Mice, Inbred ICR

Publication Title: 
Antiviral Research

Hot water extracts of four traditional herbs, Geum japonicum, Syzygium aromaticum, Terminalia chebula and Rhus javanica, which have been shown to have anti-herpes simplex virus (HSV) activity in vivo, were examined for anti-cytomegalovirus (CMV) activity in vitro and in vivo in this study. They inhibited replication of human CMV and murine CMV (MCMV) in vitro. These anti-CMV activities in vivo were examined in an MCMV infection model using immunosuppressed mice.

Author(s): 
Yukawa, T. A.
Kurokawa, M.
Sato, H.
Yoshida, Y.
Kageyama, S.
Hasegawa, T.
Namba, T.
Imakita, M.
Hozumi, T.
Shiraki, K.
Publication Title: 
Journal of Ethnopharmacology

We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg).

Author(s): 
Shin, T. Y.
Jeong, H. J.
Kim, D. K.
Kim, S. H.
Lee, J. K.
Kim, D. K.
Chae, B. S.
Kim, J. H.
Kang, H. W.
Lee, C. M.
Lee, K. C.
Park, S. T.
Lee, E. J.
Lim, J. P.
Kim, H. M.
Lee, Y. M.
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

OBJECTIVE: To evaluate the in vitro and in vivo antiplasmodial activity and the cytotoxicity of Phyllanthus emblica Linn, Terminalia chebula Retz, and Terminalia bellerica (Gaertn) Roxb extracts. MATERIAL AND METHOD: Standard phytochemical screening tests were used to detect metabolites in the plant extract. The water extracts of medicinal plants were tested for their antiplasmodial activity in vitro by assessing their ability to inhibit the uptake of [3H] hypoxanthine into the Plasmodium falciparum K1 multidrug-resistant strain.

Author(s): 
Pinmai, Khosit
Hiriote, Wanwarang
Soonthornchareonnon, Noppamas
Jongsakul, Krisada
Sireeratawong, Seewaboon
Tor-Udom, Siripen
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is composed of equal proportions of the three fruits including Terminalia chebula Retz., Terminalia sp. and Terminalia bellirica Roxb. In Southeast Asia, these fruits are used as both food and medicine. In Thai traditional medicine, Tri-sa-maw recipe is well known for treating fever, expectorant, periodic maintenance, and tight stomach relief OBJECTIVE: To study anti-inflammatory, analgesic and antipyretic activities of Tri-sa-maw recipe in experimental animals.

Author(s): 
Nanna, Urarat
Jaijoy, Kanjana
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Pharmaceutical Biology

CONTEXT: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. OBJECTIVE: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. MATERIALS AND METHODS: The viability of human skin fibroblasts after incubation with T.

Author(s): 
Yakaew, Swanya
Itsarasook, Khwunjit
Ngoenkam, Jatuporn
Jessadayannamaetha, Arum
Viyoch, Jarupa
Ungsurungsie, Malyn
Publication Title: 
Mechanisms of Ageing and Development

SL-diet was prepared using commercial pellets supplemented with 1% pulverized Streptococcus lactis (SL). SL fed group of ICR strain mice were bred from 8 weeks up to 75 weeks. End-point age for survival in these mice was approximately 75 weeks. No significant differences in survival rate were observed at 75 weeks between the commercial diet and SL-diet group. The superoxide dismutase (SOD) activities in the liver, brain and erythrocytes of 75-week-old mice significantly decreased compared with those aged 10 weeks.

Author(s): 
Abe, N.
Katsukura, Y.
Ohwada, S.
Watabe, N.
Ochi, H.
Kuboyama, M.
Publication Title: 
Arzneimittel-Forschung

A series of newly synthesized N-phenyl-substituted derivatives of succinimide were screened for anticonvulsant activity. Addition of a sulfonamide group in the p-position was of great consequence for the anticonvulsant effect. Substitution of a halogen in the m- or o-position improved activity against electroshock induced seizures. Pentylenetetrazole convulsions could only be prevented by few of these substances in smaller than 200 mg/kg oral doses. Activity could be further enhanced by adding more aliphatic or aromatic groups to the succinimide ring.

Author(s): 
Waser, P. G.
Ganz, A. J.
Pfirrmann, R. W.
Publication Title: 
General Pharmacology
Author(s): 
Hatoum, N. S.
Davis, W. M.
Elsohly, M. A.
Turner, C. E.
Publication Title: 
General Pharmacology

1. Pretreatment with a Cannabis constituent, cannabichromene (CBC), i.p., had no effect on in vitro hepatic microsomal enzyme activity compared to a known inhibitor of these systems, SKF 525-A. 2. The results indicate that the previously reported CBC potentiation of CNS depressant-induced hypnosis is not mediated by the hepatic microsomal enzyme system.

Author(s): 
Kapeghian, J. C.
Jones, A. B.
Murphy, J. C.
Elsohly, M. A.
Turner, C. E.
Publication Title: 
Psychopharmacology

We investigated how repeated agonistic confrontations affect the hypnotic effect of pentobarbital (PB) in male mice, using a resident-intruder paradigm. PB concentrations in the cortex, midbrain and brainstem were determined. Agonistic confrontations were terminated after 10 or 20 attack bites, and were repeated for 5 consecutive days. Immediately after the last encounter, PB (55 mg/kg, IP) was administered to both resident and intruder mice.

Author(s): 
Ohdo, S.
Yoshimura, H.
Ogawa, N.

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