Metabolic Networks and Pathways

Publication Title: 
Biochimica Et Biophysica Acta

This review describes our current understanding of the "traffic lights" that regulate sulfur flow through the methionine bionetwork in liver, which supplies two major homeostatic systems governing cellular methylation and antioxidant potential. Theoretical concepts derived from mathematical modeling of this metabolic nexus provide insights into the properties of this system, some of which seem to be paradoxical at first glance. Cellular needs supported by this network are met by use of parallel metabolic tracks that are differentially controlled by intermediates in the pathway.

Author(s): 
Martinov, M. V.
Vitvitsky, V. M.
Banerjee, R.
Ataullakhanov, F. I.
Publication Title: 
Aging

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms.

Author(s): 
Tucci, Paola
Publication Title: 
Rejuvenation Research

Polyamines (putrescine, spermidine, and spermine) are a family of molecules that derive from ornithine through a decarboxylation process. They are essential for cell growth and proliferation, stabilization of negative charges of DNA, RNA transcription, translation, and apoptosis. Recently, it has been demonstrated that exogenously administered spermidine promotes longevity in yeasts, flies, worms, and human cultured immune cells.

Author(s): 
Pucciarelli, Stefania
Moreschini, Benedetta
Micozzi, Daniela
De Fronzo, Giusi S.
Carpi, Francesco M.
Polzonetti, Valeria
Vincenzetti, Silvia
Mignini, Fiorenzo
Napolioni, Valerio
Publication Title: 
Aging

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms.

Author(s): 
Tucci, Paola
Publication Title: 
The Oncologist

Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer.

Author(s): 
Champ, Colin E.
Baserga, Renato
Mishra, Mark V.
Jin, Lianjin
Sotgia, Federica
Lisanti, Michael P.
Pestell, Richard G.
Dicker, Adam P.
Simone, Nicole L.
Publication Title: 
Current Opinion in Cell Biology

Over 40 years ago, Francois Jacob proposed that levels of 'integrons' explain how biological systems are constructed. Today, these networks of interactions between tissues, cells, organelles, metabolic pathways, genes, and individual molecules provide key insights into biology. We suggest that the wiring and interdependency between subsystems within a network are useful to understand the aging process. The breakdown of one subsystem (e.g. an organelle) can have ramifications for other interconnected subsystems, leading to the sequential collapse of subsystem functions.

Author(s): 
Dillin, Andrew
Gottschling, Daniel E.
Nystrˆm, Thomas
Publication Title: 
Hormone Research

Background: The process of aging is associated with progressive remodeling. The age-dependent remodeling process mainly affects anthropometrics and endocrine function, which subsequently impact metabolic factors. In some individuals, e.g., the very select group of healthy centenarians, the remodeling process is successful.

Author(s): 
Barbieri, Michelangela
Boccardi, Virginia
Papa, Michela
Paolisso, Giuseppe
Publication Title: 
Aging

Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms.

Author(s): 
Tucci, Paola
Publication Title: 
BMC microbiology

BACKGROUND: Studies with the nematode model Caenorhabditis elegans have identified conserved biochemical pathways that act to modulate life span. Life span can also be influenced by the composition of the intestinal microbiome, and C. elegans life span can be dramatically influenced by its diet of Escherichia coli. Although C. elegans is typically fed the standard OP50 strain of E. coli, nematodes fed E. coli strains rendered respiratory deficient, either due to a lack coenzyme Q or the absence of ATP synthase, show significant life span extension.

Author(s): 
Gomez, Fernando
Monsalve, Gabriela C.
Tse, Vincent
Saiki, Ryoichi
Weng, Emily
Lee, Laura
Srinivasan, Chandra
Frand, Alison R.
Clarke, Catherine F.
Publication Title: 
The Oncologist

Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer.

Author(s): 
Champ, Colin E.
Baserga, Renato
Mishra, Mark V.
Jin, Lianjin
Sotgia, Federica
Lisanti, Michael P.
Pestell, Richard G.
Dicker, Adam P.
Simone, Nicole L.

Pages

Subscribe to RSS - Metabolic Networks and Pathways