Myelin Proteins

Publication Title: 

Steroidal estrogens can regulate inflammatory immune responses and may be involved in the suppression of multiple sclerosis (MS) during pregnancy. However, the risks and side effects associated with steroidal estrogens may limit their usefulness for long-term MS therapy. Selective estrogen receptor modulators (SERMs) could provide an alternative therapeutic strategy, because they behave as estrogen agonists in some tissues, but are either inert or behave like estrogen antagonists in other tissues.

Bebo, Bruce F.
Dehghani, Babak
Foster, Scott
Kurniawan, Astrid
Lopez, Francisco J.
Sherman, Larry S.
Publication Title: 
Neurobiology of Disease

Charcot-Marie-Tooth type 1A (CMT1A) neuropathies linked to the misexpression of peripheral myelin protein 22 (PMP22) are progressive demyelinating disorders of the peripheral nervous system. In this study we asked whether dietary restriction by intermittent fasting (IF) could alleviate the neuropathic phenotype in the Trembler J (TrJ) mouse model of CMT1A. Our results show that neuropathic mice kept on a five month long IF regimen had improved locomotor performance compared to ad libitum (AL) fed littermates.

Madorsky, Irina
Opalach, Katherine
Waber, Amanda
Verrier, Jonathan D.
Solmo, Chelsea
Foster, Thomas
Dunn, William A.
Notterpek, Lucia
Publication Title: 
Journal of Lipid Research

Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. However, relatively less is known regarding its role in neurological functions. Using shotgun lipidomics, we investigated the lipidome of mouse cerebral cortex with generalized deficiency of PGC-1α (PGC-1α(-/-)) versus wild-type (WT) mice under standard diet and chronically calorically restricted conditions.

Kiebish, Michael A.
Young, Dee M.
Lehman, John J.
Han, Xianlin
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Berbamine (BM) is an herbal compound derived from Berberis vulgaris L commonly used in traditional Chinese medicine. In this study, we show that BM has potent anti-inflammatory properties through novel regulatory mechanisms, leading to reduced encephalitogenic T cell responses and amelioration of experimental autoimmune encephalomyelitis (EAE). The treatment effect of BM was attributable to its selective inhibitory effect on the production and action of IFN-gamma in CD4(+) T cells, which was mediated through altered STAT4 expression in T cells.

Ren, Yiping
Lu, Limin
Guo, Taylor B.
Qiu, Ju
Yang, Yiqing
Liu, Ailian
Zhang, Jingwu Z.
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