MPTP Poisoning

Publication Title: 
Neurochemical Research

Hyoscyamus species is one of the four plants used in Ayurveda for the treatment of Parkinson's disease (PD). Since Hyoscyamus niger was found to contain negligible levels of L-DOPA, we evaluated neuroprotective potential, if any, of characterized petroleum ether and aqueous methanol extracts of its seeds in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. Air dried authenticated H. niger seeds were sequentially extracted using petroleum ether and aqueous methanol and were characterized employing HPLC-electrochemistry and LCMS.

Author(s): 
Sengupta, T.
Vinayagam, J.
Nagashayana, N.
Gowda, B.
Jaisankar, P.
Mohanakumar, K. P.
Publication Title: 
Parkinsonism & Related Disorders

The stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian (HP) rhesus monkey model of Parkinson's disease (PD) has been frequently used to test preclinical experimental therapeutics targeted to treat patients with advanced PD who suffer from motor fluctuations and drug-induced dyskinesias. We retrospectively analyzed data from 17 stable HP rhesus monkeys treated long-term with chronic intermittent dosing of levodopa (LD) in an attempt to induce choreoathetoid and dystonic dyskinesias.

Author(s): 
Lieu, Christopher A.
Deogaonkar, Milind
Bakay, Roy A. E.
Subramanian, Thyagarajan
Publication Title: 
Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics

Consumption of coffee is associated with reduced risk of Parkinson's disease (PD), an effect that has largely been attributed to caffeine. However, coffee contains numerous components that may also be neuroprotective. One of these compounds is eicosanoyl-5-hydroxytryptamide (EHT), which ameliorates the phenotype of α-synuclein transgenic mice associated with decreased protein aggregation and phosphorylation, improved neuronal integrity and reduced neuroinflammation. Here, we sought to investigate if EHT has an effect in the MPTP model of PD.

Author(s): 
Lee, Kang-Woo
Im, Joo-Young
Woo, Jong-Min
Grosso, Hilary
Kim, Yoon-Seong
Cristovao, Ana Clara
Sonsalla, Patricia K.
Schuster, David S.
Jalbut, Marla M.
Fernandez, Jose R.
Voronkov, Michael
Junn, Eunsung
Braithwaite, Steven P.
Stock, Jeffry B.
Mouradian, M. Maral
Publication Title: 
Journal of Neuroscience Methods

Although acupuncture has been widely and routinely used in healthcare in the USA, its use has been based more on empirical observation than on scientific knowledge. Therefore, there is a great need for better understanding the underlying mechanism(s) of action. A great body of evidence supports that nonhuman primates are a candidate for studying human diseases. However, the use of nonhuman primates in neurophysiological, neuroimaging and neurochemical studies is extremely challenging, especially under fully conscious, alert conditions.

Author(s): 
Zhao, Feng
Fan, Xiaotong
Grondin, Richard
Edwards, Ramsey
Forman, Eric
Moorehead, Jennifer
Gerhardt, Greg
Wang, Xiaomin
Zhang, Zhiming
Publication Title: 
PloS One

Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. In the present study we administered 100 Hz EA stimulation at the two acupoints to MPTP-lesioned mice for 12 sessions starting from the day prior to the first MPTP injection.

Author(s): 
Wang, Haomin
Pan, Yanli
Xue, Bing
Wang, Xinhong
Zhao, Feng
Jia, Jun
Liang, Xibin
Wang, Xiaomin
Publication Title: 
PloS One

Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that bilateral acupoint stimulation of lower hind limbs with bee venom was protective in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no information regarding a potential protective action of apamin in animal models of PD is available to date.

Author(s): 
Alvarez-Fischer, Daniel
Noelker, Carmen
Vulinović, Franca
Grünewald, Anne
Chevarin, Caroline
Klein, Christine
Oertel, Wolfgang H.
Hirsch, Etienne C.
Michel, Patrick P.
Hartmann, Andreas
Publication Title: 
PloS One

Bradykinesia is one of the major clinical symptoms of Parkinson`s disease (PD) for which treatment is sought. In most mouse models of PD, decreased locomotor activity can be reflected in an open field behavioral test. Therefore the open field test provides a useful tool to study the clinic symptoms of PD patients. Our previous work demonstrated that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI and SANYINJIAO protected the dopaminergic nigrostriatal system of C57BL/6 mice from MPTP toxicity, indicating that acupuncture might be an effective therapy for PD sufferers.

Author(s): 
Wang, Haomin
Liang, Xibin
Wang, Xuan
Luo, Dingzhen
Jia, Jun
Wang, Xiaomin
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