Mucin 5AC

Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized. OBJECTIVE: To evaluate lung inflammation, mucus metaplasia and AHR in relationship with age in murine models of allergic asthma comparing young and older mice. METHODS: Young (6 weeks) and older (6, 12, 18 months) BALB/c mice were sensitized and challenged with ovalbumin (OVA).

Author(s): 
Busse, Paula J.
Zhang, Teng Fei
Srivastava, Kamal
Schofield, Brian
Li, Xiu-Min
Publication Title: 
Toxicologic Pathology

Compared to healthy subjects, individuals with allergic airway disease (e.g., asthma, allergic rhinitis) have enhanced inflammatory responses to inhaled ozone. We created a rodent model of ozone-enhanced allergic nasal responses in Brown Norway rats to test the therapeutic effects of the dietary supplement gamma-tocopherol (gammaT). Ovalbumin (OVA)-sensitized rats were intranasally challenged with 0% or 0.5% OVA (in saline) on Days 1 and 2, and then exposed to 0 or 1 ppm ozone (eight hours/day) on Days 4 and 5.

Author(s): 
Wagner, James G.
Harkema, Jack R.
Jiang, Qing
Illek, Beate
Ames, Bruce N.
Peden, David B.
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Viral infection is associated with approximately one-half of acute exacerbations of chronic obstructive pulmonary disease (COPD), which in turn, accelerate disease progression. In this study, we infected mice exposed to a combination of elastase and LPS, a constituent of cigarette smoke and a risk factor for development of COPD, with rhinovirus serotype 1B, and examined animals for viral persistence, airway resistance, lung volume, and cytokine responses.

Author(s): 
Sajjan, Umadevi
Ganesan, Shyamala
Comstock, Adam T.
Shim, Jee
Wang, Qiong
Nagarkar, Deepti R.
Zhao, Ying
Goldsmith, Adam M.
Sonstein, Joanne
Linn, Marisa J.
Curtis, Jeffrey L.
Hershenson, Marc B.
Publication Title: 
Toxicologic Pathology

Compared to healthy subjects, individuals with allergic airway disease (e.g., asthma, allergic rhinitis) have enhanced inflammatory responses to inhaled ozone. We created a rodent model of ozone-enhanced allergic nasal responses in Brown Norway rats to test the therapeutic effects of the dietary supplement gamma-tocopherol (gammaT). Ovalbumin (OVA)-sensitized rats were intranasally challenged with 0% or 0.5% OVA (in saline) on Days 1 and 2, and then exposed to 0 or 1 ppm ozone (eight hours/day) on Days 4 and 5.

Author(s): 
Wagner, James G.
Harkema, Jack R.
Jiang, Qing
Illek, Beate
Ames, Bruce N.
Peden, David B.
Publication Title: 
Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences

OBJECTIVE: To explore the therapeutic effects and mechanisms of the combination of traditional Chinese medicine and western medicine on patients with peptic ulcers. METHODS: One hundred and twenty patients were randomly divided into 6 groups. Another 10 patients as the control group were confirmed with no peptic ulcers by endoscope, but had digestive tract symptoms. The clinical effects were compared among each group after the one month treatment.

Author(s): 
Zhou, Bing
Li, Jia-bang
Cai, Guang-Xian
Ling, Jiang-hong
Dai, Xing-ping
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