Monophenol Monooxygenase

Publication Title: 
International Journal of Cosmetic Science

This study aimed to evaluate the free radical scavenging and inhibition properties of five medicinal plants, including Quercus infectoria Olive., Terminalia chebula Retz., Lavendula stoechas L., Mentha longifolia L., Rheum palmatum L., toward the activity of mushroom tyrosinase using L-tyrosine and L-3,4-dihydroxyphenylalanine (L-DOPA) as the substrate.The methanol extracts of Q. infectoria and T.

Khazaeli, P.
Goldoozian, R.
Sharififar, F.
Publication Title: 
Pharmaceutical Biology

CONTEXT: The Thai Lanna region has its own folklores and wisdoms in various fields such as traditional medicines. The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promoting longevity. OBJECTIVES: To investigate the in vitro anti-aging activities of the extracts from 15 plants including T. chebula gall selected from the Thai medicinal plant recipes that have been traditionally used for longevity.

Manosroi, Aranya
Jantrawut, Pensak
Akihisa, Toshihiro
Manosroi, Worapaka
Manosroi, Jiradej
Publication Title: 
Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine

OBJECTIVE: To confirm the inhibitory effect of Chinese herbs of acid taste on melanin synthesis. METHODS: Active ingredients of 22 kinds Chinese herbs of acid tastes were extracted by alkali extraction and acid precipitation, alcohol extraction, and water extraction, respectively, which was then dispensed into 25.00, 12.50, and 6.25 g/L suspension. Their effects on activities of tyrosinase were detected using mushroom-tyrosinase-DOPA speed oxidation. Their inhibition rates on activities of tyrosinase were respectively compared with inhibition rates of 1.0, 0.5, and 0.1 mmol/L arbutin.

Zhang, Li-ping
Liang, Juan
Chen, Bin
Wang, Ying-hao
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Recent studies have demonstrated a role for telomerase in driving tumor progression, but its mechanism of action remains unclear. Here we show that stable, ribozyme-mediated suppression of mouse telomerase RNA reduced telomerase RNA expression, telomerase activity, and telomere length, which significantly reduced tumor invasion and metastatic potential. Our studies reveal that previously unidentified effects of telomerase may mediate its tumor-promoting effects.

Bagheri, Sepideh
Nosrati, Mehdi
Li, Shang
Fong, Sylvia
Torabian, Sima
Rangel, Javier
Moore, Dan H.
Federman, Scot
Laposa, Rebecca R.
Baehner, Frederick L.
Sagebiel, Richard W.
Cleaver, James E.
Haqq, Christopher
Debs, Robert J.
Blackburn, Elizabeth H.
Kashani-Sabet, Mohammed
Publication Title: 
International Journal of Molecular Sciences

Essential oils extracted from aromatic plants exhibit important biological activities and have become increasingly important for the development of aromatherapy for complementary and alternative medicine. The essential oil extracted from Cinnamomum cassia Presl (CC-EO) has various functional properties; however, little information is available regarding its anti-tyrosinase and anti-melanogenic activities. In this study, 16 compounds in the CC-EO have been identified; the major components of this oil are cis-2-methoxycinnamic acid (43.06%) and cinnamaldehyde (42.37%).

Chou, Su-Tze
Chang, Wen-Lun
Chang, Chen-Tien
Hsu, Shih-Lan
Lin, Yu-Che
Shih, Ying
Publication Title: 
Human Gene Therapy

Thirty-three metastatic melanoma patients were vaccinated according to a phase I-II study with an allogeneic melanoma cell line that was genetically modified by transfection with a plasmid containing the gene encoding human interleukin 2 (IL-2). The cell line expresses the major melanoma-associated antigens and the HLA class I alleles HLA-A1, -A2, -B8, and Cw7. All patients shared one or more HLA class I alleles with this cell line vaccine.

Osanto, S.
Schiphorst, P. P.
Weijl, N. I.
Dijkstra, N.
Van Wees, A.
Brouwenstein, N.
Vaessen, N.
Van Krieken, J. H.
Hermans, J.
Cleton, F. J.
Schrier, P. I.
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Dou-chi, a traditional soybean food fermented with Aspergillus sp., is usually used as a seasoning in Chinese food, and has also been used as a folk medicine in China and Taiwan. As 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavengers, four phenol compounds, one isoflavanone, eight isoflavones and one 4-pyrone have been isolated from dou-chi. Among these fourteen compounds, 3'-hydroxydaidzein, dihydrodaidzein and a 4-pyrone compound have not yet been isolated from soybean miso.

Chen, Yu-Chi
Sugiyama, Yasumasa
Abe, Naoki
Kuruto-Niwa, Ryoko
Nozawa, Ryushi
Hirota, Akira
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Pyrostegia venusta is a native Brazilian plant which has a variety of uses in traditional folk medicine including the treatment of vitiligo. However, its effectiveness on melanogenesis is not yet elucidated. AIM OF THE STUDY: This study aimed to investigate the melanogenic activity of hydroalcoholic extracts from the leaves and flowers of P. venusta on murine B16F10 melanoma cells. MATERIALS AND METHODS: Different concentrations of the hydroalcoholic extracts of flowers and leaves of P.

Moreira, Camila G.
Horinouchi, Cintia D. S.
Souza-Filho, Claudio S.
Campos, Francinete R.
Barison, Andersson
Cabrini, Daniela A.
Otuki, Michel F.
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Glechoma hederacea L. (Labiatae) has been used in folk medicine to treat various ailments for centuries. We investigated the effects of G. hederacea extract on melanogenesis in B16 melanoma cells. It significantly reduced both the cellular melanin content and tyrosinase activity in a concentration-dependent manner. An MTT assay did not reveal any obvious cytotoxicity. Furthermore, we found that G.

Qiao, Zhiwei
Koizumi, Yukio
Zhang, Muxin
Natsui, Miyuki
Flores, Maria Jolina
Gao, Lina
Yusa, Kazuyuki
Koyota, Souichi
Sugiyama, Toshihiro
Publication Title: 
Biological & Pharmaceutical Bulletin

Saururus chinensis has been used in folk medicine in Korea for the treatment of edema, jaundice, gonorrhea, and several inflammatory diseases. Saururi chinensis extracts (SCE) have demonstrated anti-inflammatory and anti-oxidant activities, as well as anti-asthmatic, antihypertensive, anti-angiogenic, and therapeutic activities for atopic dermatitis. However, the inhibitory activity of SCE on the melanogenesis signaling pathway is not completely understood. This study examined the effects of SCE on the melanogenesis signaling pathway activated by α-melanocyte-stimulating hormone (α-MSH).

Lee, Do Hyun
Kim, Dong Ha
Oh, In Young
Kim, So Young
Lim, Yun Young
Kim, Hyeong Mi
Kim, Young Heui
Choi, Yoo Mi
Kim, Sung Eun
Kim, Beom Joon
Kim, Myeung Nam


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