The pharmacological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent, on the central nervous system were studied in various experimental animals as compared with those of disopyramide, mexiletine and lidocaine, and the following results were obtained. 1. Acute toxicity of SUN 1165 in mice was similar to that of mexiletine, and twice as potent as compared with that of disopyramide and lidocaine.
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine
PURPOSE: To observe the therapeutic effect of needling at Neiguan (PC 6) plus oral administration of mexiletine. METHODS: 60 cases of frequent ventricular extrasystole were randomly divided into two groups: a treatment group, and a control group. In the control group, mexiletine was orally administered, and in the treatment group needling at bilateral Neiguan (PC 6) plus oral administration of mexiletine were given. 2 weeks of treatments constituted a therapeutic course.