Momordica charantia

Publication Title: 
Nutrition Journal

BACKGROUND: Although beneficial to health, dietary phytonutrients are bitter, acid and/or astringent in taste and therefore reduce consumer choice and acceptance during food selection. Momordica charantia, commonly known as bitter melon has been traditionally used in Ayurvedic and Chinese medicine to treat diabetes and its complications. The aim of this study was to develop bitter melon-containing recipes and test their palatability and acceptability in healthy individuals for future clinical studies.

Author(s): 
Snee, Laura S.
Nerurkar, Vivek R.
Dooley, Dian A.
Efird, Jimmy T.
Shovic, Anne C.
Nerurkar, Pratibha V.
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Prostate cancer remains the second leading cause of cancer deaths among American men. Earlier diagnosis increases survival rate in patients. However, treatments for advanced disease are limited to hormone ablation techniques and palliative care. Thus, new methods of treatment and prevention are necessary for inhibiting disease progression to a hormone refractory state. One of the approaches to control prostate cancer is prevention through diet, which inhibits one or more neoplastic events and reduces the cancer risk.

Author(s): 
Ru, Peng
Steele, Robert
Nerurkar, Pratibha V.
Phillips, Nancy
Ray, Ratna B.
Publication Title: 
Pharmaceutical Research

The incidence of cancer is increasing worldwide, in spite of substantial progress in the development of anti-cancer therapies. One approach to control cancer could be its prevention by diet, which inhibits one or more neoplastic events and reduces cancer risk. Dietary compounds offer great potential in the fight against cancer by inhibiting the carcinogenesis process through the regulation of cell homeostasis and cell-death machineries.

Author(s): 
Nerurkar, Pratibha
Ray, Ratna B.
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Prostate cancer remains the second leading cause of cancer deaths among American men. Earlier diagnosis increases survival rate in patients. However, treatments for advanced disease are limited to hormone ablation techniques and palliative care. Thus, new methods of treatment and prevention are necessary for inhibiting disease progression to a hormone refractory state. One of the approaches to control prostate cancer is prevention through diet, which inhibits one or more neoplastic events and reduces the cancer risk.

Author(s): 
Ru, Peng
Steele, Robert
Nerurkar, Pratibha V.
Phillips, Nancy
Ray, Ratna B.
Publication Title: 
Phytotherapy research: PTR

The efficacy of Momordica charantia (MC), Eugenia jambolana (EJ), Tinospora cordifolia (TC) and Mucuna pruriens (MP) was assessed in the prevention of murine alloxan dibetic cataract. Alloxan (120 mg/kg) was used as the diabetogenic agent. While controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of MC and EJ (200 mg/kg p.o.), alcohol extract of TC (400 mg/kg) and MP (200 mg/kg p.o.) every day until 4 months. Serum glucose concentration was assessed and cataracts examined with both the naked eye and through a slit lamp.

Author(s): 
Rathi, S. S.
Grover, J. K.
Vikrant, Vats
Biswas, N. R.
Publication Title: 
Molecular and Cellular Biochemistry

Momordica charantia Linn., commonly called bitter gourd, is a medicinal plant used in the Ayurvedic system of medicine for treating various diseases including diabetes mellitus. Sodium orthovanadate (SOV) is also well-known insulin mimetic and an antidiabetic compound. Our laboratory has been using reduced doses of SOV along with administration of herbal extracts to alloxan diabetic rats and has established this combination as a good antihyperglycemic agent.

Author(s): 
Yadav, Umesh C. S.
Moorthy, K.
Baquer, Najma Z.
Publication Title: 
Pharmaceutical Research

The incidence of cancer is increasing worldwide, in spite of substantial progress in the development of anti-cancer therapies. One approach to control cancer could be its prevention by diet, which inhibits one or more neoplastic events and reduces cancer risk. Dietary compounds offer great potential in the fight against cancer by inhibiting the carcinogenesis process through the regulation of cell homeostasis and cell-death machineries.

Author(s): 
Nerurkar, Pratibha
Ray, Ratna B.
Publication Title: 
Journal of Medicinal Food

Momordica charantia L., commonly known as bitter gourd, is used as a vegetable by the Asian community in Africa. It is frequently used as an antidiabetic herb for the management of the disease in the Ayurvedic system of medicine. The present study was aimed at evaluating the effects of M. charantia on glucose level, lipid profiles, and oxidative stress in diabetic rats subjected to a sucrose load. Five normal rats and 20 diabetic rats (diabetes induced by injecting alloxan monohydrate) were used for the experiment.

Author(s): 
Chaturvedi, Padmaja
George, Saramma
Publication Title: 
Nutrition Journal

BACKGROUND: Although beneficial to health, dietary phytonutrients are bitter, acid and/or astringent in taste and therefore reduce consumer choice and acceptance during food selection. Momordica charantia, commonly known as bitter melon has been traditionally used in Ayurvedic and Chinese medicine to treat diabetes and its complications. The aim of this study was to develop bitter melon-containing recipes and test their palatability and acceptability in healthy individuals for future clinical studies.

Author(s): 
Snee, Laura S.
Nerurkar, Vivek R.
Dooley, Dian A.
Efird, Jimmy T.
Shovic, Anne C.
Nerurkar, Pratibha V.
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Prostate cancer remains the second leading cause of cancer deaths among American men. Earlier diagnosis increases survival rate in patients. However, treatments for advanced disease are limited to hormone ablation techniques and palliative care. Thus, new methods of treatment and prevention are necessary for inhibiting disease progression to a hormone refractory state. One of the approaches to control prostate cancer is prevention through diet, which inhibits one or more neoplastic events and reduces the cancer risk.

Author(s): 
Ru, Peng
Steele, Robert
Nerurkar, Pratibha V.
Phillips, Nancy
Ray, Ratna B.

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