MCF-7 Cells

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Breast cancer is the most common cancer diagnosed among women and is the second leading cause of cancer death. Homeopathic medicines are part of the alternative medicines that are given as a supportive therapy in breast cancer. The objective of this study was to investigate the anticancer activity of commercially available homeopathic preparations of Terminalia chebula (TC) and evaluate their nanoparticulate nature.

Author(s): 
Wani, Kirtee
Shah, Nilesh
Prabhune, Asmita
Jadhav, Arun
Ranjekar, Prabhakar
Kaul-Ghanekar, Ruchika
Publication Title: 
Oncotarget

Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previous studies established an important role of bromodomain-containing protein-4 (BRD4) in promoting estrogen-regulated transcription and proliferation of ER+ breast cancer cells.

Author(s): 
Nagarajan, Sankari
Benito, Eva
Fischer, Andre
Johnsen, Steven A.
Publication Title: 
Pharmacological reports: PR

BACKGROUND: Dihydroartemisinin (DHA) exhibits potent anti-malarial and anti-cancer activities. This study aimed to investigate the anti-proliferative effects of a combination of DHA and doxorubicin (DOX) on human breast cancer cells. METHODS: MTT assay and the combination index (CI) were used to show the anti-proliferative effects and calculate the synergism potential, respectively. Flow cytometry assay was used to detect apoptosis and the intracellular accumulation of DOX. JC-1 staining was used to determine the mitochondrial membrane potential.

Author(s): 
Wu, Guo-Sheng
Lu, Jin-Jian
Guo, Jia-Jie
Huang, Ming-Qing
Gan, Li
Chen, Xiu-Ping
Wang, Yi-Tao
Publication Title: 
Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

BACKGROUND: Artemisinin is the major sesquiterpene lactones in sweet wormwood (Artemisia annua L.), and its combination with transferrin exhibits versatile anti-cancer activities. Their non-selective targeting for cancer cells, however, limits their application. The aim of this study was to prepare the artemisinin and transferrin-loaded magnetic nanoliposomes in thermosensitive and non-thermosensitive forms and evaluate their antiproliferative activity against MCF-7 and MDA-MB-231 cells for better tumor-targeted therapy.

Author(s): 
Gharib, Amir
Faezizadeh, Zohreh
Mesbah-Namin, Seyed Ali Reza
Saravani, Ramin
Publication Title: 
ChemMedChem

In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine-sensitive and -resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 ?M).

Author(s): 
Suberu, John O.
Romero-Canelón, Isolda
Sullivan, Neil
Lapkin, Alexei A.
Barker, Guy C.
Publication Title: 
Breast Cancer Research and Treatment

Ayurvedic medicine plants continue to draw attention for the discovery of novel anticancer agents. Withaferin A (WA) is one such small-molecule constituent of the ayurvedic medicine plant Withania somnifera with efficacy against cultured and xenografted human breast cancer cells. However, the mechanism underlying anticancer effect of WA is not fully understood. This study was undertaken to determine the role of Notch signaling in anticancer effects of WA using human breast cancer cells as a model. Notably, Notch signaling is often hyperactive in human breast cancers.

Author(s): 
Lee, Joomin
Sehrawat, Anuradha
Singh, Shivendra V.
Publication Title: 
Breast Cancer Research and Treatment

Ayurvedic medicine plants continue to draw attention for the discovery of novel anticancer agents. Withaferin A (WA) is one such small-molecule constituent of the ayurvedic medicine plant Withania somnifera with efficacy against cultured and xenografted human breast cancer cells. However, the mechanism underlying anticancer effect of WA is not fully understood. This study was undertaken to determine the role of Notch signaling in anticancer effects of WA using human breast cancer cells as a model. Notably, Notch signaling is often hyperactive in human breast cancers.

Author(s): 
Lee, Joomin
Sehrawat, Anuradha
Singh, Shivendra V.
Publication Title: 
Journal of Natural Medicines

Njavara is an important medicinal rice variety of Kerala, India widely used in Ayurveda for the treatment of rheumatoid arthritis, paralysis, neurodegenerative diseases and in rejuvenation therapy. The study evaluated, for the first time, antitumor effects of the two rare flavonolignans, tricin 4'-O-(erythro-β-guaiacylglyceryl) ether (compound 1) and tricin 4'-O-(threo-β-guaiacylglyceryl) ether (compound 2), isolated from 'Njavara' black.

Author(s): 
Mohanlal, Smitha
Maney, Sathish Kumar
Santhoshkumar, Thankayyan Retnabai
Jayalekshmy, Ananthasankaran
Publication Title: 
Hormones & Cancer

Estrogen receptor α (ERα) is present in about 70 % of human breast cancers and, working in conjunction with extracellular signal-regulated kinase 2 (ERK2), this nuclear hormone receptor regulates the expression of many protein-encoding genes. Given the crucial roles of miRNAs in cancer biology, we investigated the regulation of miRNAs by estradiol (E2) through ERα and ERK2, and their impact on target gene expression and phenotypic properties of breast cancer cells.

Author(s): 
Kim, Kyuri
Madak-Erdogan, Zeynep
Ventrella, Rosa
Katzenellenbogen, Benita S.
Publication Title: 
Journal of Agricultural and Food Chemistry

Bioactive components in food plants can undergo dynamic processes that involve multiple chemical species. For example, 2'-hydroxychalcones can readily isomerize into flavanones. Although chemically well documented, this reaction has barely been explored in the context of cell-based assays.

Author(s): 
Simmler, Charlotte
Hajirahimkhan, Atieh
Lankin, David C.
Bolton, Judy L.
Jones, Tristesse
Soejarto, Djaja D.
Chen, Shao-Nong
Pauli, Guido F.

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