Microscopy, Video

Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Flavonoids within Scutellaria baicalensis may be potent antioxidants on the basis of our studies of S. baicalensis extract. To further this work, we studied the antioxidative effects of baicalein, a flavonoid component of S. baicalensis, in a chick cardiomyocyte model of reactive oxygen species (ROS) generation during hypoxia, simulated ischemia-reperfusion, or mitochondrial complex III inhibition with antimycin A. Oxidant stress was measured by oxidation of the intracellular probes 2',7'-dichlorofluorescin diacetate and dihydroethidium.

Author(s): 
Shao, Zuo-Hui
Vanden Hoek, Terry L.
Qin, Yimin
Becker, Lance B.
Schumacker, Paul T.
Li, Chang-Qing
Dey, Lucy
Barth, Eugene
Halpern, Howard
Rosen, Gerald M.
Yuan, Chun-Su
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