Methanol

Publication Title: 
Applied Biochemistry and Biotechnology

Sol/gel-derived silica gel was prepared at room temperature from tetraethyl orthosilicate precursor. The extracts of Terminalia chebula (Haritoki) were entrapped into the porous silica gel. Fourier transform infrared analysis revealed the proper adsorption of herbal values in the nanopores of the silica gel. Porosity was estimated by transmission electron microscope studies. The release kinetics of the extract in both 0.1 N HCl, pH 1.2, and Phosphate-buffer saline (PBS), pH 7.2, were determined using UV-Vis spectroscopy.

Author(s): 
Chakraborty, Suparna
Mitra, Manoj Kumar
Chaudhuri, Mahua Ghosh
Sa, Biswanath
Das, Satadal
Dey, Rajib
Publication Title: 
Chemistry & Biodiversity

Nine phenolic compounds, including two phenolic carboxylic acids, 1 and 2, seven hydrolyzable tannins, 3-9, eight triterpenoids, including four oleanane-type triterpene acids, 10-13, and four of their glucosides, 14-17, isolated from a MeOH extract of the gall of Terminalia chebula Retz.

Author(s): 
Manosroi, Aranya
Jantrawut, Pensak
Ogihara, Eri
Yamamoto, Ayako
Fukatsu, Makoto
Yasukawa, Ken
Tokuda, Harukuni
Suzuki, Nobutaka
Manosroi, Jiradej
Akihisa, Toshihiro
Publication Title: 
PloS One

Inhibition of Acetylcholinesterase (AChE) is still considered as the main therapeutic strategy against Alzheimer's disease (AD). Many plant derived phytochemicals have shown AChE inhibitory activity in addition to the currently approved drugs for AD. In the present study, methanolic extracts of 20 plants used in Indian Ayurvedic system of medicine for improving cognitive function were screened for acetylcholinesterase inhibitory activity by Ellman's microplate colorimetric method.

Author(s): 
Mathew, Maya
Subramanian, Sarada
Publication Title: 
BioFactors (Oxford, England)

The thiazolidinedione (TZDs) class of drugs are very effective for the treatment of type 2 diabetes mellitus (T2DM). But due to the adverse effects of synthetic TZDs, their use is strictly regulated. The therapeutic actions of TZDs are mediated via modulation of peroxisome proliferator-activated receptor gamma (PPAR?). Naturally occurring PPAR? modulators are more desirable as they lack the serious adverse effects caused by TZDs. This has prompted the exploitation of medicinal plants used in traditional medicine, for their potential PPAR? activity.

Author(s): 
Shyni, Gangadharan Leela
Kavitha, Sasidharan
Indu, Sasidharan
Arya, Anil Das
Anusree, Sasidharan Suseela
Vineetha, Vadavanath Prabhakaran
Vandana, Sankar
Sundaresan, Andikannu
Raghu, Kozhiparambil Gopalan
Publication Title: 
Pharmaceutical Biology

CONTEXT: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. OBJECTIVE: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula.

Author(s): 
Reddy, Murali Mohan
Dhas Devavaram, Jackson
Dhas, Jebasingh
Adeghate, Ernest
Starling Emerald, Bright
Publication Title: 
Bollettino Chimico Farmaceutico

The effect of the methanolic extract of Newbouldia laevis seem on the central nervous system of rats and mice was investigated. The extract was tested on spontaneous motor activity, exploratory behaviour, apomorphine induced climbing behaviour in mice and pentobarbital induced hypnosis in rats. The extract caused considerable reductions of exploratory activity, spontaneous motor activity and prolonged pentobarbitone-induced hypnosis in rats. It was also found to attenuate apomorphine climbing in mice.

Author(s): 
Amos, S.
Binda, L.
Vongtau, H.
Chindo, B.
Abbah, J.
Sambo, N.
Odin, E. M.
Okwute, S. K.
Akah, P.
Wambebe, C.
Gamaniel, K.
Publication Title: 
Journal of Ethnopharmacology

The anxiolytic and sedative effects of Tilia americana L. var. mexicana (Schltdl.) Hardin inflorescence extracts and its acute toxicity were tested. Sodium pentobarbital (SP)-induced hypnosis potentiation (SPP), as well as ambulatory activity and anti-anxiety response in three different experimental models were evaluated with hexane and methanol extracts in mice.

Author(s): 
Aguirre-Hernández, E.
Martínez, A. L.
González-Trujano, M. E.
Moreno, J.
Vibrans, H.
Soto-Hernández, M.
Publication Title: 
Journal of Ethnopharmacology

Preliminary pharmacological studies were performed on the methanol extract of Bixa orellana L. (Bixaceae) leaves to investigate neuropharmacological, anticonvulsant, analgesic, antidiarrhoeal activity and effect on gastrointestinal motility. All studies were conducted in mice using doses of 125, 250 and 500 mg/kg of body weight. In the pentobarbitone-induced hypnosis test, the extract statistically reduced the time for the onset of sleep at 500 mg/kg dose and (dose-dependently) increased the total sleeping time at 250 and 500 mg/kg dose.

Author(s): 
Shilpi, Jamil Ahmad
Taufiq-Ur-Rahman, Md
Uddin, Shaikh Jamal
Alam, Md Shahanur
Sadhu, Samir Kumar
Seidel, Véronique
Publication Title: 
Pharmaceutical Biology

CONTEXT: Fruits of Ternstroemia sylvatica Schltdl. and Cham. (Theaceae) are used in Mexican traditional medicine to alleviate anxiety, sleep disorders and seizures; however, the active principles have not been identified. OBJECTIVE: To identify the neuroactive principles of T. sylvatica fruits using neuropharmacological tests on mice. MATERIALS AND METHODS: The methanol and aqueous extracts of pericarp or seeds of T. sylvatica fruits were intraperitoneally administered (1-562?mg/kg, single doses) to mice.

Author(s): 
Balderas-López, José Luis
Alfaro-Romero, Alejandro
Monroy, Amor
López-Villafranco, Ma Edith
Rivero-Cruz, José Fausto
Navarrete, Andrés
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Traditionally, the leaves of Abies pindrow Royle are employed as an ayurvedic remedy for fever, hypoglycaemic, respiratory and inflammatory conditions. In this study, dichloromethane, methanol and acetone extracts of A. pindrow leaves were analysed for their phytochemical content and in vitro antioxidant activities. The methanol extract exhibited highest antioxidant activity while acetone extract showed presence of relatively high total phenol and flavonoids contents.

Author(s): 
Gupta, D.
Bhardwaj, R.
Gupta, R. K.

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