Mice, Obese

Publication Title: 
Aging

SIRT1 is a NAD+-dependent deacetylase implicated in longevity and diverse physiological processes. SIRT1, as a key mediator of beneficial effects of caloric restriction, regulates lipid and glucose metabolism by deacetylating metabolic regulators, as well as histones, in response to nutritional deprivation.

Author(s): 
Lee, Jiyoung
Kemper, Jongsook Kim
Publication Title: 
Journal of Natural Medicines

In Ayurvedic medicine, Salacia reticulata is known to be useful against various metabolic diseases, including diabetes and obesity. In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months.

Author(s): 
Shimada, Tsutomu
Nagai, Eiichi
Harasawa, Yukiko
Akase, Tomoko
Aburada, Takashi
Iizuka, Seiichi
Miyamoto, Ken-ichi
Aburada, Masaki
Publication Title: 
Diabetes

We evaluated antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates. Animals received daily intraperitoneal injections of Panax ginseng berry extract for 12 days. On day 12, 150 mg/kg extract-treated ob/ob mice became normoglycemic (137 +/- 6.7 mg/dl) and had significantly improved glucose tolerance. The overall glucose excursion during the 2-h intraperitoneal glucose tolerance test decreased by 46% (P < 0.01) compared with vehicle-treated ob/ob mice.

Author(s): 
Attele, Anoja S.
Zhou, Yun-Ping
Xie, Jing-Tian
Wu, Ji An
Zhang, Liu
Dey, Lucy
Pugh, William
Rue, Paul A.
Polonsky, Kenneth S.
Yuan, Chun-Su
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Recent work shows that S-adenosylmethionine (AdoMet) helps maintain normal liver function as chronic hepatic deficiency results in spontaneous development of steatohepatitis and hepatocellular carcinoma. The mechanisms by which these nontraditional functions of AdoMet occur are unknown. Here, we use knockout mice deficient in hepatic AdoMet synthesis (MAT1A(-/-)) to study the proteome of the liver during the development of steatohepatitis.

Author(s): 
Santamaría, Enrique
Avila, Matías A.
Latasa, M. Ujue
Rubio, Angel
Martín-Duce, Antonio
Lu, Shelly C.
Mato, José M.
Corrales, Fernando J.
Publication Title: 
Acta Pharmacologica Sinica

AIM: The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were evaluated in diabetic C57BL/6J ob/ob mice. METHODS: Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg) or oral administration (150 and 300 mg/kg) for 12 d. Fasting blood glucose levels and body weight were measured after fasting the animals for 4 h. Peripheral glucose use was also measured using an intraperitoneal glucose tolerance test.

Author(s): 
Xie, Jing-Tian
Wang, Chong-Zhi
Wang, An-bao
Wu, Jian
Basila, Daniel
Yuan, Chun-Su
Publication Title: 
Free Radical Biology & Medicine

Obesity has been implicated in several diseases, including cancer; however, the relationship of obesity and susceptibility to ultraviolet (UV) radiation-caused skin diseases has not been investigated. As UV-induced oxidative stress has been implicated in several skin diseases, we assessed the role of obesity on UVB-induced oxidative stress in genetically obese Lep(ob)/Lep(ob) (leptin-deficient) mice.

Author(s): 
Katiyar, Santosh K.
Meeran, Syed M.
Publication Title: 
Journal of Food Science

Diabetes is a serious chronic metabolic disease and has a significant impact on patients' lives and the health care system. We previously observed that the organic solvent extract of American ginseng berry possessed significant antidiabetic effects in obese diabetic ob/ob mice after intraperitoneal injection. If American ginseng berry is useful as a dietary supplement, simple preparation and oral intake would be a convenient, safe, and practical means for consumers.

Author(s): 
Xie, J. T.
Wang, C. Z.
Ni, M.
Wu, J. A.
Mehendale, S. R.
Aung, H. H.
Foo, A.
Yuan, C. S.
Publication Title: 
The Journal of Nutrition

The incidence of nonalcoholic fatty liver disease (NAFLD) has risen along with the ongoing obesity epidemic. Green tea extract (GTE) inhibits intestinal lipid absorption and may regulate hepatic lipid accumulation. The objective of this study was to determine whether GTE protects against hepatic lipid accumulation during the development of NAFLD in an obese mouse model. Five-wk-old ob/ob (obese) mice and their lean littermates (8 mice x genotype(-1) x dietary treatment(-1)) were fed GTE at 0, 1, or 2% (wt:wt) for 6 wk.

Author(s): 
Bruno, Richard S.
Dugan, Christine E.
Smyth, Joan A.
DiNatale, Dana A.
Koo, Sung I.
Publication Title: 
Diabetes

OBJECTIVE: We sought to determine whether exosome-like vesicles (ELVs) released from adipose tissue play a role in activation of macrophages and subsequent development of insulin resistance in a mouse model. RESEARCH DESIGN AND METHODS: ELVs released from adipose tissue were purified by sucrose gradient centrifugation and labeled with green fluorescent dye and then intravenously injected into B6 ob/ob mice (obese model) or B6 mice fed a high-fat diet.

Author(s): 
Deng, Zhong-Bin
Poliakov, Anton
Hardy, Robert W.
Clements, Ronald
Liu, Cunren
Liu, Yuelong
Wang, Jianhua
Xiang, Xiaoyu
Zhang, Shuangqin
Zhuang, Xiaoying
Shah, Spandan V.
Sun, Dongmei
Michalek, Sue
Grizzle, William E.
Garvey, Timothy
Mobley, Jim
Zhang, Huang-Ge
Publication Title: 
Hepatology (Baltimore, Md.)

Chronic inflammation plays a critical role in promoting obesity-related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation. We found that the accumulation of immature myeloid cells, i.e., CD11b(+)Ly6C(hi)Ly6G(-) cells, in the liver of B6 mice fed a high-fat diet contribute to liver inflammation.

Author(s): 
Deng, Zhong-Bin
Liu, Yuelong
Liu, Cunren
Xiang, Xiaoyu
Wang, Jianhua
Cheng, Ziqiang
Shah, Spandan V.
Zhang, Shuangyin
Zhang, Liming
Zhuang, Xiaoying
Michalek, Sue
Grizzle, William E.
Zhang, Huang-Ge

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