Metabolomics

Publication Title: 
PloS One

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals.

Author(s): 
Collino, Sebastiano
Montoliu, Ivan
Martin, FranÁois-Pierre J.
Scherer, Max
Mari, Daniela
Salvioli, Stefano
Bucci, Laura
Ostan, Rita
Monti, Daniela
Biagi, Elena
Brigidi, Patrizia
Franceschi, Claudio
Rezzi, Serge
Publication Title: 
PloS One

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals.

Author(s): 
Collino, Sebastiano
Montoliu, Ivan
Martin, FranÁois-Pierre J.
Scherer, Max
Mari, Daniela
Salvioli, Stefano
Bucci, Laura
Ostan, Rita
Monti, Daniela
Biagi, Elena
Brigidi, Patrizia
Franceschi, Claudio
Rezzi, Serge
Publication Title: 
Nature Reviews. Genetics

The classical twin study has been a powerful heuristic in biomedical, psychiatric and behavioural research for decades. Twin registries worldwide have collected biological material and longitudinal phenotypic data on tens of thousands of twins, providing a valuable resource for studying complex phenotypes and their underlying biology. In this Review, we consider the continuing value of twin studies in the current era of molecular genetic studies.

Author(s): 
van Dongen, Jenny
Slagboom, P. Eline
Draisma, Harmen H. M.
Martin, Nicholas G.
Boomsma, Dorret I.
Publication Title: 
Advances in Clinical Chemistry

Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even psychotic symptoms and signs that can cause substantial impairments in quality of life and functioning. Biomarkers are measurable indicators that could help diagnosing MDD or predicting treatment response. In this chapter, lipid profiles, immune/inflammation, and neurotrophic factor pathways that have long been implicated in the pathogenesis of MDD are discussed.

Author(s): 
Huang, Tiao-Lai
Lin, Chin-Chuen
Publication Title: 
Current Opinion in Biotechnology

The technologies of metagenomics and metabolomics are broadening our knowledge of the roles the human gut microbiota play in health and disease. For many years now, probiotics and prebiotics have been included in foods for their health benefits; however, we have only recently begun to understand their modes of action. This review highlights recent advances in deciphering the mechanisms of probiosis and prebiosis, and describes how this knowledge could be transferred to select for enhancing functional foods targeting different populations.

Author(s): 
Saulnier, Delphine M. A.
Spinler, Jennifer K.
Gibson, Glenn R.
Versalovic, James
Publication Title: 
Journal of Magnetic Resonance (San Diego, Calif.: 1997)

For mass-limited samples, the residual sample volume outside the detection coil is an important concern, as is good base line resolution. Here, we present the construction and evaluation of magnetic susceptibility-matched plugs for microcoil NMR sample cells which address these issues. Mixed-epoxy glue and ultem tube plugs that have susceptibility values close to those of perfluorocarbon FC-43 (fluorinert) and copper were used in small volume (0.5-2 microL) and larger volume (15-20 microL) thin glass capillary sample cells. Using these plugs, the sample volume efficiency (i.e.

Author(s): 
Kc, Ravi
Gowda, Yashas N.
Djukovic, Danijel
Henry, Ian D.
Park, Gregory H. J.
Raftery, Daniel
Publication Title: 
Journal of Proteome Research

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in most western countries. Current NAFLD diagnosis methods (e.g., liver biopsy analysis or imaging techniques) are poorly suited as tests for such a prevalent condition, from both a clinical and financial point of view. The present work aims to demonstrate the potential utility of serum metabolic profiling in defining phenotypic biomarkers that could be useful in NAFLD management.

Author(s): 
Barr, Jonathan
Vázquez-Chantada, Mercedes
Alonso, Cristina
Perez-Cormenzana, Miriam
Mayo, Rebeca
Galán, Asier
Caballeria, Juan
Martín-Duce, Antonio
Tran, Albert
Wagner, Conrad
Luka, Zigmund
Lu, Shelly C.
Castro, Azucena
Le Marchand-Brustel, Yannick
Martínez-Chantar, M. Luz
Veyrie, Nicolas
Clément, Karine
Tordjman, Joan
Gual, Philippe
Mato, José M.
Publication Title: 
Clinical Biochemistry

Tracer-based metabolomics is a systems biology tool that combines advances in tracer methodology for physiological studies, high throughput "-omics" technologies and constraint based modeling of metabolic networks. It is different from the commonly known metabolomics or metabonomics in that it is a targeted approach based on a metabolic network model in cells.

Author(s): 
Paul Lee, W.-N.
Wahjudi, Paulin N.
Xu, Jun
Go, Vay Liang
Publication Title: 
Annual Review of Nutrition

Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis. Omega-3 and -6 PUFAs are key components of biomembranes and play important roles in cell integrity, development, maintenance, and function. The essential omega-3 fatty acid family member docosahexaenoic acid (DHA) is avidly retained and uniquely concentrated in the nervous system, particularly in photoreceptors and synaptic membranes. DHA plays a key role in vision, neuroprotection, successful aging, memory, and other functions.

Author(s): 
Bazan, Nicolas G.
Molina, Miguel F.
Gordon, William C.
Publication Title: 
The Journal of Biological Chemistry

Neuroinflammation and traumatic brain injury involve activation of inflammatory cells and production of local pro-inflammatory mediators that can amplify tissue damage. Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the single-cell level in microfluidic chambers, we identified a series of novel bioactive oxygenated docosahexaenoyl ethanolamide- (DHEA) derived products that regulated leukocyte motility.

Author(s): 
Yang, Rong
Fredman, Gabrielle
Krishnamoorthy, Sriram
Agrawal, Nitin
Irimia, Daniel
Piomelli, Daniele
Serhan, Charles N.

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