Myostatin

Publication Title: 
Age (Dordrecht, Netherlands)

The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. mammalian target of rapamycin. We compared allele/genotype distributions of the exonic MSTN variants K153R (rs1805086), E164K (rs35781413), I225T and P198A, in Spanish centenarians (cases, n = 156; 132 women, age range 100-111 years) and younger adults (controls, n = 384; 167 women, age <50 years).

Author(s): 
Garatachea, Nuria
PinÛs, Tom‡s
C·mara, Yolanda
RodrÌguez-Romo, Gabriel
Emanuele, Enzo
Ricevuti, Giovanni
Venturini, Letizia
Santos-Lozano, Alejandro
Santiago-Dorrego, Catalina
Fiuza-Luces, Carmen
Yvert, Thomas
Andreu, Antoni L.
Lucia, Alejandro
Publication Title: 
Physiological Genomics

Complementary and alternative medicine (CAM) may provide patients with an alternative to traditional medicine, but an assessment of its efficacy is required. One CAM method, electroacupuncture (EA) treatment, is a maneuver that utilizes stimulation of acupuncture needles with a low-frequency microcurrent. To study the effect of short-term EA, we evaluated the differential expression of genes induced by EA in mouse skeletal muscle for up to 24 h. We then used RT-PCR to confirm the expression patterns of six differentially expressed genes.

Author(s): 
Takaoka, Yutaka
Ohta, Mika
Ito, Akihiko
Takamatsu, Kunihiko
Sugano, Aki
Funakoshi, Kotaro
Takaoka, Nobuo
Sato, Nobuko
Yokozaki, Hiroshi
Arizono, Naoki
Goto, Shuji
Maeda, Eiichi
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