Models, Molecular

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Phenomena of long-term 'memory of water' imply that aqueous systems possessing it remain for a long period after the initial perturbation in an out-of equilibrium state without a constant supply of energy from the environment. It is argued here that various initial perturbations initiate development of a set of chain reactions of active oxygen species in water. Energy, in particular high grade energy of electronic excitation, released in such reactions can support non-equilibrium state of an aqueous system.

Voeikov, Vladimir L.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Homeopathic medicines are currently used in medical practice, despite controversy about their effectiveness. The preparation method is based on extremely high dilutions of many substances in water, far beyond any detectable level. For this reason, it has been suggested that water could retain a 'memory' of substances that have been dissolved in it before the successive dilutions. The paper stresses the fact that this idea is not compatible with our knowledge of pure water.

Teixeira, Jose
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

This paper discusses the nature of the active ingredient of homeopathic ultramolecular dilutions in terms of quantitative physics. First, the problem of the nature of an active ingredient in ultramolecular dilutions is analysed leading to the recognition of the necessity of characterizing the active ingredient as a non-local quality. Second, non-locality in quantum mechanics, which is used as a paradigm, is formally presented. Third, a generalization of quantum mechanics is considered, focussing on the consequences of weakening of the axioms.

Weingärtner, Otto
Publication Title: 
Biotechnology and Applied Biochemistry

Angiotensin-I-converting enzyme (ACE) plays an important role in blood pressure regulation. In this study, an ACE-hexapeptide inhibitor (Asp-Glu-Asn-Ser-Lys-Phe) designated as chebulin was produced from the fruit protein of Terminalia chebula Retz. by pepsin digestion, ultrafiltrated through a 3 KDa cut-off membrane, a reverse-phase high-performance liquid chromatography, and nano-liquid chromatography tandem mass spectrometry analysis. Chebulin was found to inhibit ACE in a noncompetitive manner, as supported by the structural model.

Sornwatana, Thakorn
Bangphoomi, Kunan
Roytrakul, Sittiruk
Wetprasit, Nuanchawee
Choowongkomon, Kiattawee
Ratanapo, Sunanta
Publication Title: 
Computational Biology and Chemistry

Drug resistant tuberculosis has threatened all the advances that have been made in TB control at the global stage in the last few decades. DNA gyrase enzymes are an excellent target for antibacterial drug discovery as they are involved in essential functions like DNA replication. Here we report, a successful application of high throughput virtual screening (HTVS) to identify an inhibitor of Mycobacterium DNA gyrase targeting the wild type and the most prevalent three double mutants of quinolone resistant DNA gyrase namely A90V+D94G, A74S+D94G and A90V+S91P.

Patel, Kunal
Tyagi, Chetna
Goyal, Sukriti
Jamal, Salma
Wahi, Divya
Jain, Ritu
Bharadvaja, Navneeta
Grover, Abhinav
Publication Title: 
Journal of Biomolecular Structure & Dynamics

The emergence of bacterial multidrug resistance is an increasing problem in treatment of infectious diseases. An important cause for the multidrug resistance of bacteria is the expression of multidrug efflux transporters. The multidrug and toxic compound extrusion (MATE) transporters are most recently recognized as unique efflux system for extrusion of antimicrobials and therapeutic drugs due to energy stored in either Na(+) or H(+) electrochemical gradient.

Kesherwani, Manish
Michael Gromiha, M.
Fukui, Kazuhiko
Velmurugan, Devadasan
Publication Title: 
FEBS letters

Strains of Caenorhabditis elegans mutant for clk-1 exhibit a 20-40% increase in mean lifespan. clk-1 encodes a mitochondrial protein thought to be either an enzyme or regulatory molecule acting within the ubiquinone biosynthesis pathway. Here CLK-1 is shown to be related to the ubiquinol oxidase, alternative oxidase, and belong to the functionally diverse di-iron-carboxylate protein family which includes bacterioferritin and methane mono-oxygenase.

Rea, S.
Publication Title: 
International Journal of Radiation Biology

PURPOSE: Telomeres are specialized DNA-protein complexes found at the ends of eukaryotic chromosomes. In normal somatic cells these become shorter with each cell division and appear to control their replicative lifespan. However almost all tumours show activation of the enzyme telomerase, a specialised reverse transcriptase/DNA polymerase, that can add new telomeric repeats to the ends of chromosomes and this appears to be a key factor in the cell immortalization process.

Laughton, C. A.
Grindon, C.
Girard, P.
Nikjoo, H.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Extracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits. METHODS: S. senanensis leaves were extracted with subcritical water. An active small-molecule was isolated using reversed-phase high-performance liquid chromatography (HPLC), and identified as 3,4-dihydroxybenzaldehyde (protocatechuic aldehyde or PA). The effects of PA on the activity of histone demethylase, the Drosophila melanogaster lifespan and gene expression in Drosophila S2 cells were investigated.

Nakagawa-Yagi, Yuzo
Sato, Yukiko
Matsumoto, Emi
Nakatsuka, Shin-Ichi
Sakaki, Tsuyoshi
Muramatsu, Yukiko
Hara, Takaaki
Aigaki, Toshiro
Publication Title: 
Neurobiology of Disease

An increasing body of evidence indicates a role for oligomers of the amyloid-? peptide (A?) in the neurotoxicity of this peptide and the pathology of Alzheimer's disease (AD). Several neurotoxic oligomeric forms of A? have been noted ranging from the larger Amyloid ?-Derived Diffusible Ligands (ADDLs) to smaller trimers and dimers of A?. More recently a dodecameric form of A? with a 56 kDa molecular weight, denoted A?*56, was shown to cause memory impairment in AD model mice.

Scherzer-Attali, R.
Farfara, D.
Cooper, I.
Levin, A.
Ben-Romano, T.
Trudler, D.
Vientrov, M.
Shaltiel-Karyo, R.
Shalev, D. E.
Segev-Amzaleg, N.
Gazit, E.
Segal, D.
Frenkel, D.


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