Mice, Inbred BALB C

Publication Title: 
Antiviral Research

Traditional herbal medicines have been safely used for the treatment of various human diseases since ancient China. We selected 10 herbal extracts with therapeutic antiherpes simplex virus type 1 (HSV-1) activity. Among these, Geum japonicum Thunb., Rhus javanica L., Syzygium aromaticum (L.) Merr. et Perry, or Terminalia chebula Retzus showed a stronger anti-HSV-1 activity in combination with acyclovir than the other herbal extracts in vitro.

Author(s): 
Kurokawa, M.
Nagasaka, K.
Hirabayashi, T.
Uyama, S.
Sato, H.
Kageyama, T.
Kadota, S.
Ohyama, H.
Hozumi, T.
Namba, T.
Publication Title: 
International Journal of Tissue Reactions

Allergic rhinitis is an immunological disorder and an inflammatory response of nasal mucosal membranes. Allergic rhinitis, a state of hypersensitivity, occurs when the body overreacts to a substance such as pollens or dust. A novel, safe polyherbal formulation (Aller-7/NR-A2) has been developed for the treatment of allergic rhinitis using a unique combination of extracts from seven medicinal plants including Phyllanthus emblica, Terminalia chebula, Terminalia bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale and Piper longum.

Author(s): 
Pratibha, N.
Saxena, V. S.
Amit, A.
D'Souza, P.
Bagchi, M.
Bagchi, D.
Publication Title: 
Pharmaceutical Biology

Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800?mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats.

Author(s): 
Sheng, Zunlai
Yan, Xin
Zhang, Ruili
Ni, Huilin
Cui, Yuanxu
Ge, Junwei
Shan, Anshan
Publication Title: 
Oncology Reports

Silent information regulator 2 (SIR2) is a highly conserved protein, the mammalian orthologue of which, SIRT1, exhibits histone deacetylase activity. SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration. However, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors suppress the growth of tumor cells. The relationship between SIRT1 and metastasis remains to be clarified.

Author(s): 
Suzuki, Kensuke
Hayashi, Ryuji
Ichikawa, Tomomi
Imanishi, Shingo
Yamada, Toru
Inomata, Minehiko
Miwa, Toshiro
Matsui, Shoko
Usui, Isao
Urakaze, Masaharu
Matsuya, Yuji
Ogawa, Hirofumi
Sakurai, Hiroaki
Saiki, Ikuo
Tobe, Kazuyuki
Publication Title: 
Biological & Pharmaceutical Bulletin

Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We now showed that this combination also proved to be adequate in combating the formation of hyphae in vitro.

Author(s): 
Chang, Wenqiang
Li, Ying
Zhang, Li
Cheng, Aixia
Liu, Yongqing
Lou, Hongxiang
Publication Title: 
Basic & Clinical Pharmacology & Toxicology

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively.

Author(s): 
Kim, Byung J.
Nam, Joo H.
Kwon, Young K.
So, Insuk
Kim, Seon J.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Tumors use a wide array of immunosuppressive strategies, such as reducing the longevity and survival of dendritic cells (DCs), to diminish immune responses and limit the effect of immunotherapy. In this study, we found that tumors upregulate the expression of multiple microRNAs (miRNAs), such as miR-16-1, miR-22, miR-155, and miR-503. These tumor-associated miRNAs influenced the survival and longevity of DCs by affecting the expression of multiple molecules that are associated with apoptotic signaling pathways.

Author(s): 
Min, Siping
Liang, Xue
Zhang, Miaomiao
Zhang, Yuan
Mei, Shiyue
Liu, Jinzhe
Liu, Jingyi
Su, Xiaomin
Cao, Shuisong
Zhong, Xueqing
Li, Yueming
Sun, Jiatan
Liu, Qiaofei
Jiang, Xingran
Che, Yongzhe
Yang, Rongcun
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Xenobiotic metabolism has been proposed to play a role in modulating the rate of aging. Xenobiotic metabolizing enzymes (XME) are expressed at higher levels in calorically restricted mice (CR) and in GH/IGF-I-deficient, long-lived mutant mice. In this study, we show that many phase I XME genes are similarly upregulated in additional long-lived mouse models, including "crowded litter" (CL) mice, whose lifespan has been increased by food restriction limited to the first 3 wk of life, and in mice treated with rapamycin.

Author(s): 
Steinbaugh, Michael J.
Sun, Liou Y.
Bartke, Andrzej
Miller, Richard A.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Early-life adversity increases the risk for psychopathology in later life. The underlying mechanism(s) is unknown, but epigenetic variation represents a plausible candidate. Early-life exposures can disrupt epigenetic programming in the brain, with lasting consequences for gene expression and behavior. This evidence is primarily derived from animal studies, with limited study in humans due to inaccessibility of the target brain tissue.

Author(s): 
Kundakovic, Marija
Gudsnuk, Kathryn
Herbstman, Julie B.
Tang, Deliang
Perera, Frederica P.
Champagne, Frances A.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Within one day after a single IP injection of cedar sesquiterpenes into mice, pentobarbital sleeptime was reduced by 40%. The estimated ED50 is 50 mg terpenes/kg body weight. The mice recovered from this terpene-induced reduction in the strength of hypnosis within 6 days after the terpene injection. The potency of the terpenes, the rapidity of their action, and the duration of their effectiveness in modulating a drug response suggest their usefulness as a pharmacological tool.

Author(s): 
Malkinson, A. M.
Shere, W. C.

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