Methotrexate

Publication Title: 
Phytotherapy research: PTR

Triphala is categorized as a rejuvenator and antioxidant-rich Ayurvedic herbal formulation and has traditionally been used in various gastric problems including intestinal inflammation. The aim of the present study was to examine the comparative enteroprotective effect of Triphala formulations against methotrexate-induced intestinal damage in rats. Triphala formulations were prepared by mixing equal (1:1:1) and unequal (1:2:4) proportions of Terminalia chebula Retz., Terminalia belerica (Gaertn.) Roxb. and Emblica officinalis Gaertn.

Author(s): 
Nariya, Mukeshkumar
Shukla, Vinay
Jain, Sunita
Ravishankar, Basavaiah
Publication Title: 
Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health

INTRODUCTION: In the United States, ectopic pregnancies are relatively common and associated with significant maternal morbidity and mortality. The Ethical and Religious Directives for Catholic Health Care Services (the Directives) govern the provision of care in Catholic-affiliated hospitals and prohibit the provision of abortion in almost all circumstances.

Author(s): 
Foster, Angel M.
Dennis, Amanda
Smith, Fiona
Publication Title: 
Trends in Parasitology

The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. A possible approach to developing new antimalarials is to find new uses for old drugs. Some anticancer agents such as methotrexate and trimetrexate are active against malaria. However, they are commonly perceived to be toxic and thus not suitable for malaria treatment. In this opinion article, we examine how the toxicity of anticancer agents is just a matter of dose or 'only dose makes the poison', as coined in Paracelsus' law.

Author(s): 
Nzila, Alexis
Okombo, John
Becker, Ruy Perez
Chilengi, Roma
Lang, Trudie
Niehues, Tim
Publication Title: 
Indian Journal of Experimental Biology

Rotula aquatica was extensively used by vaidyas (Ayurvedic practioners) in holistic treatment of cancer. In the present study, an attempt has been made to evaluate the antimitotic activity of R. aquatica. Preliminary antimitotic screening was done using Allium cepa root tip assay. The mitotic index of the root tips markedly decreased with increasing concentration of the aqueous extract. The different fractions obtained by successive extraction of R. aquatica using solvents of increasing polarity were also evaluated for their antimitotic activity.

Author(s): 
Patil, S.
Narayanan, S.
Eibl, G.
Jolly, C. I.
Publication Title: 
Phytotherapy research: PTR

Triphala is categorized as a rejuvenator and antioxidant-rich Ayurvedic herbal formulation and has traditionally been used in various gastric problems including intestinal inflammation. The aim of the present study was to examine the comparative enteroprotective effect of Triphala formulations against methotrexate-induced intestinal damage in rats. Triphala formulations were prepared by mixing equal (1:1:1) and unequal (1:2:4) proportions of Terminalia chebula Retz., Terminalia belerica (Gaertn.) Roxb. and Emblica officinalis Gaertn.

Author(s): 
Nariya, Mukeshkumar
Shukla, Vinay
Jain, Sunita
Ravishankar, Basavaiah
Publication Title: 
Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases

OBJECTIVE: To compare classic Ayurveda, methotrexate (MTX), and their combination in a double-blind, randomized, double-dummy, pilot trial in rheumatoid arthritis (RA) for 36 weeks. METHODS: Forty-three seropositive RA patients by American College of Rheumatology (ACR) criteria with disease duration of less than 7 years were assigned to the following treatment groups: MTX plus Ayurvedic placebo (n = 14), Ayurveda plus MTX placebo (n = 12), or Ayurveda plus MTX (n = 17).

Author(s): 
Furst, Daniel E.
Venkatraman, Manorama M.
McGann, Mary
Manohar, P. Ram
Booth-Laforce, Cathryn
Sarin, Reshmi
Sekar, P. G.
Raveendran, K. G.
Mahapatra, Anita
Gopinath, Jidesh
Kumar, P. R. Krishna
Publication Title: 
Pharmaceutical Biology

CONTEXT: Withania somnifera (Linn.) Dunal (Solanaceae) has long been used as an herb in Ayurvedic and indigenous medicine and has received intense attention in recent years for its chemopreventive properties. OBJECTIVE: The present study focuses on the effect of W. somnifera root powder on the behavioral and radiological changes in collagen-induced arthritic rats. MATERIALS AND METHODS: The rats were randomly divided into five groups: normal control, arthritic control, arthritic rats treated with W.

Author(s): 
Gupta, Apurva
Singh, Surendra
Publication Title: 
Arthritis Research & Therapy

Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However, the mechanisms of action of these agents are not fully defined. Using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis, we determined whether the ethanol extract of Celastrus aculeatus Merr. (Celastrus), a Chinese herb, can down-modulate the severity of AA, and also examined the Celastrus-induced changes in immune responses to the disease-related antigen mycobacterial heat-shock protein 65 (Bhsp65).

Author(s): 
Tong, Li
Moudgil, Kamal D.
Publication Title: 
American Journal of Physical Medicine & Rehabilitation / Association of Academic Physiatrists

Eosinophilic fasciitis (EF), first described in 1974, is characterized by the sudden onset of painful swelling with induration of the soft tissues and peripheral eosinophilia, often after an episode of intense physical exertion. It rapidly progresses to joint contractures because of inflammation and fibrosis of the fascia. Of the 200 cases reported in the medical literature, most have responded positively to a prolonged course of oral prednisone. Although complete recovery is possible, more frequently signs and symptoms of EF persist.

Author(s): 
O'Laughlin, T. J.
Klima, R. R.
Kenney, D. E.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To analyze the indications of the therapies for rheumatoid arthritis (RA) with neural network model analysis. METHODS: Three hundred and ninety-seven patients were included in the clinical trial from 9 clinical centers. They were randomly divided into Western medicine (WM) treated group, 194 cases; and traditional Chinese herbal medicine (CM) treated group, 203 cases. A complete physical examination and 18 common clinical manifestations were prepared before the randomization and after the treatment.

Author(s): 
Zha, Qing-lin
He, Yi-Ting
Yan, Xiao-ping
Su, Li
Song, Yue-jin
Zeng, Sheng-ping
Liu, Wei
Feng, Xing-hua
Qian, Xian
Zhu, Wan-hua
Lin, Se-qi
Lu, Cheng
Lu, Ai-Ping

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