Methylenetetrahydrofolate Reductase (NADPH2)

Publication Title: 
Journal of Neurogenetics

Folate metabolism is essential for cellular functioning. Despite extensive research on the roles of folate-metabolism-related gene polymorphisms in the pathophysiology of many diseases, such as cardiovascular disease, cancers, and sudden sensorineural hearing loss, little is known about their association with MÈniËre's disease (MD). The aim of this study was to investigate the effect of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T and A1298C) on the risk of MD in a Japanese population.

Author(s): 
Huang, Yang
Teranishi, Masaaki
Uchida, Yasue
Nishio, Naoki
Kato, Ken
Otake, Hironao
Yoshida, Tadao
Sone, Michihiko
Sugiura, Saiko
Ando, Fujiko
Shimokata, Hiroshi
Nakashima, Tsutomu
Publication Title: 
International Journal of Geriatric Psychiatry

OBJECTIVE: Catechol-O-Methyltransferase (COMT) and Methylenetetrahydrofolate reductase (MTHFR) had been reported to relate to depression but with inconsistent results. The basal ganglia are also important in the pathophysiology of affective disorder via connections with limbic system and prefrontal cortex. The authors examined the relationship between an interaction of COMT/MTHFR polymorphisms and volumes of putamen in depressed and nondepressed elders. METHODS: Participants included 170 depressed and 83 nondepressed subjects aged 60 years or older.

Author(s): 
Pan, Chih-Chuan
McQuoid, Douglas R.
Taylor, Warren D.
Payne, Martha E.
Ashley-Koch, Allison
Steffens, David C.
Publication Title: 
Brain, Behavior, and Immunity

Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation.

Author(s): 
Peerbooms, Odette L. J.
van Os, Jim
Drukker, Marjan
Kenis, Gunter
Hoogveld, Loes
MTHFR in Psychiatry Group
De Hert, Marc
Delespaul, Philippe
van Winkel, Ruud
Rutten, Bart P. F.
Publication Title: 
PloS One

BACKGROUND: Responding to errors is a critical first step in learning from mistakes, a process that is abnormal in schizophrenia. To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients.

Author(s): 
Roffman, Joshua L.
Nitenson, Adam Z.
Agam, Yigal
Isom, Marlisa
Friedman, Jesse S.
Dyckman, Kara A.
Brohawn, David G.
Smoller, Jordan W.
Goff, Donald C.
Manoach, Dara S.
Publication Title: 
Epigenomics

We posit that maternal prenatal nutrition can influence offspring schizophrenia risk via epigenetic effects. In this article, we consider evidence that prenatal nutrition is linked to epigenetic outcomes in offspring and schizophrenia in offspring, and that schizophrenia is associated with epigenetic changes. We focus upon one-carbon metabolism as a mediator of the pathway between perturbed prenatal nutrition and the subsequent risk of schizophrenia.

Author(s): 
Kirkbride, James B.
Susser, Ezra
Kundakovic, Marija
Kresovich, Jacob K.
Davey Smith, George
Relton, Caroline L.
Publication Title: 
PloS One

Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR. For this study, we selected 69 case children born small-for-gestational age (SGA, birth weight <-2SDS) and 471 control children. Fetal growth was assessed with serial ultrasound measurements. Information on birth outcomes was retrieved from medical records.

Author(s): 
Bouwland-Both, Marieke I.
van Mil, Nina H.
Stolk, Lisette
Eilers, Paul H. C.
Verbiest, Michael M. P. J.
Heijmans, Bastiaan T.
Tiemeier, Henning
Hofman, Albert
Steegers, Eric A. P.
Jaddoe, Vincent W. V.
Steegers-Theunissen, Régine P. M.
Publication Title: 
Neuro Endocrinology Letters

OBJECTIVES: Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. METHODS: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR 677 CT+TT genotype was found (OR=1.6, p=0.021).

Author(s): 
Lochman, Jan
PlesnÌk, Ji?Ì
Janout, VladimÌr
Povov·, Jana
MÌöek, Ivan
Dvo?·kov·, Dagmar
äer˝, Omar
Publication Title: 
Reproduction (Cambridge, England)

Maternal one-carbon (1-C) metabolism provides methylgroups for fetal development and programing by DNA methylation as one of the underlying epigenetic mechanisms. We aimed to investigate maternal 1-C biomarkers, folic acid supplement use, and MTHFR C677T genotype as determinants of 1-C metabolism in early pregnancy in association with newborn DNA methylation levels of fetal growth and neurodevelopment candidate genes. The participants were 463 mother-child pairs of Dutch national origin from a large population-based birth cohort in Rotterdam, The Netherlands.

Author(s): 
van Mil, Nina H.
Bouwland-Both, Marieke I.
Stolk, Lisette
Verbiest, Michael M. P. J.
Hofman, Albert
Jaddoe, Vincent W. V.
Verhulst, Frank C.
Eilers, Paul H. C.
Uitterlinden, AndrÈ G.
Steegers, Eric A. P.
Tiemeier, Henning
Steegers-Theunissen, Régine P. M.
Publication Title: 
Progress in Biophysics and Molecular Biology

Epigenetic mechanisms are now recognized to play roles in disease etiology. Several diseases increasing in frequency are associated with altered DNA methylation. DNA methylation is accomplished through metabolism of methyl donors such as folate, vitamin B12, methionine, betaine (trimethylglycine), and choline. Increased intake of these compounds correlates with decreased neural tube defects, although this mechanism is not well understood.

Author(s): 
Shorter, Kimberly R.
Felder, Michael R.
Vrana, Paul B.
Publication Title: 
Cancer causes & control: CCC

OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR), which is expressed in the liver, may be involved in both DNA methylation and DNA synthesis. It is also indicated as a potential risk factor of liver cancer in patients with chronic liver disease. To date, no study has been conducted on MTHFR and hepatocellular carcinoma (HCC) using a population-based design. The objective of this study was to evaluate the effects of polymorphisms of the MTHFR gene on the risk of primary liver cancer and their possible effect modifications on various environmental risk factors.

Author(s): 
Mu, Li-Na
Cao, Wei
Zhang, Zuo-Feng
Cai, Lin
Jiang, Qing-Wu
You, Nai-Chieh
Goldstein, Binh Yang
Wei, Guo-Rong
Chen, Chuan-Wei
Lu, Qing-Yi
Zhou, Xue-Fu
Ding, Bao-Guo
Chang, Jun
Yu, Shun-Zhang

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