Memory, Short-Term

Publication Title: 
The Journal of Head Trauma Rehabilitation

INTRODUCTION: Traumatic brain injury, due to its diffuse nature and high frequency of injury to frontotemporal and midbrain reticular activating systems, may cause disruption in many aspects of attention: arousal, selective attention, speed of information processing, and strategic control of attention, including sustained attention, shifting and dividing of attention, and working memory. An international team of researchers and clinicians (known as INCOG) convened to develop recommendations for the management of attentional problems.

Author(s): 
Ponsford, Jennie
Bayley, Mark
Wiseman-Hakes, Catherine
Togher, Leanne
Velikonja, Diana
McIntyre, Amanda
Janzen, Shannon
Tate, Robyn
INCOG Expert Panel
Publication Title: 
Physiology & Behavior

Ketogenic diets are high in fat and low in carbohydrates, and have long been used as an anticonvulsant therapy for drug-intractable and pediatric epilepsy. Additionally, ketogenic diets have been shown to provide neuroprotective effects against acute and chronic brain injury, including beneficial effects in various rodent models of neurodegeneration. Huntington's disease is a progressive neurodegenerative disease characterized by neurological, behavioral and metabolic dysfunction, and ketogenic diets have been shown to increase energy molecules and mitochondrial function.

Author(s): 
Ruskin, David N.
Ross, Jessica L.
Kawamura, Masahito
Ruiz, Tiffany L.
Geiger, Jonathan D.
Masino, Susan A.
Publication Title: 
PloS One

Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed.

Author(s): 
Kuhla, Angela
Lange, Sophie
Holzmann, Carsten
Maass, Fabian
Petersen, Jana
Vollmar, Brigitte
Wree, Andreas
Publication Title: 
Epigenetics

Many genetic studies report mixed results both for the associations between COMT polymorphisms and schizophrenia and for the effects of COMT variants on common intermediate phenotypes of the disorder. Reasons for this may include small genetic effect sizes and the modulation of environmental influences.

Author(s): 
Walton, Esther
Liu, Jingyu
Hass, Johanna
White, Tonya
Scholz, Markus
Roessner, Veit
Gollub, Randy
Calhoun, Vince D.
Ehrlich, Stefan
Publication Title: 
Biological Psychiatry

BACKGROUND: Early life stress (ELS) experience is associated with persisting working memory (WM) deficits; changes to the corticotropin-releasing hormone (CRH) system; and structural, functional, and epigenetic changes in the hippocampus. Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.

Author(s): 
Fuge, Philipp
Aust, Sabine
Fan, Yan
Weigand, Anne
G‰rtner, Matti
Feeser, Melanie
Bajbouj, Malek
Grimm, Simone
Publication Title: 
PloS One

Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance.

Author(s): 
CÛrdova-Palomera, Aldo
Alemany, Silvia
FatjÛ-Vilas, Mar
Goldberg, Ximena
Leza, Juan Carlos
Gonz·lez-Pinto, Ana
Nenadic, Igor
FaÒan·s, Lourdes
Publication Title: 
European Psychiatry: The Journal of the Association of European Psychiatrists

BACKGROUND: Though cognitive abilities in adulthood are largely influenced by individual genetic background, they have also been shown to be importantly influenced by environmental factors. Some of these influences are mediated by epigenetic mechanisms. Accordingly, polymorphic variants in the epigenetic gene DNMT3B have been linked to neurocognitive performance.

Author(s): 
CÛrdova-Palomera, A.
FatjÛ-Vilas, M.
Kebir, O.
GastÛ, C.
Krebs, M. O.
FaÒan·s, L.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: Fetal alcohol spectrum disorders (FASDs) are conditions characterized by physical anomalies, neurodevelopmental abnormalities, and neurocognitive deficits, including intellectual, executive, and memory deficits. There are no specific biological treatments for FASDs, but rodent models have shown that prenatal or postnatal choline supplementation reduces cognitive and behavioral deficits. Potential mechanisms include phospholipid production for axonal growth and myelination, acetylcholine enhancement, and epigenetic effects.

Author(s): 
Wozniak, Jeffrey R.
Fuglestad, Anita J.
Eckerle, Judith K.
Fink, Birgit A.
Hoecker, Heather L.
Boys, Christopher J.
Radke, Joshua P.
Kroupina, Maria G.
Miller, Neely C.
Brearley, Ann M.
Zeisel, Steven H.
Georgieff, Michael K.
Publication Title: 
Epigenetics

Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val(66)Met), which creates or abolishes a CpG dinucleotide for DNA methylation.

Author(s): 
Ursini, Gianluca
Cavalleri, Tommaso
Fazio, Leonardo
Angrisano, Tiziana
Iacovelli, Luisa
Porcelli, Annamaria
Maddalena, Giancarlo
Punzi, Giovanna
Mancini, Marina
Gelao, Barbara
Romano, Raffaella
Masellis, Rita
Calabrese, Francesca
Rampino, Antonio
Taurisano, Paolo
Di Giorgio, Annabella
Keller, Simona
Tarantini, Letizia
Sinibaldi, Lorenzo
Quarto, Tiziana
Popolizio, Teresa
Caforio, Grazia
Blasi, Giuseppe
Riva, Marco A.
De Blasi, Antonio
Chiariotti, Lorenzo
Bollati, Valentina
Bertolino, Alessandro
Publication Title: 
The Journal of Psychology

This study explored the relationship among love deprivation, Performance greater than Verbal discrepancy, and violent crime in a sample of juvenile probationers. Love deprivation and P greater than V discrepancy was significantly related to violent delinquency after adjusting for the effects of both race and social class, two variables often closely associated with violent delinquency. Also, love deprivation was strongly related to P greater than V discrepancy.

Author(s): 
Walsh, A.
Beyer, J. A.
Petee, T. A.

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