Mitochondria, Muscle

Publication Title: 
Comprehensive Physiology

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow capacity to the legs of patients. PAD leads to exercise intolerance that can progress in severity to greatly limit mobility, and in advanced cases leads to frank ischemia with pain at rest. It is estimated that 12 to 15 million people in the United States are diagnosed with PAD, with a much larger population that is undiagnosed. The presence of PAD predicts a 50% to 1500% increase in morbidity and mortality, depending on severity.

Haas, Tara L.
Lloyd, Pamela G.
Yang, Hsiao-Tung
Terjung, Ronald L.
Publication Title: 

Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers.

Lagouge, Marie
Argmann, Carmen
Gerhart-Hines, Zachary
Meziane, Hamid
Lerin, Carles
Daussin, Frederic
Messadeq, Nadia
Milne, Jill
Lambert, Philip
Elliott, Peter
Geny, Bernard
Laakso, Markku
Puigserver, Pere
Auwerx, Johan
Publication Title: 
Pfl¸gers Archiv: European Journal of Physiology

Average human life expectancy has progressively increased over many decades largely due to improvements in nutrition, vaccination, antimicrobial agents, and effective treatment/prevention of cardiovascular disease, cancer, etc. Maximal life span, in contrast, has changed very little. Caloric restriction (CR) increases maximal life span in many species, in concert with improvements in mitochondrial function. These effects have yet to be demonstrated in humans, and the duration and level of CR required to extend life span in animals is not realistic in humans.

Lanza, Ian R.
Nair, K. Sreekumaran
Publication Title: 
Experimental Gerontology

Aging is associated with a loss in muscle known as sarcopenia that is partially attributed to apoptosis. In aging rodents, caloric restriction (CR) increases health and longevity by improving mitochondrial function and the polyphenol resveratrol (RSV) has been reported to have similar benefits.

Joseph, Anna-Maria
Malamo, Angelina G.
Silvestre, Jason
Wawrzyniak, Nick
Carey-Love, Sean
Nguyen, Linda M.-D.
Dutta, Debapriya
Xu, Jinze
Leeuwenburgh, Christiaan
Adhihetty, Peter J.
Publication Title: 

OBJECTIVE: We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat diet. RESEARCH DESIGN AND METHODS: In dietary-obese C57BL/6J mice, sodium butyrate was administrated through diet supplementation at 5% wt/wt in the high-fat diet. Insulin sensitivity was examined with insulin tolerance testing and homeostasis model assessment for insulin resistance. Energy metabolism was monitored in a metabolic chamber.

Gao, Zhanguo
Yin, Jun
Zhang, Jin
Ward, Robert E.
Martin, Roy J.
Lefevre, Michael
Cefalu, William T.
Ye, Jianping
Publication Title: 
Obesity (Silver Spring, Md.)

OBJECTIVE: This study investigated the relationship between in vitro lipid content in myotubes and in vivo whole body phenotypes of the donors such as insulin sensitivity, intramyocellular lipids (IMCL), physical activity, and oxidative capacity. DESIGN AND METHODS: Six physically active donors were compared to six sedentary lean and six T2DM. Lipid content was measured in tissues and myotubes by immunohistochemistry. Ceramides, triacylglycerols, and diacylglycerols (DAGs) were measured by LC-MS-MS and GC-FID.

Bajpeyi, Sudip
Myrland, Cassandra K.
Covington, Jeffrey D.
Obanda, Diana
Cefalu, William T.
Smith, Steven R.
Rustan, Arild C.
Ravussin, Eric
Publication Title: 
Science Translational Medicine

Massage therapy is commonly used during physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. Although there is evidence that massage may relieve pain in injured muscle, how massage affects cellular function remains unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of 11 young male participants after exercise-induced muscle damage.

Crane, Justin D.
Ogborn, Daniel I.
Cupido, Colleen
Melov, Simon
Hubbard, Alan
Bourgeois, Jacqueline M.
Tarnopolsky, Mark A.
Publication Title: 
Biochemical and Biophysical Research Communications

In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12-months-old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA, or c9t11-CLA+t10c12-CLA (CLA-mix) for 6months. Both t10c12-CLA and CLA-mix groups showed significantly higher muscle mass, as compared to CO and c9t11-CLA groups, measured by dual-energy X-ray absorptiometry and muscle wet weight.

Rahman, M.
Halade, Ganesh V.
El Jamali, Amina
Fernandes, Gabriel
Publication Title: 
Free Radical Biology & Medicine

The purpose of this study was to understand the nature of the causes underlying the senescence-related decline in skeletal muscle mass and performance. Protein and lipid oxidative damage to upper hindlimb skeletal muscle mitochondria was compared between mice fed ad libitum and those restricted to 40% fewer calories--a regimen that increases life span by approximately 30-40% and attenuates the senescence-associated decrement in skeletal muscle mass and function.

Lass, A.
Sohal, B. H.
Weindruch, R.
Forster, M. J.
Sohal, R. S.
Publication Title: 
Science (New York, N.Y.)

The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were either completely or partially prevented by caloric restriction, the only intervention known to retard aging in mammals.

Lee, C. K.
Klopp, R. G.
Weindruch, R.
Prolla, T. A.


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