Narcotic Antagonists

Publication Title: 
Stroke

BACKGROUND AND PURPOSE: Central poststroke pain is a chronic neuropathic disorder that follows a stroke. Current research on its management is limited, and no review has evaluated all therapies for central poststroke pain. METHODS: We conducted a systematic review of randomized controlled trials to evaluate therapies for central poststroke pain. We identified eligible trials, in any language, by systematic searches of AMED, CENTRAL, CINAHL, DARE, EMBASE, HealthSTAR, MEDLINE, and PsychINFO.

Author(s): 
Mulla, Sohail M.
Wang, Li
Khokhar, Rabia
Izhar, Zain
Agarwal, Arnav
Couban, Rachel
Buckley, D. Norman
Moulin, Dwight E.
Panju, Akbar
Makosso-Kallyth, Sun
Turan, Alparslan
Montori, Victor M.
Sessler, Daniel I.
Thabane, Lehana
Guyatt, Gordon H.
Busse, Jason W.
Publication Title: 
Schmerz (Berlin, Germany)

MATERIALS AND METHODS: To evaluate the evidence for clinically established pharmacological therapies for constipation in palliative care, a systematic literature review was performed in different databases (Cochrane Library, Embase, PubMed, Ovid MEDLINE, CINAHL), textbooks, and publications.

Author(s): 
Bader, S.
Weber, M.
Becker, G.
Publication Title: 
Trends in Neurosciences

Addictions to cocaine or heroin/prescription opioids [short-acting ?-opioid receptor (MOPr) agonists] involve relapsing cycles, with experimentation/escalating use, withdrawal/abstinence, and relapse/re-escalation. ?-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and exhibit plasticity in addictive-like states. KOPr/dynorphin activation is implicated in depression/anxiety, often comorbid with addictions.

Author(s): 
Butelman, Eduardo R.
Yuferov, Vadim
Kreek, Mary Jeanne
Publication Title: 
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre

OBJECTIVE: The present study was undertaken to evaluate the antinociceptive effects of an ayurvedic polyherbal formulation in rats and mice employing the tail immersion test and acetic acid-induced writhing test, respectively.

Author(s): 
Chandrasekar, S. B.
Divakar, Kalyani
Pawar, A. T.
Goli, Divakar
Harisha, R.
Bhanumathy, M.
Sushma, G.
Shivaprasad, H. N.
Publication Title: 
Schmerz (Berlin, Germany)

MATERIALS AND METHODS: To evaluate the evidence for clinically established pharmacological therapies for constipation in palliative care, a systematic literature review was performed in different databases (Cochrane Library, Embase, PubMed, Ovid MEDLINE, CINAHL), textbooks, and publications.

Author(s): 
Bader, S.
Weber, M.
Becker, G.
Publication Title: 
Journal of Addiction Medicine

Previous studies have not examined patterns of pain treatment use among patients seeking office-based buprenorphine-naloxone treatment (BNT) for opioid dependence. OBJECTIVES: To examine, among individuals with pain seeking BNT for opioid dependence, the use of pain treatment modalities, perceived efficacy of prior pain treatment, and interest in pursuing pain treatment while in BNT.

Author(s): 
Barry, Declan T.
Savant, Jonathan D.
Beitel, Mark
Cutter, Christopher J.
Moore, Brent A.
Schottenfeld, Richard S.
Fiellin, David A.
Publication Title: 
Journal of Addiction Medicine

Previous studies have not examined patterns of pain treatment use among patients seeking office-based buprenorphine-naloxone treatment (BNT) for opioid dependence. OBJECTIVES: To examine, among individuals with pain seeking BNT for opioid dependence, the use of pain treatment modalities, perceived efficacy of prior pain treatment, and interest in pursuing pain treatment while in BNT.

Author(s): 
Barry, Declan T.
Savant, Jonathan D.
Beitel, Mark
Cutter, Christopher J.
Moore, Brent A.
Schottenfeld, Richard S.
Fiellin, David A.
Publication Title: 
Pain

Joint manipulation has long been used for pain relief. However, the underlying mechanisms for manipulation-related pain relief remain largely unexplored. The purpose of the current study was to determine which spinal neurotransmitter receptors mediate manipulation-induced antihyperalgesia. Rats were injected with capsaicin (50 microl, 0.2%) into one ankle joint and mechanical withdrawal threshold measured before and after injection. The mechanical withdrawal threshold decreases 2 h after capsaicin injection.

Author(s): 
Skyba, D. A.
Radhakrishnan, R.
Rohlwing, J. J.
Wright, A.
Sluka, K. A.
Publication Title: 
Brain Research

MAP kinase is associated with delta-opioid receptor (DOR) signaling and plays a role in cell survival/death. Since anisomycin may alter MAP kinase activity and affect neuronal survival, we investigated whether anisomycin alters neuronal response to hypoxic stress and DOR inhibition. The experiments were performed in cultured cortical neurons. MAP kinase activities were determined by immunoblotting and neuronal viability was assessed by LDH leakage and live/dead morphological study.

Author(s): 
Hong, Soon-Sun
Qian, Hong
Zhao, Peng
Bazzy-Asaad, Alia
Xia, Ying
Publication Title: 
Pain

In a previous study, we showed that electroacupuncture (EA) applied to the SI-6 point on the contralateral forelimb produces long-lasting and powerful analgesia in pain caused by ankle sprain in a rat model. To investigate the underlying mechanism of EA analgesia, the present study tested the effects of various antagonists on known endogenous analgesic systems in this model. Ankle sprain was induced in anesthetized rats by overextending their right ankle with repeated forceful plantar flexion and inversion of the foot.

Author(s): 
Koo, Sung Tae
Lim, Kyu Sang
Chung, Kyungsoon
Ju, Hyunsu
Chung, Jin Mo

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