. In this study, the effect of resveratrol on matrix metalloproteinases (MMPs) that play an important role in metastasis was examined in human fibrosarcoma cell line, HT1080. MAIN METHODS: The effect of resveratrol on MMPs' activity was evaluated using gelatin zymography.

Author(s): 
Lee, Soo-Jin
Kim, Moon-Moo
Publication Title: 
BMC research notes

BACKGROUND: Salacia reticulata (SR) is a plant native to Sri Lanka. In ayurvedic medicine, SR bark preparations, taken orally, are considered effective in the treatment of rheumatism and diabetes. We investigated the ability of SR leaves (SRL) to inhibit in vitro the interleukin-1β (IL-1β)-activated proliferation of synoviocyte-like cells derived from rheumatoid arthritis model mice. FINDINGS: Inflammatory synovial tissues were harvested from type II collagen antibody-induced arthritic mice. From these tissues, a synoviocyte-like cell line was established and named MTS-C H7.

Author(s): 
Sekiguchi, Yuusuke
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Kobata, Kenji
Wada, Masahiro
Publication Title: 
BMC research notes

BACKGROUND: Salacia reticulata (SR) is a plant native to Sri Lanka. In ayurvedic medicine, SR bark preparations, taken orally, are considered effective in the treatment of rheumatism and diabetes. We investigated the ability of SR leaves (SRL) to inhibit in vitro the interleukin-1β (IL-1β)-activated proliferation of synoviocyte-like cells derived from rheumatoid arthritis model mice. FINDINGS: Inflammatory synovial tissues were harvested from type II collagen antibody-induced arthritic mice. From these tissues, a synoviocyte-like cell line was established and named MTS-C H7.

Author(s): 
Sekiguchi, Yuusuke
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Kobata, Kenji
Wada, Masahiro
Publication Title: 
The Journal of Nutrition

Interleukin (IL)-1beta induces the expression of matrix metalloproteinases (MMPs) implicated in cartilage resorption and joint degradation in osteoarthritis (OA). Pomegranate fruit extract (PFE) was recently shown to exert anti-inflammatory effects in different disease models. However, no studies have been undertaken to investigate whether PFE constituents protect articular cartilage. In the present studies, OA chondrocytes or cartilage explants were pretreated with PFE and then stimulated with IL-1beta at different time points in vitro.

Author(s): 
Ahmed, Salahuddin
Wang, Naizhen
Hafeez, Bilal Bin
Cheruvu, Vinay K.
Haqqi, Tariq M.
Publication Title: 
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

OBJECTIVE: We sought to determine the molecular basis for the anticatabolic effects of mechanical signals on fibrocartilage cells by studying the expression of a variety of matrix metalloproteinases (MMPs). Furthermore, we examined whether the effects of biomechanical strain on MMP gene expression are sustained. METHODS: Fibrochondrocytes from temporomandibular joint (TMJ) discs were exposed to dynamic tensile strain for various time intervals in the presence of interleukin (IL)-1beta.

Author(s): 
Deschner, J.
Rath-Deschner, B.
Agarwal, S.
Publication Title: 
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

OBJECTIVES: Physical therapies are commonly used for limiting joint inflammation. To gain insight into their mechanisms of actions for optimal usage, we examined persistence of mechanical signals generated by cyclic tensile strain (CTS) in chondrocytes, in vitro. We hypothesized that mechanical signals induce anti-inflammatory and anabolic responses that are sustained over extended periods. METHODS: Articular chondrocytes obtained from rats were subjected to CTS for various time intervals followed by a period of rest, in the presence of interleukin-1beta (IL-1beta).

Author(s): 
Madhavan, S.
Anghelina, M.
Rath-Deschner, B.
Wypasek, E.
John, A.
Deschner, J.
Piesco, N.
Agarwal, S.
Publication Title: 
Cancer Research

We have shown previously that endogenous deficiency of interleukin (IL)-12 promotes photocarcinogenesis in mice. To characterize the role of IL-12 deficiency in tumor angiogenesis, we developed IL-12p35 knockout (IL-12 KO) mice on a C3H/HeN background. IL-12 KO mice and their wild-type (WT) counterparts were subjected to a photocarcinogenesis protocol. When tumor yield was stabilized, samples of tumor and tumor-uninvolved UVB-exposed skin were collected and subjected to immunohistochemistry, gelatinolytic zymography, real-time PCR, and Western blot analysis of angiogenic factors.

Author(s): 
Meeran, Syed M.
Katiyar, Suchitra
Elmets, Craig A.
Katiyar, Santosh K.
Publication Title: 
Atherosclerosis

Plasma sphingomyelin concentration is correlated with the development of atherosclerosis. It has been found to exist in significantly higher concentrations in aortic plaque. This appears to have clinical relevance as well as it has been shown to be an independent predictor of coronary artery disease. Ceramide, the backbone of sphingolipids, is the key component which affects atherosclerotic changes through its important second-messenger role.

Author(s): 
Bismuth, Jean
Lin, Peter
Yao, Qizhi
Chen, Changyi

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