Publication Title: 
Antimicrobial Agents and Chemotherapy

The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry parameters.

Morris, Carrie A.
Pokorny, Rolf
Lopez-Lazaro, Luis
Miller, Robert M.
Arbe-Barnes, Sarah
Duparc, Stephan
Borghini-Fuhrer, Isabelle
Shin, Jang-Sik
Fleckenstein, Lawrence
Publication Title: 
Brain Research

Labetalol, a combined alpha1, beta1, and beta2 adrenoceptor-blocking drug, has been shown to have analgesic properties in vivo. To determine the underlying mechanisms, we examined its effects on GABAA receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous firings of rat ventrolateral periaqueductal gray (PAG) neurons, either mechanically dissociated, or in acute brain slices. These PAG neurons mediate opioid-mediated analgesia and pain transmission and are under tonic control of GABAergic interneurons.

Xiao, Cheng
Zhou, Chunyi
Atlas, Glen
Delphin, Ellise
Ye, Jiang Hong
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