Publication Title: 
Journal of Critical Care

PURPOSE: Sepsis and severe sepsis are the most common cause of death among critically ill patients admitted in medical intensive care units. As more than one-third of the adult population of the United States is obese; we undertook a systematic review of the association between obesity and mortality among patients admitted with sepsis, severe sepsis, or septic shock. MATERIALS AND METHODS: A systematic review was conducted to identify pertinent studies using a comprehensive search strategy. Studies reporting mortality in obese patients admitted with sepsis were identified.

Trivedi, Vrinda
Bavishi, Chirag
Jean, Raymonde
Publication Title: 
Neural Regeneration Research

OBJECTIVE: To evaluate the effectiveness and safety of the Xingnao Kaiqiao needling method for treating acute ischemic stroke. DATA SOURCES: We retrieved relevant randomized controlled trials involving Xingnao Kaiqiao acupuncture for treatment of acute ischemic stroke. The China National Knowledge Infrastructure, Weipu Information Resources System, Wanfang Medical Data System, Chinese Biomedical Literature Database, Cochrane Library, and PubMed were searched from June 2006 to March 2016.

Yang, Zhi-Xin
Xie, Jia-Hong
Liu, Ding-Ding
Publication Title: 
Neural Regeneration Research

OBJECTIVE: To systematically evaluate the long-term effect and safety of Xingnao Kaiqiao needling method in ischemic stroke treatment. DATA RETRIEVAL: We retrieved relevant random and semi-random controlled trials that used the Xingnao Kaiqiao needling method to treat ischemic stroke compared with various control treatments such as conventional drugs or other acupuncture therapies.

Yang, Zhi-Xin
Xie, Jia-Hong
Liu, Yong-Ping
Miao, Guang-Xin
Wang, Ying-Han
Wu, Sheng-Mei
Li, Yuan
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Fujita, T.
Publication Title: 
Recenti Progressi in Medicina

The 20th century will be remembered for its technological and scientific discoveries and for the exceptional changes in the demographic structure brought about by these and the improved economic and social conditions; in fact, the reduction in the birth rate and a fall in the death rate have caused an increase in the population of the elderly.

Cicconetti, Paolo
Riolo, Noemi
Ettorre, Evaristo
Costarella, Marianna
Priami, Carolina
Marigliano, Vincenzo
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess the cause of death for centenarians' offspring and controls. DESIGN: Cross-sectional study. SETTING: Community-based, nationwide sample. PARTICIPANTS: Family pedigree information was collected on 295 offspring of centenarians (from 106 families with a parent already enrolled in the nationwide New England Centenarian Study) and on 276 controls (from 82 control families) from 1997 to 2000. Controls were individuals whose parents were born in the same year as the centenarians but at least one of whom died at the average life expectancy.

Terry, Dellara F.
Wilcox, Marsha A.
McCormick, Maegan A.
Pennington, JaeMi Y.
Schoenhofen, Emily A.
Andersen, Stacy L.
Perls, Thomas T.
Publication Title: 
Aging Cell

We investigated the hypothesis that gene expression profiles in cultured cell lines from adults, aged 57-97 years, contain information about the biological age and potential longevity of the donors. We studied 104 unrelated grandparents from 31 Utah CEU (Centre d'Etude du Polymorphisme Humain - Utah) families, for whom lymphoblastoid cell lines were established in the 1980s.

Kerber, Richard A.
O'Brien, Elizabeth
Cawthon, Richard M.
Publication Title: 
American Journal of Human Biology: The Official Journal of the Human Biology Council

Frontier populations provide exceptional opportunities to test the hypothesis of a trade-off between fertility and longevity. In such populations, mechanisms favoring reproduction usually find fertile ground, and if these mechanisms reduce longevity, demographers should observe higher postreproductive mortality among highly fertile women.

Gagnon, Alain
Smith, Ken R.
Tremblay, Marc
VÈzina, HÈlËne
ParÈ, Paul-Philippe
Desjardins, Bertrand
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Few studies have examined whether the inflammatory markers IL-6 and C-reactive protein (CRP) are associated with exceptional longevity. OBJECTIVE: Our objective was to determine the association of serum CRP and IL-6 with adult lifespan. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, population-based study of 610 men and 743 postmenopausal women, mean age 73 yr, who had serum IL-6 and CRP measurements at baseline (1984-1987) and who were followed for mortality for up to 23 yr (through 2008).

Wassel, Christina L.
Barrett-Connor, Elizabeth
Laughlin, Gail A.
Publication Title: 
Science (New York, N.Y.)

Human senescence patterns-late onset of mortality increase, slow mortality acceleration, and exceptional longevity-are often described as unique in the animal world.

Bronikowski, Anne M.
Altmann, Jeanne
Brockman, Diane K.
Cords, Marina
Fedigan, Linda M.
Pusey, Anne
Stoinski, Tara
Morris, William F.
Strier, Karen B.
Alberts, Susan C.


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