Methicillin Resistance

Publication Title: 
Pharmacotherapy

Methicillin-resistant Staphylococcus aureus (MRSA) bacteria are a common cause of hospital- and community-acquired infections. Persons may have asymptomatic colonization with MRSA in the nares, axillae, perineum, or groin. Since MRSA colonization often precedes infection, and infection is associated with significant morbidity and mortality, there is great interest in preventing the transmission of MRSA and decolonizing persons who harbor these bacteria. We provide an evidence-based review of MRSA decolonization agents.

Author(s): 
McConeghy, Kevin W.
Mikolich, Dennis J.
LaPlante, Kerry L.
Publication Title: 
Biological & Pharmaceutical Bulletin

Examination of the EtOH extract of the fruiting bodies of Terminalia chebula RETZ. led to the isolation of two potent antimicrobial substances against even methicillin-resistant strains of Staphylococcus aureus. On the basis of spectroscopic evidence, the two isolates have been identified as gallic acid and its ethyl ester.

Author(s): 
Sato, Y.
Oketani, H.
Singyouchi, K.
Ohtsubo, T.
Kihara, M.
Shibata, H.
Higuti, T.
Publication Title: 
Journal of Basic Microbiology

Ethanolic extracts and some fractions from 10 Indian medicinal plants, known for antibacterial activity, were investigated for their ability to inhibit clinical isolates of beta-lactamase producing methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). Synergistic interaction of plant extracts with certain antibiotics was also evaluated. The MRSA test strains were found to be multi-drug resistant and also exhibited high level of resistance to common beta-lactam antibiotics.

Author(s): 
Aqil, Farrukh
Khan, M. Sajjad A.
Owais, Mohd
Ahmad, Iqbal
Publication Title: 
British Journal of Nursing (Mark Allen Publishing)

Aromatherapy is often misunderstood and consequently somewhat marginalized. Because of a basic misinterpretation, the integration of aromatherapy into UK hospitals is not moving forward as quickly as it might. Aromatherapy in UK is primarily aimed at enhancing patient care or improving patient satisfaction, and it is frequently mixed with massage.

Author(s): 
Buckle, Jane
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Because of its virulence and antibiotic resistance, Staphylococcus aureus is a more formidable pathogen now than at any time since the pre-antibiotic era. In an effort to identify and develop novel antimicrobial agents with activity against this pathogen, we have examined Gynoxys verrucosa Wedd (Asteraceae), an herb used in traditional medicine in southern Ecuador for the treatment and healing of wounds.

Author(s): 
Ordóñez, Paola E.
Quave, Cassandra L.
Reynolds, William F.
Varughese, Kottayil I.
Berry, Brian
Breen, Philip J.
Malagón, Omar
Smeltzer, Mark S.
Compadre, Cesar M.
Publication Title: 
Journal of Natural Products

Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 μg/mL against the fungal pathogen Candida albicans and 50 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA).

Author(s): 
Russell, Floyd
Harmody, Dedra
McCarthy, Peter J.
Pomponi, Shirley A.
Wright, Amy E.
Publication Title: 
Annals of Clinical Microbiology and Antimicrobials

BACKGROUND: The rise of antibiotic resistance among methicillin resistant Staphylococcus aureus (MRSA), have caused concerns for the treatment of MRSA infections. Hence, search for an alternative therapy for these infections is inevitable. Folk Indian medicine refers to the use of leaf and stem bark powder of Tabernaemontana alternifolia (Roxb) in treatment of skin infections, but no scientific report establishes its antibacterial activity. METHODS: Direct aqueous extracts and sequential aqueous extracts of the stem bark of T.

Author(s): 
Marathe, Nachiket P.
Rasane, Mandar H.
Kumar, Himanshu
Patwardhan, Ankur A.
Shouche, Yogesh S.
Diwanay, Sham S.
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