National Institute on Aging (U.S.)

Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts for the Long Life Family Study, endophenotypes that represent exceptional survival were identified and heritability estimates were calculated. Principal components (PCs) analysis was carried out using 28 physiologic measurements from five trait domains (cardiovascular, cognition, physical function, pulmonary, and metabolic).

Author(s): 
Matteini, Amy M.
Fallin, M. Daniele
Kammerer, Candace M.
Schupf, Nicole
Yashin, Anatoli I.
Christensen, Kaare
Arbeev, Konstantin G.
Barr, Graham
Mayeux, Richard
Newman, Anne B.
Walston, Jeremy D.
Publication Title: 
Nature

Calorie restriction (CR), a reduction of 10ñ40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported.

Author(s): 
Mattison, Julie A.
Roth, George S.
Beasley, T. Mark
Tilmont, Edward M.
Handy, April M.
Herbert, Richard L.
Longo, Dan L.
Allison, David B.
Young, Jennifer E.
Bryant, Mark
Barnard, Dennis
Ward, Walter F.
Qi, Wenbo
Ingram, Donald K.
de Cabo, Rafael
Publication Title: 
Nature
Author(s): 
Austad, Steven N.
Publication Title: 
Nature

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported.

Author(s): 
Mattison, Julie A.
Roth, George S.
Beasley, T. Mark
Tilmont, Edward M.
Handy, April M.
Herbert, Richard L.
Longo, Dan L.
Allison, David B.
Young, Jennifer E.
Bryant, Mark
Barnard, Dennis
Ward, Walter F.
Qi, Wenbo
Ingram, Donald K.
de Cabo, Rafael
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