Mouth Neoplasms

Publication Title: 
World Review of Nutrition and Dietetics

The dental problems of the elderly, though they may seem slight, can have far-reaching effects on both health and quality of life. The complexity and variety of potential physical and psychosocial problems of older citizens require a multidisciplinary management approach. Dental team members need to target appropriate resources outside of the dental office, and nondental care providers need to attend to dental needs as well as other more evident problems. Only in this way can we help to optimize the health and longevity of this ever-increasing segment of the population.

Author(s): 
Palmer, C. A.
Papas, A. S.
Publication Title: 
Oral Oncology

OBJECTIVES: The objective of this study was to identify novel survival-associated biomarkers in oral rinse samples collected from patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: We screened for putative survival-associated markers using publicly available methylation array data from 88 OSCC tumors. Cox models were then fit to methylation array data restricted to these putative loci in oral rinse samples of 82 OSCC patients from greater Boston.

Author(s): 
Langevin, Scott M.
Butler, Rondi A.
Eliot, Melissa
Pawlita, Michael
Maccani, Jennifer Z. J.
McClean, Michael D.
Kelsey, Karl T.
Publication Title: 
Annals of the Royal College of Surgeons of England
Author(s): 
Thompson, P. W.
Publication Title: 
Anticancer Research

Artemisinin (AR) is a widely used antimalarial drug. Recently, additional uses for AR as an anticancer drug were discovered. Using TUNEL, immunohistochemistry (IHS) markers and flow cytometry techniques, we evaluated the effect of AR and 5-FU on HPV 16 immortalized and transformed human gingival epithelial (IHGK) cells. The results of TUNEL showed that AR-treated IHGK cells consisted of 82% positive cells, while 5-FU-treated cells consisted of 18% positive cells.

Author(s): 
Yamachika, Eiki
Habte, Temesgen
Oda, Dolphine
Publication Title: 
Chemical & Pharmaceutical Bulletin

Novel artemisinin-glycolipid hybrids were directly synthesized from 12? (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 µM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.

Author(s): 
Ricci, Jérémy
Kim, Minkyu
Chung, Won-Yoon
Park, Kwang-Kyun
Jung, Mankil
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal. The epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription (STAT)-3 signaling pathway is known to play a key role in HNSCC growth, survival, and prognosis, thereby serving as a potential therapeutic target in the treatment of HNSCC.

Author(s): 
Leeman-Neill, Rebecca J.
Seethala, Raja R.
Singh, Shivendra V.
Freilino, Maria L.
Bednash, Joseph S.
Thomas, Sufi M.
Panahandeh, Mary C.
Gooding, William E.
Joyce, Sonali C.
Lingen, Mark W.
Neill, Daniel B.
Grandis, Jennifer R.
Publication Title: 
Arzneimittel-Forschung

Areca cattechu Linn is commonly known as areca nut or betel nut. It is a very widely cultivated plant in eastern countries like India, Bangladesh, Ceylon, Malaya, the Philippines and Japan. The importance of this nut is due to its use for chewing purposes. It had an important place as a pharmaceutical in Ayurveda--the ancient Indian system of medicine--also in the Chinese medicinal practices. The pharmaceutical importance of areca nut is due to the presence of an alkaloid, arecoline. Synthetic arecoline hydrobromide is also shown to possess numerous pharmacological properties.

Author(s): 
Arjungi, K. N.
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal. The epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription (STAT)-3 signaling pathway is known to play a key role in HNSCC growth, survival, and prognosis, thereby serving as a potential therapeutic target in the treatment of HNSCC.

Author(s): 
Leeman-Neill, Rebecca J.
Seethala, Raja R.
Singh, Shivendra V.
Freilino, Maria L.
Bednash, Joseph S.
Thomas, Sufi M.
Panahandeh, Mary C.
Gooding, William E.
Joyce, Sonali C.
Lingen, Mark W.
Neill, Daniel B.
Grandis, Jennifer R.
Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: EF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels, and prognostic significance of hypoxia in primary head and neck squamous cell tumors. METHODS AND MATERIALS: Twenty-two patients with newly diagnosed squamous cell carcinoma of the oral cavity, oropharynx, or larynx with at least 2 years of clinical follow-up were included in this study. Quantitative analyses of EF5 immunofluorescence was carried out, and these data were compared with patient outcome. RESULTS: EF5 immunostaining showed substantial intra- and intertumoral hypoxic heterogeneity.

Author(s): 
Evans, Sydney M.
Du, Kevin L.
Chalian, Ara A.
Mick, Rosemarie
Zhang, Paul J.
Hahn, Stephen M.
Quon, Harry
Lustig, Robert
Weinstein, Gregory S.
Koch, Cameron J.
Publication Title: 
Journal of Neuro-Oncology

We have examined 17 patients suffering from recurrent syncope caused by carcinoma of the head and neck. The tumor originated in the mouth in seven, larynx in six, nasopharynx in three and parotid gland in one, and involved cervical lymph nodes at diagnosis in 12. Sixteen patients had previously had radical neck dissections and 12 had had radiation therapy. Recurrent carcinoma was present in 16. Spells resolved spontaneously in four, improved with treatment in 11 and continued in two. The syncope was spontaneous in 15 and induced only by suctioning or carotid sinus massage in two.

Author(s): 
Macdonald, D. R.
Strong, E.
Nielsen, S.
Posner, J. B.

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