Mental Status Schedule

Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Families of centenarians have high levels of plasma high-density lipoprotein (HDL) cholesterol, which may have neurological as well as cardiovascular protective effects during aging. Because plasma HDL level declines progressively with aging, we examined whether centenarians with higher plasma HDL levels have better cognitive function.

Author(s): 
Atzmon, Gil
Gabriely, Ilan
Greiner, William
Davidson, Deborah
Schechter, Clyde
Barzilai, Nir
Publication Title: 
Annali Italiani Di Medicina Interna: Organo Ufficiale Della Societ‡ Italiana Di Medicina Interna

The progressive lengthening of the average life span and the expanding elderly population high-light the phenomenon of "centenarianism" or extreme longevity in Italy. A large number of Italian Geriatric and Gerontology Centers throughout Italy have joined in the Italian Multicenter Study on Centenarians which evaluates the clinical and biological conditions of centenarians. A census of centenarians in Italy as of December 31, 1993 is presently in course. Preliminary data indicate that about 6000 subjects were alive on that day.

Author(s): 
Receputo, G.
Rapisarda, R.
Motta, L.
Publication Title: 
Neuroscience Letters

Disturbance of circadian gene regulation might contribute to behavioral and psychological symptoms in dementia patients. This study was to evaluate the CpG island methylation status on the circadian gene promoters in dementia patients.

Author(s): 
Liu, Hsing-Cheng
Hu, Chaur-Jong
Tang, Yun-Chin
Chang, Jan-Gowth
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

Multiple genetic approaches have identified microRNAs as key effectors in psychiatric disorders as they post-transcriptionally regulate expression of thousands of target genes. However, their role in specific psychiatric diseases remains poorly understood. In addition, epigenetic mechanisms such as DNA methylation, which affect the expression of both microRNAs and coding genes, are critical for our understanding of molecular mechanisms in schizophrenia.

Author(s): 
Hass, Johanna
Walton, Esther
Wright, Carrie
Beyer, Andreas
Scholz, Markus
Turner, Jessica
Liu, Jingyu
Smolka, Michael N.
Roessner, Veit
Sponheim, Scott R.
Gollub, Randy L.
Calhoun, Vince D.
Ehrlich, Stefan
Publication Title: 
Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition

An estimated 65% of individuals demonstrate multidomain cognitive impairment poststroke, although little is known about the varying role of cognitive risk and protective factors in preischemic, peri-ischemic, and postischemic stroke phases. Longitudinal changes in global cognitive function after ischemic stroke are not well characterized, especially in older adults over age 80.

Author(s): 
Vaughan, Leslie
Bushnell, Cheryl
Bell, Christina L.
Espeland, Mark A.
Publication Title: 
Health Services Research

Many patients with emotional disorders receive their mental health care from general medical physicians. In this article, we examine differences in costs and style between mental health care delivered by mental health specialists and that provided by general medical physicians, and the sensitivity to insurance of the patient's choice of mental health care provider. We use data from a randomized trial of cost-sharing, the RAND Health Insurance Experiment.

Author(s): 
Wells, K. B.
Manning, W. G.
Duan, N.
Newhouse, J. P.
Ware, J. E.
Publication Title: 
Anesthesia and Analgesia

We evaluated the cognitive recovery profiles in elderly patients after general anesthesia with desflurane or sevoflurane. After IRB approval, 70 ASA physical status I-III consenting elderly patients (> or =65 yr old) undergoing total knee or hip replacement procedures were randomly assigned to one of two general anesthetic groups. Propofol and fentanyl were administered for induction of anesthesia, followed by either desflurane 2%-4% or sevoflurane 1%-1.5% with nitrous oxide 65% in oxygen. The desflurane (2.5 +/- 0.6 MAC. h) and sevoflurane (2.7 +/- 0.5 MAC.

Author(s): 
Chen, X.
Zhao, M.
White, P. F.
Li, S.
Tang, J.
Wender, R. H.
Sloninsky, A.
Naruse, R.
Kariger, R.
Webb, T.
Norel, E.
Publication Title: 
Aging & Mental Health

OBJECTIVES: To examine the association of cognitive function with use of non-prescribed therapies for managing acute and chronic conditions, and to determine whether use of non-prescribed therapies changes over time in relation to baseline cognitive function. METHODS: 200 community-dwelling adults aged 65 and older were recruited from three counties in south central North Carolina. Repeated measures of daily symptoms and treatment were collected on three consecutive days at intervals of at least one month.

Author(s): 
Nguyen, Ha T.
Grzywacz, Joseph G.
Quandt, Sara A.
Neiberg, Rebecca H.
Lang, Wei
Altizer, Kathryn
Stoller, Eleanor P.
Bell, Ronny A.
Arcury, Thomas A.
Publication Title: 
Aging & Mental Health

OBJECTIVES: To examine the association of cognitive function with use of non-prescribed therapies for managing acute and chronic conditions, and to determine whether use of non-prescribed therapies changes over time in relation to baseline cognitive function. METHODS: 200 community-dwelling adults aged 65 and older were recruited from three counties in south central North Carolina. Repeated measures of daily symptoms and treatment were collected on three consecutive days at intervals of at least one month.

Author(s): 
Nguyen, Ha T.
Grzywacz, Joseph G.
Quandt, Sara A.
Neiberg, Rebecca H.
Lang, Wei
Altizer, Kathryn
Stoller, Eleanor P.
Bell, Ronny A.
Arcury, Thomas A.
Publication Title: 
Biological Psychiatry

BACKGROUND: Attentional control of executive cognitive function (ECF) decreases in older individuals with Alzheimer Disease (AD). In order to examine early AD-related changes in the neural substrates of ECF attentional control, we measured activation dorsolateral prefrontal (dLPFC), posterior parietal (PPC), and anterior cingulate cortex (ACC) in adults with mild cognitively impairment (MCI) and in cognitively normal (CN) adults.

Author(s): 
Rosano, Caterina
Aizenstein, Howard J.
Cochran, Jennifer L.
Saxton, Judith A.
De Kosky, Steven T.
Newman, Anne B.
Kuller, Lewis H.
Lopez, Oscar L.
Carter, Cameron S.

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