Mesenchymal Stem Cell Transplantation

Publication Title: 
Journal of Dental Research

Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases. Recently, a novel MSC population was identified from dental pulp of human supernumerary teeth, and its multipotency characterized. Herein, we first examined the in vitro and in vivo immunomodulatory functions of human supernumerary tooth-derived stem cells (SNTSCs).

Author(s): 
Makino, Y.
Yamaza, H.
Akiyama, K.
Ma, L.
Hoshino, Y.
Nonaka, K.
Terada, Y.
Kukita, T.
Shi, S.
Yamaza, T.
Publication Title: 
Molecular Therapy: The Journal of the American Society of Gene Therapy

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord. We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell line-derived neurotrophic factor (GDNF) decrease disease progression in a rat model of ALS when delivered to skeletal muscle. In the current study, we determined whether or not this effect could be enhanced by delivering GDNF in concert with other trophic factors.

Author(s): 
Krakora, Dan
Mulcrone, Patrick
Meyer, Michael
Lewis, Christina
Bernau, Ksenija
Gowing, Genevieve
Zimprich, Chad
Aebischer, Patrick
Svendsen, Clive N.
Suzuki, Masatoshi
Publication Title: 
Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research

Efficient osteogenic differentiation and bone formation from mesenchymal stem cells (MSCs) should have clinical applications in treating nonunion fracture healing. MSCs are adherent bone marrow stromal cells that can self-renew and differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages. We have identified bone morphogenetic protein 9 (BMP-9) as one of the most osteogenic BMPs. Here we investigate the effect of insulin-like growth factor 2 (IGF-2) on BMP-9-induced bone formation. We have found that endogenous IGF-2 expression is low in MSCs.

Author(s): 
Chen, Liang
Jiang, Wei
Huang, Jiayi
He, Bai-Cheng
Zuo, Guo-Wei
Zhang, Wenli
Luo, Qing
Shi, Qiong
Zhang, Bing-Qiang
Wagner, Eric R.
Luo, Jinyong
Tang, Min
Wietholt, Christian
Luo, Xiaoji
Bi, Yang
Su, Yuxi
Liu, Bo
Kim, Stephanie H.
He, Connie J.
Hu, Yawen
Shen, Jikun
Rastegar, Farbod
Huang, Enyi
Gao, Yanhong
Gao, Jian-Li
Zhou, Jian-Zhong
Reid, Russell R.
Luu, Hue H.
Haydon, Rex C.
He, Tong-Chuan
Deng, Zhong-Liang
Publication Title: 
Frontiers in Bioscience (Scholar Edition)

The incidence and prevalence of Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), are rising. According to some estimates >1 million new cases of IBD arise in the United States annually. The conventional therapies available for IBD range from anti-inflammatory drugs to immunosuppressive agents, but these therapies generally fail to achieve satisfactory results due to their side effects.

Author(s): 
Singh, Udai P.
Singh, Narendra P.
Singh, Balwan
Mishra, Manoj K.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Singh, Shree Ram
Publication Title: 
Stem Cells and Development

Prenatal transplantation of genetically engineered mesenchymal stem cells (MSCs) might benefit prevention or treatment of early-onset genetic disorders due to the cells' intrinsic regenerative potential plus the acquired advantage from therapeutic transgene expression. However, a thorough assessment of the safety, accessibility, and behavior of these MSCs in the fetal environment using appropriate animal models is required before we can advance toward a clinical application.

Author(s): 
Moreno, Rafael
Martínez-González, Itziar
Rosal, Marta
Nadal, Marga
Petriz, Jordi
Gratacós, Eduard
Aran, Josep M.
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture (EA) and human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied.

Author(s): 
Yang, Zhuoxin
Chen, Pengdian
Yu, Haibo
Luo, Wenshu
Pi, Min
Wu, Yonggang
Wang, Ling
Yang, Fuxia
Gou, Yanhua
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