Nanomedicine

Publication Title: 
International Journal of Nanomedicine

Platinum nanoparticle (Pt-np) species are superoxide dismutase/catalase mimetics and also have an activity similar to that of mitochondrial electron transport complex I. To examine if this complex I-like activity functions in vivo, we studied the effects of Pt-nps on the lifespan of a mitochondrial complex I-deficient Caenorhabditis elegans mutant, nuo-1 (LB25) compared with wild-type N2. We synthesized a fusion protein of a cell-penetrating peptide, human immunodeficiency virus-1 TAT (48-60), C-terminally linked to a peptide with a high affinity to platinum (GRKKRRQRRRPPQ-DRTSTWR).

Author(s): 
Sakaue, Yuri
Kim, Juewon
Miyamoto, Yusei
Publication Title: 
International Journal of Nanomedicine

We developed a novel method to prepare nanocapsules. A solute often crystallizes when its solubility alters from one solvent to another, and its firstborn crystals are used as templates to prepare nanocapsules for the first time, which is called firstborn microcrystallization method. By using this method, the maximum diameter of the nanocapsules including artesunate is about 76 nm, and wrapping state is well.

Author(s): 
Xiao, Xin-Cai
Hong, Zong-Guo
Publication Title: 
Therapeutic Delivery

The Institute of Holistic Medical Sciences (IHMS), Kottayam, Kerala, India, the Institute of Macromolecular Science and Engineering (IMSE), Kottayam, Kerala, India and Mathew Ayurveda und Venen Klinik (MUVK), Klagenfurt, Austria, have jointly conducted a 3-day world conference on nanomedicine and drug delivery (WCN 2010) in Kottayam, Kerala, India from 16-18 April 2010. Nanomedicine is defined as the application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials at the nanometer scale.

Author(s): 
Elias, Eldho
Thomas, Sabu
George, Anne
Sebastian, Mathew
Publication Title: 
Therapeutic Delivery

The Institute of Holistic Medical Sciences (IHMS, Kottayam, Kerala, India); the Institute of Macromolecular Science and Engineering (IMSE, Kottayam, Kerala, India) and Mathew Ayurveda und Venen Klinik (MUVK, Klegenfurt, Austria) have jointly conducted a 3-day world conference on Nanomedicine and Drug Delivery (WCN 2011) in Kottayam, Kerala, India from 11-13 March 2011. Application of nanotechnology for treatment, diagnosis, monitoring and control of biological systems has been referred to as 'nanomedicine' by the NIH.

Author(s): 
Ninan, Neethu
Thomas, Sabu
George, Anne
Sebastian, Mathew
Publication Title: 
Advances in Experimental Medicine and Biology

In this paper, we present an overview of Ayurvedic Bhasmas as nanomedicine of herbo-metallic and mineral origin with particular attention to their structural aspects. We find, the Bhasmas as nanomedicines may offer a huge potential for designing new drugs employing the concept of nanotechnology. Thus, the standardization of fabrication process of these formulations is a crucial issue to be addressed. The structure and effectiveness of the Bhasmas as drugs depend largely on their processing history.

Author(s): 
Adhikari, Rameshwar
Publication Title: 
Frontiers in Bioscience (Scholar Edition)

This paper presents an evidence-based model for the nature and mode of action of homeopathic remedies. Recent studies reveal that homeopathic remedies contain nanoparticles (NPs) of source materials formed by "top-down" mechanical grinding in lactose and/or succussion (forceful agitation) in ethanolic solutions. Silica nanostructures formed during succussions in glass and/or biosynthesized by specific plant extract tinctures also may acquire and convey epitaxial information from remedy source materials into higher potencies.

Author(s): 
Bell, Iris R.
Schwartz, Gary E.
Publication Title: 
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae

Nanobiological technology is an important research field in nanotechnology and has extensive applications in medicine. Although initiated lately, application of nanobiological technology in medicine is advancing in good pace in China, mainly involves in fields including nano-scale pharmaceutical carrier, nanoscale diagnostic technology, nanobiomaterials, and nano-scale traditional Chinese medicine.

Author(s): 
Zhang, Yang-de
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