NADH Dehydrogenase

Publication Title: 
Human Molecular Genetics

The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Significantly, the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has been mapped. Previously, we have shown that Cisd2 deficiency shortens lifespan resulting in premature aging in mice. Additionally, an age-dependent decrease in Cisd2 expression has been detected during normal aging.

Author(s): 
Wu, Chia-Yu
Chen, Yi-Fan
Wang, Chih-Hao
Kao, Cheng-Heng
Zhuang, Hui-Wen
Chen, Chih-Cheng
Chen, Liang-Kung
Kirby, Ralph
Wei, Yau-Huei
Tsai, Shih-Feng
Tsai, Ting-Fen
Publication Title: 
Science Translational Medicine

Massage therapy is commonly used during physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. Although there is evidence that massage may relieve pain in injured muscle, how massage affects cellular function remains unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of 11 young male participants after exercise-induced muscle damage.

Author(s): 
Crane, Justin D.
Ogborn, Daniel I.
Cupido, Colleen
Melov, Simon
Hubbard, Alan
Bourgeois, Jacqueline M.
Tarnopolsky, Mark A.
Publication Title: 
Circulation Research

RATIONALE: Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. However, the exact mechanism(s) underlying CR-induced cardioprotection remain(s) unknown. Recent evidence indicates that Sirtuins, NAD(+)-dependent deacetylases, regulate various favorable aspects of the CR response. Thus, we hypothesized that deacetylation of specific mitochondrial proteins during CR preserves mitochondrial function and attenuates production of reactive oxygen species during ischemia/reperfusion.

Author(s): 
Shinmura, Ken
Tamaki, Kayoko
Sano, Motoaki
Nakashima-Kamimura, Naomi
Wolf, Alexander M.
Amo, Taku
Ohta, Shigeo
Katsumata, Yoshinori
Fukuda, Keiichi
Ishiwata, Kyoko
Suematsu, Makoto
Adachi, Takeshi
Publication Title: 
PloS One

Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc. However, the molecular targets involved with these mechanisms were not identified. In this study, we attempted to exam the interactome of Huperzine A using a cDNA phage display library and also mammalian brain tissue extracts.

Author(s): 
Guo, Wei
Liu, Shupeng
Peng, Jinliang
Wei, Xiaohui
Sun, Ye
Qiu, Yangsheng
Gao, Guangwei
Wang, Peng
Xu, Yuhong
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