Natriuretic Peptide, C-Type

Publication Title: 
Arthritis & Rheumatology (Hoboken, N.J.)

OBJECTIVE: The C-type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. METHODS: We generated transgenic mice that overexpress CNP (B6.SJL-Col2a1-NPPC) in chondrocytes.

Author(s): 
Bükülmez, Hülya
Khan, Fozia
Bartels, Cynthia F.
Murakami, Shunichi
Ortiz-Lopez, Adriana
Sattar, Abdus
Haqqi, Tariq M.
Warman, Matthew L.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Using a novel marker of C-type natriuretic peptide (CNP) synthesis [amino-terminal pro-CNP (NT-proCNP)], we have recently shown that plasma NT-proCNP is strongly correlated with skeletal growth and markers of bone formation and is reversibly reduced by glucocorticoids. The effects on CNP of other catabolic or anabolic factors, known to affect skeletal growth, are unknown.

Author(s): 
Prickett, Timothy C. R.
Barrell, Graham K.
Wellby, Martin
Yandle, Timothy G.
Richards, A. Mark
Espiner, Eric A.
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