Metaplasia

Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized. OBJECTIVE: To evaluate lung inflammation, mucus metaplasia and AHR in relationship with age in murine models of allergic asthma comparing young and older mice. METHODS: Young (6 weeks) and older (6, 12, 18 months) BALB/c mice were sensitized and challenged with ovalbumin (OVA).

Author(s): 
Busse, Paula J.
Zhang, Teng Fei
Srivastava, Kamal
Schofield, Brian
Li, Xiu-Min
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Viral infection is associated with approximately one-half of acute exacerbations of chronic obstructive pulmonary disease (COPD), which in turn, accelerate disease progression. In this study, we infected mice exposed to a combination of elastase and LPS, a constituent of cigarette smoke and a risk factor for development of COPD, with rhinovirus serotype 1B, and examined animals for viral persistence, airway resistance, lung volume, and cytokine responses.

Author(s): 
Sajjan, Umadevi
Ganesan, Shyamala
Comstock, Adam T.
Shim, Jee
Wang, Qiong
Nagarkar, Deepti R.
Zhao, Ying
Goldsmith, Adam M.
Sonstein, Joanne
Linn, Marisa J.
Curtis, Jeffrey L.
Hershenson, Marc B.
Publication Title: 
Laboratory Investigation; a Journal of Technical Methods and Pathology

Pancreatic cancer occurs in the setting of a profound fibrotic microenvironment that often dwarfs the actual tumor. Although pancreatic fibrosis has been well studied in chronic pancreatitis, its development in pancreatic cancer is much less well understood. This article describes the dynamic remodeling that occurs from pancreatic precursors (pancreatic intraepithelial neoplasias (PanINs)) to pancreatic ductal adenocarcinoma, highlighting similarities and differences between benign and malignant disease.

Author(s): 
Shi, Chanjuan
Washington, M. Kay
Chaturvedi, Rupesh
Drosos, Yiannis
Revetta, Frank L.
Weaver, Connie J.
Buzhardt, Emily
Yull, Fiona E.
Blackwell, Timothy S.
Sosa-Pineda, Beatriz
Whitehead, Robert H.
Beauchamp, R. Daniel
Wilson, Keith T.
Means, Anna L.
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