Narcotics

Publication Title: 
PLoS medicine

BACKGROUND: Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN.

Author(s): 
Hempenstall, Kathleen
Nurmikko, Turo J.
Johnson, Robert W.
A'Hern, Roger P.
Rice, Andrew S. C.
Publication Title: 
PLoS medicine

BACKGROUND: Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN.

Author(s): 
Hempenstall, Kathleen
Nurmikko, Turo J.
Johnson, Robert W.
A'Hern, Roger P.
Rice, Andrew S. C.
Publication Title: 
Forensic Science International

This study aimed to determine the effect of cocaine on the development and growth of immature and adult blowflies, in an attempt to better understand the impacts of such effects on postmortem interval (PMI) estimation. Twice the lethal dose of cocaine was injected into rabbits. The control animals were injected only with saline solution. Experimental and control rabbits were autopsied, and portions of their livers were exposed to newly eclosed larvae of Chrysomya putoria and Chrysomya albiceps. Larvae were weighed individually every 6 h, up 54 h of exposure.

Author(s): 
de Carvalho, Lucila Maria Lopes
Linhares, ArÌcio Xavier
Badan Palhares, Fortunato Antonio
Publication Title: 
Psychiatry

Psychoanalytic theorists concerned with substance abuse suggest that the affect tolerance and affect expression of addicts are impaired due to preverbal influences. However, psychoanalytic contributions have largely been limited to clinical speculations and case study reports. The present study investigated the hypotheses that opiate abusers will demonstrate more impaired affect tolerance and affect expression than cocaine abusers, and that both groups would appear more impaired than a sample of normals.

Author(s): 
Keller, D. S.
Wilson, A.
Publication Title: 
Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

Tolerance represents a dynamic mechanism that can be used to temper various regulatory processes regardless of whether they mediate excitation or inhibition. Tolerance operationally directs state-dependent attenuation of the action of endogenous and exogenous morphine. For example, tolerance ensures that immuno-inhibition induced by morphine does not compromise a requisite functional system over an extended period of time. In the nervous system, tolerance to inhibitory action insures that excitatory tone is resumed.

Author(s): 
Stefano, George B.
Kream, Richard M.
Esch, Tobias
Publication Title: 
Actas Espanolas De Psiquiatria

INTRODUCTION: The objective is to evaluate the presence of Machiavellian intelligence with the MACH-IV Scale in antisocial patients versus community controls. MATERIAL AND METHODS: Categorical diagnosis and dimensional evaluation program according to IPDE were obtained from 26 controls from the community and 40 patients from a methadone program. Both groups were evaluated on cooperation with TCI and on Machiavellian intelligence with MACH-IV.

Author(s): 
MontaÒÈs Rada, F.
de Lucas-Taracena, M. T.
MartÌn RodrÌguez, M. A.
Publication Title: 
The Linacre Quarterly
Author(s): 
Kelly, G.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis
Author(s): 
Ludwig, A. M.
Lyle, W. H.
Publication Title: 
Postgraduate Medicine
Author(s): 
Zelenik, J. S.
Publication Title: 
The American Journal of Clinical Hypnosis

In this study, 16 patients matched with 16 controls were hypnotized prior to angioplasty. The hypnotized patients had a 25% increase in the time the cardiologist was able to keep the balloon inflated compared to the controls. Of the hypnotized patients, 13% required additional narcotic pain medication during the procedure as compared to 44% for the controls.

Author(s): 
Weinstein, E. J.
Au, P. K.

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