Multicenter Studies as Topic

Publication Title: 
European Journal of Medical Research

The results from studies on potential treatment effects of acupuncture are often limited due to serious difficulties in methodology. Randomized controlled trials on acupuncture should test a widely accepted treatment strategy of verum and sham acupuncture. However, in clinical practice various patterns of acupuncture techniques are employed, and up to now no generally accepted guidelines on how to perform a reliable verum or sham treatment have been established.

Author(s): 
Molsberger, Albrecht F.
Mau, J.
Gotthardt, H.
Schneider, T.
Drabik, A.
Publication Title: 
Explore (New York, N.Y.)

OBJECTIVE: Using metaanalysis to examine the effects of acustimulations on nausea and vomiting symptoms (NVS) in postoperative adult populations. METHODS: Metaanalyses of effects of various acupoints stimulations (AS) (including acupuncture, acupressure, and electrical stimulation) on NVS in postoperative adult populations were performed. Thirty-three quality randomized controlled trials (RCT) published over the past three decades were identified by evaluating the quality of randomization and treatment methods, and results were pooled using a fixed effects model.

Author(s): 
Shiao, Shyang-Yun Pamela K.
Dune, Linda S.
Publication Title: 
Explore (New York, N.Y.)

OBJECTIVE: Using metaanalysis, we sought to determine acustimulation (AS) effects on postoperative nausea and vomiting (PONV) in children. METHODS: Metaanalyses were performed on various acupoint AS effects including acupressure, acupuncture, laser acupuncture, and electrical stimulation (ETS) on PONV in children. On-line databases were searched for randomized controlled trials (RCTs) from 1966 through May 2005. In addition, the reference lists of reviewed papers were scanned for additional trials.

Author(s): 
Dune, Linda S.
Shiao, Shyang-Yun Pamela K.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: In the nationwide German Acupuncture Trials (GERAC), verum acupuncture, mirroring the Traditional Chinese Medicine (TCM) acupuncture style, was tested against sham acupuncture and guideline standard therapy for the entities classified in the West as chronic low back pain (LBP) and gonarthrosis (GON). OBJECTIVE: The objective was to develop broadly consensual acupuncture and control protocols for the treatment of LBP and GON in the GERAC trials. METHODOLOGY: Extensive literature study and consultation with acupuncture experts were consulted.

Author(s): 
Molsberger, Albrecht F.
Streitberger, Konrad
Kraemer, Juergen
Brittinger, Carmen Schade
Witte, Steffen
Boewing, Gabriele
Haake, Michael
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: In the nationwide German Acupuncture Trials (GERAC), verum acupuncture, mirroring the Traditional Chinese Medicine (TCM) acupuncture style, was tested against sham acupuncture and guideline standard therapy for the entities classified in the West as chronic low back pain (LBP) and gonarthrosis (GON). OBJECTIVE: The objective was to develop broadly consensual acupuncture and control protocols for the treatment of LBP and GON in the GERAC trials. METHODOLOGY: Extensive literature study and consultation with acupuncture experts were consulted.

Author(s): 
Molsberger, Albrecht F.
Streitberger, Konrad
Kraemer, Juergen
Brittinger, Carmen Schade
Witte, Steffen
Boewing, Gabriele
Haake, Michael
Publication Title: 
Maternal and Child Health Journal

AIMS: The goal of this article is to introduce the Research on Sexually Transmitted Diseases, Violence, and Pregnancy Prevention Project (RSVPP), which represents one response of the National Institutes of Health to reduce health disparities in racial and ethnic populations. METHODS: As part of this effort, seven independent projects were funded to design, implement, and evaluate community-based intervention strategies aimed at reducing risk behaviors among minority youth.

Author(s): 
Browne, D. C.
Clubb, P. A.
Aubrecht, A. M.
Jackson, M.
Publication Title: 
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology

PURPOSE: To identify areas of concern regarding the conduct of phase I trials, the perceived expectations and motivations of the parents of children entered, the expectations of toxicity and benefit, and the ethical concerns of pediatric hematologists and oncologists in the United Kingdom and North America. METHODS: A survey instrument consisting of 19 open- and closed-ended questions was sent to United Kingdom Children's Cancer Study Group (UKCCSG)- and Pediatric Oncology Group (POG)-affiliated pediatricians. RESULTS: Fifty-three UKCCSG- and 78 POG-affiliated pediatricians responded.

Author(s): 
Estlin, E. J.
Cotterill, S.
Pratt, C. B.
Pearson, A. D.
Bernstein, M.
Publication Title: 
AIDS (London, England)

OBJECTIVES: We wished to identify which potential mediators of the Seropositive Urban Men's Intervention Trial (SUMIT) intervention were in fact changed by the intervention, and further to identify which among these factors distinguished men who decreased their risk behavior relative to those who increased it, irrespective of the intervention arm. METHODS: We examined social cognitive theory and other psychosocial variables that the intervention was designed to affect (potential mediators) in both sets of analyses.

Author(s): 
O'Leary, Ann
Hoff, Colleen C.
Purcell, David W.
GÛmez, Cynthia A.
Parsons, Jeffrey T.
Hardnett, Felicia
Lyles, Cynthia M.
Publication Title: 
Contemporary Clinical Trials

One of the most influential factors in science and medicine has been the development of placebo-controlled clinical trials. However, recruitment of patients for clinical trials is sometimes a major problem in clinical research. Successful patient recruitment may be enhanced with a clear understanding of the motivating factors that determine a patient's decision to enter a study.

Author(s): 
Rojavin, Mikhail A.
Downs, Pamela
Shetzline, Michael A.
Chilingerian, Raffy
Cohard-Radice, Marielle
Publication Title: 
AIDS (London, England)

OBJECTIVE: To describe the community popular opinion leader (C-POL) intervention employed in the NIMH Collaborative HIV/STD Prevention Trial, including its theoretical, conceptual, and empirical basis, intervention procedures and methods, core elements, and how its content was culturally tailored to address the needs of varied populations.

Author(s): 
NIMH Collaborative HIV/STD Prevention Trial Group

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