Mild Cognitive Impairment

Publication Title: 
Brain, Behavior, and Immunity

Physical activity (PA) is emerging as a safe and effective tool in the prevention and treatment of psychiatric disorders. PA subtypes include aerobic, resistance, flexibility, neuromotor (involving balance, agility and co-ordination), mind-body (e.g. tai chi, qi gong and yoga) and mixed type trainings. Evidence from clinical trials suggests that PA subtypes can have positive clinical effects, however the effects on the symptomatology may vary according to the PA subtype.

Author(s): 
Eyre, Harris A.
Baune, Bernhard T.
Publication Title: 
Therapeutic Advances in Chronic Disease

Dementia is a common and debilitating syndrome with enormous impact on individuals and societies. Preventing disease onset or progression would translate to public health and societal benefits. In this review, we discuss the latest evidence on interventions that may show promise for the prevention of cognitive decline. We appraise existing evidence primarily drawn from randomized controlled trials, systematic reviews, and meta-analyses, but also highlight observational studies in humans and relevant work in model organisms.

Author(s): 
Rakesh, Gopalkumar
Szabo, Steven T.
Alexopoulos, George S.
Zannas, Anthony S.
Publication Title: 
Brain, Behavior, and Immunity

Physical activity (PA) is emerging as a safe and effective tool in the prevention and treatment of psychiatric disorders. PA subtypes include aerobic, resistance, flexibility, neuromotor (involving balance, agility and co-ordination), mind-body (e.g. tai chi, qi gong and yoga) and mixed type trainings. Evidence from clinical trials suggests that PA subtypes can have positive clinical effects, however the effects on the symptomatology may vary according to the PA subtype.

Author(s): 
Eyre, Harris A.
Baune, Bernhard T.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri has a long history in Ayurvedic medicine for neurological and behavioral defects. To assess its efficacy in improving cognitive function. MATERIALS AND METHODS: MEDLINE, EMBASE, CINAHL, AMED, Cochrane Central of clinical trial, WHO registry, Thai Medical Index, Index Medicus Siriraj library and www.clinicaltrial.gov were searched from the inception date of each database to June 2013 using scientific and common synonyms of Bacopa monnieri, cognitive performance or memory.

Author(s): 
Kongkeaw, Chuenjid
Dilokthornsakul, Piyameth
Thanarangsarit, Phurit
Limpeanchob, Nanteetip
Norman Scholfield, C.
Publication Title: 
Nature

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons. REST is lost, however, in mild cognitive impairment and Alzheimer's disease.

Author(s): 
Lu, Tao
Aron, Liviu
Zullo, Joseph
Pan, Ying
Kim, Haeyoung
Chen, Yiwen
Yang, Tun-Hsiang
Kim, Hyun-Min
Drake, Derek
Liu, X. Shirley
Bennett, David A.
Colai·covo, Monica P.
Yankner, Bruce A.
Publication Title: 
Epigenomics

Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

Author(s): 
Chouliaras, Leonidas
Kenis, Gunter
Visser, Pieter Jelle
Scheltens, Philip
Tsolaki, Magda
Jones, Roy W.
Kehoe, Patrick G.
Graff, Caroline
Girtler, Nicola G.
Wallin, ≈sa K.
Rikkert, Marcel Olde
Spiru, Luiza
Elias-Sonnenschein, Lyzel S.
Ramakers, Inez H. G. B.
Pishva, Ehsan
van Os, Jim
Steinbusch, Harry W. M.
Verhey, Frans R. J.
van den Hove, Daniel L. A.
Rutten, Bart P. F.
Publication Title: 
Current Alzheimer Research

Midlife habits may be important for the later development of Alzheimer's disease (AD). We estimated the contribution of midlife prayer to the development of cognitive decline. In a door-to-door survey, residents aged ≥65 years were systematically evaluated in Arabic including medical history, neurological, cognitive examination, and a midlife leisure-activities questionnaire. Praying was assessed by the number of monthly praying hours at midlife.

Author(s): 
Inzelberg, Rivka
Afgin, Anne E.
Massarwa, Magda
Schechtman, Edna
Israeli-Korn, Simon D.
Strugatsky, Rosa
Abuful, Amin
Kravitz, Efrat
Farrer, Lindsay A.
Friedland, Robert P.
Publication Title: 
Neurology

OBJECTIVE: To determine the time of acceleration in white matter hyperintensity (WMH) burden, a common indicator of cerebrovascular pathology, in relation to conversion to mild cognitive impairment (MCI) in the elderly. METHODS: A total of 181 cognitively intact elderly volunteers from the longitudinal, prospective, Oregon Brain Aging Study underwent yearly evaluations, including brain MRI, and cognitive testing. MRIs were analyzed for imaging markers of neurodegeneration: WMH and ventricular CSF (vCSF) volumes.

Author(s): 
Silbert, Lisa C.
Dodge, Hiroko H.
Perkins, Louie G.
Sherbakov, Lena
Lahna, David
Erten-Lyons, Deniz
Woltjer, Randall
Shinto, Lynne
Kaye, Jeffrey A.
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVES: To determine whether psychological well-being in people with mild cognitive impairment (MCI), a risk state for Alzheimer disease (AD), is associated with in vivo measures of brain pathology. METHODS: Cross-sectional clinical assessments and positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles, were performed on middle-aged and older adults at a university research institute.

Author(s): 
Chen, Stephen T.
Siddarth, Prabha
Saito, Nathan Y.
Rueda, Flori
Haight, Taylor
Ercoli, Linda M.
Miller, Karen J.
Lavretsky, Helen
Barrio, Jorge R.
Bookheimer, Susan Y.
Small, Gary W.
Merrill, David A.
Publication Title: 
Annals of Neurology

OBJECTIVE: This study examined amyloid-β (Aβ) deposition in 190 nondemented subjects aged ≥82 years to determine the proportion of Aβ-positive scans and associations with cognition, apolipoprotein E (APOE) status, brain volume, and Ginkgo biloba (Gb) treatment. METHODS: Subjects who agreed to participate had a brain magnetic resonance imaging and positron emission tomography scan with (11) C-labeled Pittsburgh compound B (PiB) following completion of a Gb treatment clinical trial.

Author(s): 
Mathis, Chester A.
Kuller, Lewis H.
Klunk, William E.
Snitz, Beth E.
Price, Julie C.
Weissfeld, Lisa A.
Rosario, Bedda L.
Lopresti, Brian J.
Saxton, Judith A.
Aizenstein, Howard J.
McDade, Eric M.
Kamboh, M. Ilyas
DeKosky, Steven T.
Lopez, Oscar L.

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