Narcotic Antagonists

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Orexin A (OXA, hypocretin/hcrt 1) is a newly discovered potential analgesic substance. However, whether OXA is involved in acupuncture analgesia remains unknown. The present study was designed to investigate the involvement of spinal OXA in electroacupuncture (EA) analgesia. METHODS: A modified rat model of post-laparotomy pain was adopted and evaluated. Von Frey filaments were used to measure mechanical allodynia of the hind paw and abdomen. EA at 2/15 Hz or 2/100 Hz was performed once on the bilateral ST36 and SP6 for 30 min perioperatively.

Feng, Xiao-Ming
Mi, Wen-Li
Xia, Fang
Mao-Ying, Qi-Liang
Jiang, Jian-Wei
Xiao, Sheng
Wang, Zhi-Fu
Wang, Yan-Qing
Wu, Gen-Cheng
Publication Title: 
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

Acupuncture or electroacupuncture (EA) potentially offers a nonpharmacological approach to reduce high blood pressure (BP). However, ~70% of the patients and animal subjects respond to EA, while 30% do not. EA acts, in part, through an opioid mechanism in the rostral ventrolateral medulla (rVLM) to inhibit sympathoexcitatory reflexes induced by gastric distention. CCK-8 opposes the action of opioids during analgesia. Therefore, we hypothesized that CCK-8 in the rVLM antagonizes EA modulation of sympathoexcitatory cardiovascular reflex responses.

Li, Min
Tjen-A-Looi, Stephanie C.
Guo, Zhi-Ling
Longhurst, John C.
Publication Title: 
Journal of Biomedical Science

BACKGROUND: Clinical and experimental evidence demonstrates that sleep and epilepsy reciprocally affect each other. Previous studies indicated that epilepsy alters sleep homeostasis; in contrast, sleep disturbance deteriorates epilepsy. If a therapy possesses both epilepsy suppression and sleep improvement, it would be the priority choice for seizure control. Effects of acupuncture of Feng-Chi (GB20) acupoints on epilepsy suppression and insomnia treatment have been documented in the ancient Chinese literature, Lingshu Jing (Classic of the Miraculous Pivot).

Yi, Pei-Lu
Lu, Chin-Yu
Cheng, Chiung-Hsiang
Tsai, Yi-Fong
Lin, Chung-Tien
Chang, Fang-Chia


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