Microvessels

Publication Title: 
Journal of Endodontics

INTRODUCTION: Dental pulp stem cells (DPSCs) have received much attention as a promising population of stem cells in regenerative endodontics. Securing a good blood supply during regeneration is a challenging task because of the constricted apical canal opening, which allows only a limited blood supply. The aim of this study was to investigate any potential synergistic effects of dental pulp stem cells and endothelial cells (ECs) on osteo-/odontogenic and angiogenic differentiation in vitro.

Author(s): 
Dissanayaka, Waruna Lakmal
Zhan, Xuan
Zhang, Chengfei
Hargreaves, Kenneth M.
Jin, Lijian
Tong, Edith H. Y.
Publication Title: 
Life Sciences

AIM: To investigate the association between vasculopathy and survival during experimental cerebral malaria (ECM), and to determine whether targeting the endothelin-1 (ET-1) pathway alone or in combination with the anti-malaria drug artemether (a semi-synthetic derivative of artemisinin) will improve microvascular hemorrhage and survival. MAIN METHODS: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) were randomly assigned to four groups: no treatment, artemether treated, ET(A) receptor antagonist (HJP-272) treated, or HJP-272 and artemether treated.

Author(s): 
Dai, Minxian
Freeman, Brandi
Bruno, Fernando P.
Shikani, Henry J.
Tanowitz, Herbert B.
Weiss, Louis M.
Reznik, Sandra E.
Stephani, Ralph A.
Desruisseaux, Mahalia S.
Publication Title: 
Vascular Medicine (London, England)

We previously reported an attenuation of both exercise hyperemia and measures of aerobic capacity in hypercholesterolemic mice. In this study, we expanded upon the previous findings by examining the temporal and quantitative relationship of hypercholesterolemia to aerobic and anaerobic capacity and by exploring several potential mechanisms of dysfunction. Eight-week-old wild type (n = 123) and apoE knockout (n = 79) C57BL/6J mice were divided into groups with distinct cholesterol levels by feeding with regular or high-fat diets. At various ages, the mice underwent treadmill ergospirometry.

Author(s): 
Maxwell, Andrew J.
Niebauer, Josef
Lin, Patrick S.
Tsao, Philip S.
Bernstein, Daniel
Cooke, John P.
Publication Title: 
Free Radical Biology & Medicine

Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A. Monolayer cultures of microvascular endothelial cells were incubated with ascorbate, dehydroascorbic acid (DHAA), the NADPH oxidase inhibitors apocynin and diphenyliodonium, or the PP2A inhibitor okadaic acid and then were exposed to septic insult (lipopolysaccharide and interferon-gamma).

Author(s): 
Han, Min
Pendem, Suresh
Teh, Suet Ling
Sukumaran, Dinesh K.
Wu, Feng
Wilson, John X.
Publication Title: 
Metabolism: Clinical and Experimental

Type 1 diabetes mellitus (T1DM) is associated with increased microvascular complications and is a proinflammatory state. The toll-like receptors (TLRs) are pattern recognition receptors on monocytes and important in atherosclerosis. We have shown increased TLR2 and TLR4 expression on monocytes of T1DM compared with controls. In this report, we tested the surface expression of TLR2 and TLR4 on monocytes of T1DM patients with microvascular complications (T1DM-MV) compared with those without (T1DM) and healthy controls. The study was performed at the University of California Davis.

Author(s): 
Devaraj, Sridevi
Jialal, Ishwarlal
Yun, Jung-Mi
Bremer, Andrew
Publication Title: 
American Journal of Clinical Pathology

Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte toll-like receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed.

Author(s): 
Devaraj, Sridevi
Yun, Jung-Mi
Duncan-Staley, Catherine R.
Jialal, Ishwarlal
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging.

Author(s): 
Ungvari, Zoltan
Csiszar, Anna
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Age-related impairment of angiogenesis is likely to play a central role in cerebromicrovascular rarefaction and development of vascular cognitive impairment, but the underlying mechanisms remain elusive. To test the hypothesis that dysregulation of Dicer1 (ribonuclease III, a key enzyme of the microRNA [miRNA] machinery) impairs endothelial angiogenic capacity in aging, primary cerebromicrovascular endothelial cells (CMVECs) were isolated from young (3 months old) and aged (24 months old) Fischer 344 × Brown Norway rats.

Author(s): 
Ungvari, Zoltan
Tucsek, Zsuzsanna
Sosnowska, Danuta
Toth, Peter
Gautam, Tripti
Podlutsky, Andrej
Csiszar, Agnes
Losonczy, Gyorgy
Valcarcel-Ares, M. Noa
Sonntag, William E.
Csiszar, Anna
Publication Title: 
Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism

Hypertension in the elderly substantially contributes to cerebromicrovascular damage and promotes the development of vascular cognitive impairment. Despite the importance of the myogenic mechanism in cerebromicrovascular protection, it is not well understood how aging affects the functional adaptation of cerebral arteries to high blood pressure. Hypertension was induced in young (3 months) and aged (24 months) C57/BL6 mice by chronic infusion of angiotensin II (AngII).

Author(s): 
Toth, Peter
Tucsek, Zsuzsanna
Sosnowska, Danuta
Gautam, Tripti
Mitschelen, Matthew
Tarantini, Stefano
Deak, Ferenc
Koller, Akos
Sonntag, William E.
Csiszar, Anna
Ungvari, Zoltan
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into various Traditional Chinese Medicine (TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu (LI 4), adding other acupoints based on syndrome.

Author(s): 
Huang, Tao
Yang, Lijian
Jia, Shuyong
Mu, Xiang
Wu, Mozheng
Ye, Hang
Liu, Weizhe
Cheng, Xinnong

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