Mutagens

Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

A study to evaluate an antimutagenic potential of water, chloroform and acetone extracts of Triphala has been made in an Ames histidine reversion assay using TA98 and TA100 tester strains of Salmonella typhimurium against the direct-acting mutagens, 4-nitro-o-phenylenediamine (NPD) and sodium azide, and the indirect-acting promutagen, 2-aminofluorene (2AF), in the presence of phenobarbitone-induced rat hepatic S9. A combination drug 'Triphala' - a composite mixture of Terminalia bellerica, T.

Author(s): 
Kaur, S.
Arora, S.
Kaur, K.
Kumar, S.
Publication Title: 
Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer

We report the results of our genotoxic evaluation of extracts from three medicinal plants Acacia nilotica, Juglans regia, and Terminalia chebula and the herbal drug Triphala employing the VITOTOX and comet tests.These tests detect DNA damage in prokaryotic and eukaryotic test systems, respectively. In the VITOTOX test, none of the extracts were identified as genotoxic.

Author(s): 
Arora, Saroj
Brits, Ethel
Kaur, Swayamjot
Kaur, Kamaljeet
Sohi, Rajbir S.
Kumar, Subodh
Verschaeve, Luc
Publication Title: 
Phytotherapy research: PTR

The fruit of Terminalia chebula Retz. (T. chebula), which is a member of the Combfreetaceae family, is used widely in Asian countries as a traditional folk medicine, and its extract has been reported to be an anticancer, antidiabetic and anticaries agent. In our previous study, chebulic acid isolated from T. chebula extract was confirmed to show antioxidant activity and protective action against endothelial cell dysfunction. In order to support the safety-in-use of the ethyl acetate (EtOAc)-soluble portion of a T.

Author(s): 
Kim, Ji-hoon
Koo, Yun-chang
Hong, Chung-Oui
Yang, Sung-Yong
Jun, Woojin
Lee, Kwang-Won
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The decoction of Terminalia chebula fruit is an ayurvedic remedy whose prolonged oral administration is prized as a generic intestinal and hepatic detoxifying agent. Its administration is suggested also under the perspective of a reduced risk of cancer, metabolic and cardiovascular diseases. AIM OF THE STUDY: To evaluate the phytochemical profile and the chemopreventive potential of Terminalia chebula fruit decoction prepared according to the ayurvedic decoction recipe.

Author(s): 
Pellati, Federica
Bruni, Renato
Righi, Davide
Grandini, Alessandro
Tognolini, Massimilano
Pio Prencipe, Francesco
Poli, Ferruccio
Benvenuti, Stefania
Del Rio, Daniele
Rossi, Damiano
Publication Title: 
PloS One

Borage (Borago officinalis L.) seed oil has been used as a treatment for various degenerative diseases. Many useful properties of this oil are attributed to its high gamma linolenic acid content (GLA, 18:3 ?-6). The purpose of this study was to demonstrate the safety and suitability of the use of borage seed oil, along with one of its active components, GLA, with respect to DNA integrity, and to establish possible in vivo toxic and in vitro cytotoxic effects.

Author(s): 
Tasset-Cuevas, Inmaculada
Fern·ndez-Bedmar, Zahira
Lozano-Baena, MarÌa Dolores
Campos-S·nchez, Juan
de Haro-BailÛn, Antonio
MuÒoz-Serrano, AndrÈs
Alonso-Moraga, Angeles
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

The French paradox is a dietary anomaly which has focused attention on the Mediterranean diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium and Brassica vegetables, and red wine), correlated with the increased longevity and decreased incidence of cardiovascular disease seen in these populations. The most frequently studied flavonoid, quercetin, has been shown to have biological properties consistent with its sparing effect on the cardiovascular system.

Author(s): 
Formica, J. V.
Regelson, W.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Artesunate is a derivate of artemisinin that is both an antimalarial agent and acts cytotoxically on tumor cells. Despite its therapeutic use, its in vivo genotoxic potential has still not been evaluated. This study, therefore, was an investigation into the effects of a single oral administration of artesunate with an in vivo comet assay that analyzed leukocytes from peripheral blood and liver cells, and a micronucleus (MN) assay of bone marrow cells from male Swiss mice. The artesunate was administered by oral gavage at doses of 5, 50 and 100 mg/kg.

Author(s): 
Aquino, Ivani
Perazzo, Fábio Ferreira
Maistro, Edson Luis
Publication Title: 
Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer

Compounds possessing antimutagenic properties (polyphenols, tannins, vitamins, etc.) have been identified in fruits, vegetables, spices, and medicinal plants. Terminalia arjuna (Combretaceae), a tropical woody tree occurring throughout India and known locally as Kumbuk, is a medicinal plant rich in tannins and triterpenes that is used extensively in Ayurvedic medicine as a cardiac tonic. The aim of the present collaborative work was to test six solvent extracts from the bark of Terminalia arjuna for antigenotoxic activity using in vitro short-term tests.

Author(s): 
Scassellati-Sforzolini, G.
Villarini, L. M.
Moretti, L. M.
Marcarelli, L. M.
Pasquini, R.
Fatigoni, C.
Kaur, L. S.
Kumar, S.
Grover, I. S.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

We have undertaken the studies to investigate the presence of various activities of the leaf extract of Ashwagandha (Lash), a commonly used shrub in Indian traditional medicine, Ayurveda. In the present study, we studied the effect of Lash against MNNG-induced genotoxicity in onion root tip cells. We report that Lash offered substantial protection against the mutagenic effects of MNNG.

Author(s): 
Rani, G.
Kaur, K.
Wadhwa, R.
Kaul, S. C.
Nagpal, A.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Salacia oblonga has been used for thousands of years in Ayurvedic medicine for the oral treatment of diabetes. The root extract has been shown to inhibit the activity of intestinal alpha-glucosidases, therefore S. oblonga holds potential as a natural method to mitigate the blood glucose response for people with diabetes. As part of a safety evaluation of novel ingredients for use in blood glucose control, the potential genotoxicity of a S.

Author(s): 
Flammang, A. M.
Erexson, G. L.
Mecchi, M. S.
Murli, H.

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