Multigene Family

Publication Title: 
Plant Physiology

Root-knot nematode (RKN) Meloidogyne species are major polyphagous pests of most crops worldwide, and cultivars with durable resistance are urgently needed because of nematicide bans. The Ma gene from the Myrobalan plum (Prunus cerasifera) confers complete-spectrum, heat-stable, and high-level resistance to RKN, which is remarkable in comparison with the Mi-1 gene from tomato (Solanum lycopersicum), the sole RKN resistance gene cloned. We report here the positional cloning and the functional validation of the Ma locus present at the heterozygous state in the P.2175 accession.

Claverie, Michel
Dirlewanger, Elisabeth
Bosselut, Nathalie
Van Ghelder, Cyril
Voisin, Roger
Kleinhentz, Marc
Lafargue, Bernard
Abad, Pierre
Rosso, Marie-Noëlle
Chalhoub, Boulos
Esmenjaud, Daniel
Publication Title: 
PloS One

Several studies have shown that genetic factors account for 25% of the variation in human life span. On the basis of published molecular, genetic and epidemiological data, we hypothesized that genetic polymorphisms of taste receptors, which modulate food preferences but are also expressed in a number of organs and regulate food absorption processing and metabolism, could modulate the aging process.

Campa, Daniele
de Rango, Francesco
Carrai, Maura
Crocco, Paolina
Montesanto, Alberto
Canzian, Federico
Rose, Giuseppina
Rizzato, Cosmeri
Passarino, Giuseppe
Barale, Roberto
Publication Title: 
Molecular Aspects of Medicine

The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane. SLC16A2 encodes a high affinity thyroid hormone transporter (MCT8) and SLC16A10 an aromatic amino acid transporter (TAT1). The substrates and roles of the remaining eight members are unknown.

Halestrap, Andrew P.
Publication Title: 
BMC medical genomics

BACKGROUND: Despite their singular origin, monozygotic twin pairs often display discordance for complex disorders including schizophrenia. It is a common (1%) and often familial disease with a discordance rate of ~50% in monozygotic twins. This high discordance is often explained by the role of yet unknown environmental, random, and epigenetic factors. The involvement of DNA methylation in this disease appears logical, but remains to be established.

Castellani, Christina A.
Laufer, Benjamin I.
Melka, Melkaye G.
Diehl, Eric J.
O'Reilly, Richard L.
Singh, Shiva M.
Publication Title: 

The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P.

Carlton, Jane M.
Adams, John H.
Silva, Joana C.
Bidwell, Shelby L.
Lorenzi, Hernan
Caler, Elisabet
Crabtree, Jonathan
Angiuoli, Samuel V.
Merino, Emilio F.
Amedeo, Paolo
Cheng, Qin
Coulson, Richard M. R.
Crabb, Brendan S.
Del Portillo, Hernando A.
Essien, Kobby
Feldblyum, Tamara V.
Fernandez-Becerra, Carmen
Gilson, Paul R.
Gueye, Amy H.
Guo, Xiang
Kang'a, Simon
Kooij, Taco W. A.
Korsinczky, Michael
Meyer, Esmeralda V.-S.
Nene, Vish
Paulsen, Ian
White, Owen
Ralph, Stuart A.
Ren, Qinghu
Sargeant, Tobias J.
Salzberg, Steven L.
Stoeckert, Christian J.
Sullivan, Steven A.
Yamamoto, Marcio M.
Hoffman, Stephen L.
Wortman, Jennifer R.
Gardner, Malcolm J.
Galinski, Mary R.
Barnwell, John W.
Fraser-Liggett, Claire M.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The effect of antimalarial drug selection on pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from two distinct geographical locations was determined in 70 and 18 P. falciparum isolates from Nigeria and Brazil, respectively, using nested polymerase chain reaction and direct DNA sequencing approaches. All isolates from Brazil and 72% from Nigeria harbored the mutant SVMNT and CVIET pfcrt haplotype, respectively. The pfcrt CVMNT haplotype was also observed in (7%) of the Nigerian samples.

Gbotosho, Grace O.
Folarin, Onikepe A.
Bustamante, Carolina
da Silva, Luis Hildebrando Pereira
Mesquita, Elieth
Sowunmi, Akintunde
Zalis, Mariano G.
Oduola, Ayoade M. J.
Happi, Christian T.
Publication Title: 
International Journal of Molecular Sciences

Thapsia laciniata Rouy (Apiaceae) produces irregular and regular sesquiterpenoids with thapsane and guaiene carbon skeletons, as found in other Apiaceae species. A transcriptomic analysis utilizing Illumina next-generation sequencing enabled the identification of novel genes involved in the biosynthesis of terpenoids in Thapsia. From 66.78 million HQ paired-end reads obtained from T. laciniata roots, 64.58 million were assembled into 76,565 contigs (N50: 1261 bp). Seventeen contigs were annotated as terpene synthases and five of these were predicted to be sesquiterpene synthases.

Drew, Damian Paul
Dueholm, Bjørn
Weitzel, Corinna
Zhang, Ye
Sensen, Christoph W.
Simonsen, Henrik Toft
Publication Title: 

In humans, uridine 5'-diphosphate glucuronosyltransferase (UGT) operates in opposition to glucuronidase (GUS) to control activity of diverse metabolites such as hormones by reversible conjugation with glucuronic acid. Previous data revealed that, as in mammals, these enzymes are required for plant life in that a UGT from Pisum sativum (PsUGT1) controls plant development by opposing endogenous GUS activity thereby modulating the duration of the cell cycle.

Woo, Ho-Hyung
Jeong, Byeong Ryong
Hirsch, Ann M.
Hawes, Martha C.
Publication Title: 
Archives of Biochemistry and Biophysics

Efficient iron acquisition is critical for an invading microbe's survival and virulence. Most of the iron in mammals is incorporated into heme, which can be plundered by certain bacterial pathogens as a nutritional iron source. Utilization of exogenous heme by bacteria involves the binding of heme or hemoproteins to the cell surface receptors, followed by the transport of heme into cells. Once taken into the cytosol, heme is presented to heme oxygenases where the tetrapyrrole ring is cleaved in order to release the iron.

Tong, Yong
Guo, Maolin
Publication Title: 
Journal of Lipid Research

Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation through their capacity to be converted to potent inflammatory mediators. We assessed associations of FADS gene cluster polymorphisms and fasting serum PUFA concentrations in a fully ascertained, geographically isolated founder population of European descent. Concentrations of 22 PUFAs were determined by gas chromatography, of which ten fatty acids and five ratios defining FADS1 and FADS2 activity were tested for genetic association against 16 single nucleotide polymorphisms (SNP) in 224 individuals.

Mathias, Rasika A.
Vergara, Candelaria
Gao, Li
Rafaels, Nicholas
Hand, Tracey
Campbell, Monica
Bickel, Carol
Ivester, Priscilla
Sergeant, Susan
Barnes, Kathleen C.
Chilton, Floyd H.


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