Metal Nanoparticles

Publication Title: 
Journal of Biomedical Nanotechnology

The validity of herbometallic bhasmas described in Ayurveda is nowhere acknowledged by biomedical science. To unravel the knowledge of bhasmas, an algorithm integrating ayurveda- and science-based experiments needs to connect the basic science of rasa shastra, the study of herbometallic medicines in ayurveda, to clinical data.

Author(s): 
Bhattacharya, Bhaswati
Publication Title: 
Journal of Biomedical Nanotechnology

Ayurveda is one of the oldest systems of medicine, practiced in Indian sub continent. We are working to calibrate classical parameters of good manufacturing practices of Ayurvedic bhasma on parameters and language of contemporary science. Bhasma in accordance of classical expectation are Swarna bhasma, Makshika bhasma, Abhrak bhasma, Tamra bhasma and Louha bhasma. X-ray diffraction, TEM and particle size analysis revealed that these bhasma are in nanometer dimension. These bhasma may be considered as nanomedicine and are free from toxicity in therapeutic doses.

Author(s): 
Chaudhary, Anand
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Biologically inspired experimental process in synthesising nanoparticles is of great interest in present scenario. Biosynthesis of nanoparticles is considered to be one of the best green techniques in synthesising metal nanoparticles. Here, an in situ green biogenic synthesis of gold nanoparticles using aqueous extracts of Terminalia chebula as reducing and stabilizing agent is reported. Gold nanoparticles were confirmed by surface plasmon resonance in the range of 535 nm using UV-visible spectrometry.

Author(s): 
Kumar, Kesarla Mohan
Mandal, Badal Kumar
Sinha, Madhulika
Krishnakumar, Varadhan
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green rapid biogenic synthesis of silver nanoparticles (Ag NPs) using Terminalia chebula (T. chebula) aqueous extract was demonstrated in this present study. The formation of silver nanoparticles was confirmed by Surface Plasmon Resonance (SPR) at 452 nm using UV-visible spectrophotometer. The reduction of silver ions to silver nanoparticles by T. chebula extract was completed within 20 min which was evidenced potentiometrically.

Author(s): 
Mohan Kumar, Kesarla
Sinha, Madhulika
Mandal, Badal Kumar
Ghosh, Asit Ranjan
Siva Kumar, Koppala
Sreedhara Reddy, Pamanji
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

There are many methods to synthesise metal and metal oxide nanoparticles (NPs) using different reducing agents which are hazardous in nature. Although some researchers have used biobased materials for synthesis of these NPs, further research is needed in this area. To explore the scope of bio-extract for the synthesis of transition metal NPs, the present paper synthesises metal NPs replacing hazardous traditional reducing agents. This paper reports the synthesis of palladium and iron NPs, using aqueous extract of Terminalia chebula fruit.

Author(s): 
Mohan Kumar, Kesarla
Mandal, Badal Kumar
Siva Kumar, Koppala
Sreedhara Reddy, Pamanji
Sreedhar, Bojja
Publication Title: 
International Journal of Nanomedicine

Platinum nanoparticle (Pt-np) species are superoxide dismutase/catalase mimetics and also have an activity similar to that of mitochondrial electron transport complex I. To examine if this complex I-like activity functions in vivo, we studied the effects of Pt-nps on the lifespan of a mitochondrial complex I-deficient Caenorhabditis elegans mutant, nuo-1 (LB25) compared with wild-type N2. We synthesized a fusion protein of a cell-penetrating peptide, human immunodeficiency virus-1 TAT (48-60), C-terminally linked to a peptide with a high affinity to platinum (GRKKRRQRRRPPQ-DRTSTWR).

Author(s): 
Sakaue, Yuri
Kim, Juewon
Miyamoto, Yusei
Publication Title: 
Journal of Biomedical Nanotechnology

The validity of herbometallic bhasmas described in Ayurveda is nowhere acknowledged by biomedical science. To unravel the knowledge of bhasmas, an algorithm integrating ayurveda- and science-based experiments needs to connect the basic science of rasa shastra, the study of herbometallic medicines in ayurveda, to clinical data.

Author(s): 
Bhattacharya, Bhaswati
Publication Title: 
Journal of Biomedical Nanotechnology

Ayurveda is one of the oldest systems of medicine, practiced in Indian sub continent. We are working to calibrate classical parameters of good manufacturing practices of Ayurvedic bhasma on parameters and language of contemporary science. Bhasma in accordance of classical expectation are Swarna bhasma, Makshika bhasma, Abhrak bhasma, Tamra bhasma and Louha bhasma. X-ray diffraction, TEM and particle size analysis revealed that these bhasma are in nanometer dimension. These bhasma may be considered as nanomedicine and are free from toxicity in therapeutic doses.

Author(s): 
Chaudhary, Anand
Publication Title: 
Journal of Biomedical Nanotechnology

Bhasmas are unique Ayurvedic metallic preparations used for medicinal purposes since ancient times. With increasing knowledge of risk of nanomaterials, it becomes imperative to assess the safety of nanoparticulate Ayurvedic medicines using toxicity models. In this study, zinc bhasma was characterized using modern physicochemical techniques. In vitro toxicity test revealed no major cytotoxicity at all the dose levels tested. No behavioral abnormality, clinical signs and mortality was seen indicating no adverse effects.

Author(s): 
Umrani, Rinku D.
Paknikar, Kishore M.
Publication Title: 
Journal of Applied Microbiology

In the present scenario, pharmaceutical and biomedical sectors are facing the challenges of continuous increase in the multidrug-resistant (MDR) human pathogenic microbes. Re-emergence of MDR microbes is facilitated by drug and/or antibiotic resistance, which is acquired way of microbes for their survival and multiplication in uncomfortable environments. MDR bacterial infections lead to significant increase in mortality, morbidity and cost of prolonged treatments.

Author(s): 
Rai, M. K.
Deshmukh, S. D.
Ingle, A. P.
Gade, A. K.

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